Results 41 to 50 of about 11,497 (72)

Arrestin‐independent internalization of the GLP‐1 receptor is facilitated by a GRK, clathrin, and caveolae‐dependent mechanism

The FEBS Journal, Volume 292, Issue 7, Page 1675-1695, April 2025.
The glucagon‐like peptide‐1 (GLP‐1) receptor is regulated by distinct agonist‐induced and constitutive internalization pathways. Upon agonist stimulation, GLP‐1 receptor activates Gs and Gi/o, then recruits G protein–coupled receptor kinase 2/3/5/6 to phosphorylate the intracellular loops and C‐tail of the receptor.
Ee Von Moo, Thor Christian Møller, Frederikke Astrid Sørensen, Asuka Inoue, Hans Bräuner‐Osborne   +4 more
wiley   +1 more source

Upregulation of Mitf by Phenolic Compounds-Rich Cymbopogon schoenanthus Treatment Promotes Melanogenesis in B16 Melanoma Cells and Human Epidermal Melanocytes [PDF]

, 2017
Melanin provides inherent protection against skin cancer by absorbing broad-spectrum radiant energy of UV radiation. Cutaneous malignant melanoma incidence has recently been observed to increase and the frequency is closely associated with the skin color,
Isoda Hiroko, Kume Sayuri, Neffati Mohamed, Villareal Myra O., ブリリアル マイラ, 礒田 博子   +5 more
core   +1 more source

Estrogen synthesized in the central nervous system enhances MC4R expression and reduces food intake

The FEBS Journal, EarlyView.
Estrogen is regulated by the rate‐limiting enzyme aromatase. This study examines how neuroestrogens, estrogen produced in the brain, regulate appetite through the hypothalamus. Using ovariectomized, aromatase knockout, and brain‐specific aromatase‐restored mice, the study found that neuroestrogens suppress appetite by influencing genes like Mc4r.
Takanori Hayashi, Kanako Kumamoto, Tatsuya Kobayashi, Xinfeng Hou, Shizuko Nagao, Nobuhiro Harada, Shinichiro Honda, Yohei Shimono, Eiji Nishio   +8 more
wiley   +1 more source

Activation of melanocortin receptors MC1 and MC5 attenuates retinal damage in experimental diabetic retinopathy [PDF]

, 2016
We hypothesize that melanocortin receptors (MC) could activate tissue protective circuit in a model of streptozotocin- (STZ-) induced diabetic retinopathy (DR) in mice.
D'Amico, M., D'Amico, M., Di Filippo, C., Di Filippo, C., Ferraraccio, F., Ferraraccio, F., Gesualdo, C., Gesualdo, C., Getting, S.J., Getting, S.J., Grieco, P., Grieco, P., Kaneva, M.K., Kaneva, M.K., Maisto, R., Maisto, R., Merlino, F., Merlino, F., Perretti, M., Perretti, M., Rossi, S., Rossi, S., Simonelli, F., Simonelli, F., Surace, E., Surace, E., Testa, F., Testa, F., Trotta, M.C., Trotta, M.C.   +29 more
core   +4 more sources

Correlation study of facial lipid profile differences and skin physiological characteristics in Chinese women aged 19–33 years

International Journal of Cosmetic Science, EarlyView.
The facial SC lipid profiles of young Chinese women in the early aging stage exhibited significant changes with age. The average chain length of diacylglycerol, triacylglycerol and short‐chain ceramides decreases with age, while the cholesteryl ester and ceramide EO subclasses increase. Some ceramides correlate positively with TEWL, skin elasticity and
Yumei Fan, Chunhua Wei, Ning Su, Yanyun Ma, Wei Liu, Peiwen Sun, Shuo Shan   +6 more
wiley   +1 more source

Both MC1 and MC3 Receptors Provide Protection From Cerebral Ischemia-Reperfusion-Induced Neutrophil Recruitment. [PDF]

, 2015
Objective Neutrophil recruitment is a key process in the pathogenesis of stroke, and may provide a valuable therapeutic target. Targeting the melanocortin receptors (MC) has previously shown to inhibit leukocyte recruitment in peripheral inflammation ...
Cooper, D., Cooper, D., Cvek, U., Cvek, U., Durrenberger, P.F., Durrenberger, P.F., Gavins, F.N., Gavins, F.N., Getting, S.J., Getting, S.J., Holloway, P.M., Holloway, P.M., Orr, A.W., Orr, A.W., Perretti, M., Perretti, M., Trutschl, M., Trutschl, M.   +17 more
core   +1 more source

Premature hair graying: a multifaceted phenomenon

International Journal of Dermatology, Volume 64, Issue 5, Page 819-829, May 2025.
Abstract Premature hair graying (PHG) is the early loss of natural hair color, influenced by genetic, biological, and environmental factors. This review discusses the significant psychological impacts of PHG and explores its underlying mechanisms, related health conditions, and available treatments.
Deesha D. Desai, Maria Karim, Ambika Nohria, Carli Needle, Anna Brinks, Caitlin A. Kearney, Amy Ridge, Natasha Mesinkovska, Jerry Shapiro, Kristen I. Lo Sicco   +9 more
wiley   +1 more source

A Patient with Proopiomelanocortin Deficiency: An Increasingly Important Diagnosis to Make [PDF]

, 2017
Proopiomelanocortin (POMC) deficiency is a rare monogenic disorder with early-onset obesity. Investigation of this entity have increased our insight into the important role of the leptin-melanocortin pathway in energy balance. Here, we present a patient
Achermann, JC, Aycan, Z, Buonocore, F, Cetinkaya, S, Erdeve, SS, Guran, T, Keskin, M, Kurnaz, E, Sagsak, E, Suntharalingham, JP   +9 more
core   +2 more sources

Pathogenesis of Melasma Explained

International Journal of Dermatology, EarlyView.
Pathophysiology of melasma. ABSTRACT This review provides an in‐depth analysis of the pathophysiology of melasma and highlights recent studies that elucidate its underlying mechanisms. Given the prevalence of melasma, a thorough understanding of its pathogenesis is critical for the development of effective treatment strategies.
Lara Ali, Firas Al Niaimi
wiley   +1 more source

Mechanism of Mitf inhibition and morphological differentiation effects of hirsein A on B16 melanoma cells revealed by DNA microarray [PDF]

, 2012
BackgroundWe have previously reported that hirsein A inhibits melanogenesis in B16 melanoma cells by downregulating the Mitf gene expression.ObjectiveIn this study, microarray was employed to determine the transcriptional response of B16 cells to hirsein
Han Junkyu, Ikuta Kenjiro, Isoda Hiroko, Villareal Myra O., 礒田 博子, 韓 畯奎   +5 more
core   +1 more source