Results 41 to 50 of about 184,486 (257)

Inhibition of tyrosinase activity and melanine pigmentation by 2-hydroxytyrosol

Acta Pharmaceutica Sinica B, 2014
2-Hydroxytyrosol (2-HT), originally reported as a synthetic compound, was isolated for the first time as a fungal metabolite. 2-HT was found to inhibit mushroom tyrosinase with an IC50 value of 13.0 µmol/L.
Ryuji Uchida, Seiko Ishikawa, Hiroshi Tomoda   +2 more
doaj   +1 more source

Alpha-Melanocyte–Stimulating Hormone Suppresses Oxidative Stress through a p53-Mediated Signaling Pathway in Human Melanocytes

Molecular Cancer Research, 2012
Epidermal melanocytes are skin cells specialized in melanin production. Activation of the melanocortin 1 receptor (MC1R) on melanocytes by α-melanocyte–stimulating hormone (α-MSH) induces synthesis of the brown/black pigment eumelanin that confers ...
A. L. Kadekaro, Juping Chen, Jennifer Yang, Shun-cun Chen, J. Jameson, V. Swope, T. Cheng, M. Kadakia, Z. Abdel‐Malek   +8 more
semanticscholar   +1 more source

Rational Design of Inner Ear Drug Delivery Systems

Advanced Science, EarlyView.
Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu, Zhiyan Xuan, Haoyu Ren, Keng Chen, Hui Zhang, Huan Wang   +5 more
wiley   +1 more source

Evaluation of the efficacy of Q-switched ruby laser combined with tranexamic acid for melasma and its effects on melanin metabolism

Pifu-xingbing zhenliaoxue zazhi, 2022
Objective To observe the efficacy of Q switch ruby laser combined with tranexamic acid for melasma and its effects on melanin metabolism. Methods A total of 60 patients with melasma were divided into three groups: Drug group (oral tranexamic acid 500 mg ...
Hua LI, Yiyu ZHAO, Yating HU, Yong HAO, Hui HAN   +4 more
doaj   +1 more source

Emerging Nanotechnology Strategies for Obesity Therapy

Advanced Science, EarlyView.
Three types of nanomaterials used for obesity treatment are highlighted, including inorganic nanomaterials, organic nanomaterials and biomimetic nanomaterials. A detailed and comprehensive introduction to the recent nanotechnology strategies for obesity management is also provided, including drug delivery, photodynamic therapy, hyperthermia, gas ...
Weili Chang, Zhaoxu Meng, Yuezhu Zhao, Yake Qi, Zhou Li, He Lian   +5 more
wiley   +1 more source

A Novel Theoretical Hypothesis on Comorbidity in the Elderly—The Disease of Sympathetic Overdrive (DSO)

AGING MEDICINE, EarlyView.
A novel hypothesis: The disease of sympathetic overdrive (DSO) as a unifying mechanism for comorbidity in the elderly. ABSTRACT The coexistence of multimorbidity and geriatric syndromes is a big character and role target to manage for the clinic works in older age, but related theories still require innovation and exploration.
Li Jie, Kong Jian, Yu Boxin, Li Hongyang
wiley   +1 more source

Diglycerides of Natural Phenols and Organic Acids for Enhanced Biological Activities

Asian Journal of Organic Chemistry, EarlyView.
Diglycerides of natural organic acids and phenols were synthesized regio‐selectively. Diglycerides are structurally similar to cell membranes and are expected to exhibit cell affinity and permeability. The flexible glycerol linkers allow the diglycerides to exhibit not only the physiological activities of each constituent organic acid but also the ...
Jisu Hong, Seunghyo Han, Huisu Yeo, Chanyoung Boo, Hyein Kim, Eunbi Kim, Boram Lim, Yeon Jeong Jo, Ji‐Seon Hyun, Nam Ho Lee, Sangho Koo   +10 more
wiley   +1 more source

In vivo multiplex quantitative analysis of 3 forms of alpha melanocyte stimulating hormone in pituitary of prolyl endopeptidase deficient mice

Molecular Brain, 2009
Background In vitro reactions are useful to identify putative enzyme substrates, but in vivo validation is required to identify actual enzyme substrates that have biological meaning. To investigate in vivo effects of prolyl endopeptidase (PREP), a serine
Perroud Bertrand, Alvarado Rudy J, Espinal Glenda M, Morado Alex R, Phinney Brett S, Warden Craig H   +5 more
doaj   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Anti–melanogenic properties of FBCC–EP850 derived from Carex pumila Thunb

Asian Pacific Journal of Tropical Biomedicine
Objective: To elucidate the anti-melanogenic potential of Carex pumila Thunb. extract (FBCC-EP850). Methods: A collection of 180 plant extracts was tested for inhibition of mushroom tyrosinase activity using an in vitro assay.
Mirissa Hewage Dumindu Kavinda, Jinkuk Park, Nayeong Kim, Yung Hyun Choi, Gi-Young Kim   +4 more
doaj   +1 more source