Results 81 to 90 of about 188,005 (273)

A novel approach to target skin photodamage: Topical application of salt inducible kinase inhibitors

International Journal of Cosmetic Science, EarlyView.
UV‐induced photodamage leads to increased DNA damage and elevated MMP levels, which degrade collagen and contribute to wrinkle formation. SLT‐001 and SLT‐008, novel cosmetic ingredients that target salt‐inducible kinase, help reverse this effect by enhancing DNA repair, reducing MMP expression and decreasing erythema, thereby mitigating photodamage ...
Inbal Rachmin, Béatrice Le Varlet, Claire Regazzetti, Thierry Passeron, Jinhua Wang, David E. Fisher, Philippe Schaison, Braham Shroot   +7 more
wiley   +1 more source

MSC‐Derived Secretome and Exosomes in Dermatology: Mechanisms, Therapeutic Opportunities, and Scientific Challenges—A Narrative Review

International Journal of Dermatology, EarlyView.
ABSTRACT Mesenchymal stromal cells (MSCs) exert their effects primarily through paracrine signaling via soluble factors and extracellular vesicles (EVs), especially exosomes. These acellular components offer regenerative and immunomodulatory benefits with fewer safety and logistical constraints than cell‐based therapies.
Marcela da Costa Pereira Cestari, Reinaldo Falavigna Tovo, Daniela Franco Bueno   +2 more
wiley   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

Topical application of a melanotropin analogue to vulgar vitiligo dermo-epidermal minigrafts

Brazilian Journal of Medical and Biological Research, 1998
Human subjects with active vulgar vitiligo do not respond well to autologous dermo-epidermal minigrafting. Eighteen subjects were treated with the a-melanocyte-stimulating hormone (a-MSH) synthetic analogue [Nle4, D-Phe7]-a-MSH.
A.M. Schwartzmann-Solon, M.A. Visconti, A.M.L. Castrucci   +2 more
doaj   +1 more source

Genetics of Common Obesity in Children and Adolescents

Annals of the New York Academy of Sciences, EarlyView.
Abstract Childhood obesity is a multifactorial public health problem worldwide. Genetic variation influences the predisposition to develop obesity at early stages of life. Childhood obesity may be classified as syndromic, monogenic, or polygenic depending on the genetic component.
Guadalupe León‐Reyes, Francisco J. López Alavez, Maria Elizabeth Tejero   +2 more
wiley   +1 more source

Antioxidant and anti-melanogenic activities of ultrasonic extract from Stichopus japonicus

Asian Pacific Journal of Tropical Biomedicine, 2020
Objective: To investigate the antioxidant and anti-melanogenesis activities of an ultrasonic extract of red sea cucumber, Stichopus japonicus, collected from Jeju Island.
Yuling Ding, Chanipa Jiratchayamaethasakul, Junseong Kim, Eun-A Kim, Soo-Jin Heo, Seung-Hong Lee   +5 more
doaj   +1 more source

The Genetic Blueprint of Obesity: From Pathogenesis to Novel Therapies

Obesity Reviews, EarlyView.
ABSTRACT Obesity is a chronic metabolic disease characterized by disturbances in energy homeostasis, leading to excessive fat accumulation. The pathogenesis of the disease is shaped by a complex interplay of genetic, epigenetic, biological, psychological, and environmental factors.
Gašper Tonin, Stjepan Eržen, Zala Mlinarič, Dubravka Jurišić Eržen, Simon Horvat, Tanja Kunej, Jasna Klen   +6 more
wiley   +1 more source

Therapeutic Effects of Stimulating the Melanocortin Pathway in Regulating Ocular Inflammation and Cell Death

Biomolecules
Alpha-melanocyte-stimulating hormone (α-MSH) and its binding receptors (the melanocortin receptors) play important roles in maintaining ocular tissue integrity and immune homeostasis.
Shudan Wang, Francesca Kahale, Amirreza Naderi, Pier Luigi Surico, Jia Yin, Thomas Dohlman, Yihe Chen, Reza Dana   +7 more
doaj   +1 more source

Chemiexcitation in Ex Vivo Porcine Skin Model

Pigment Cell &Melanoma Research, Volume 38, Issue 6, November 2025.
Formation of triplet excited carbonyl by direct chemiexcitation in the fibroblasts of the dermis and in the melanocytes and keratinocytes of the epidermis in the porcine skin, followed by excitation energy transfer from triplet excited carbonyl to melanin via radiative and non‐radiative pathways by indirect chemiexcitation.
Pavel Pospíšil, Vendula Paculová, Ankush Prasad, Michal Berecka   +3 more
wiley   +1 more source

Hormonal regulation of colour change in eyes of a cryptic fish

Biology Open, 2015
Colour change of the skin in lower vertebrates such as fish has been a subject of great scientific and public interest. However, colour change also takes place in eyes of fish and while an increasing amount of data indicates its importance in behaviour ...
Helen Nilsson Sköld, Daniel Yngsell, Muhmd Mubashishir, Margareta Wallin   +3 more
doaj   +1 more source