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Ligands for Melanocortin Receptors: Beyond Melanocyte-Stimulating Hormones and Adrenocorticotropin [PDF]
Biomolecules, 2022 The discovery of melanocortins in 1916 has resulted in more than 100 years of research focused on these peptides. Extensive studies have elucidated well-established functions of melanocortins mediated by cell surface receptors, including MSHR (melanocyte-
Xiao-Chen Yuan, Ya-Xiong Tao
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Recent advances in anterior pituitary hormones and metabolic-associated fatty liver disease [PDF]
Frontiers in EndocrinologyThe classical theory of the pituitary–target gland axis suggests that the hormones secreted by the pituitary gland only regulate the synthesis and secretion of target gland hormones, while the target gland hormones act on the tissues of the body to ...
Changqing Liu +7 more
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Frontiers in Endocrinology, 2022 Cystic fibrosis (CF), which is the most common inherited genetically determined disease caused by a mutation in the gene for the CF transmembrane conductance regulator protein. Pulmonary failure is the leading cause of death in this population, while the
Sabina Galiniak +3 more
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Neuroendocrine and Molecular Interactions in Eating Disorders [PDF]
Psikiyatride Güncel Yaklaşımlar, 2014 There are three basic pillars for the development of eating disorders: genetic predisposition, neuro-endocrine-molecular changes in the brain and metabolic response to it.
Selma Bozkurt Zincir
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Endocrine Connections, 2021 Melanocortin-3 receptor (MC3R) is a regulator of energy homeostasis, and interaction of MC3R and melanocortin-2 receptor accessory protein 2 (MRAP2) plays a critical role in MC3R signaling of mammals.
Ren-Lei Ji +6 more
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Acta Cirúrgica Brasileira, 2022 Purpose: The active melanocytes in the skin were affected by hormones and ultraviolet (UV) irradiation. Licorice zinc has a whitening effect, which may have a prominent potential in the treatment of pigmented skin disease.
Jing-yan Wang +6 more
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alpha-Melanocyte stimulating hormone: production and degradation [PDF]
Journal of Molecular Medicine, 2010 Proopiomelanocortin (POMC) is a polypeptide hormone precursor that is expressed in the brain and in peripheral tissues such as in the pituitary gland, immune system, and skin. In the brain, POMC is processed to form several peptides including alpha-melanocyte stimulating hormone (α-MSH). alpha-MSH is expressed in the hypothalamic arcuate nucleus and in
D'Agostino, Giuseppe, Diano, Sabrina
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Keratinocytes regulate the function of melanocytes
Dermatologica Sinica, 2014 Mammalian keratinocytes compose the bulk of the epithelium, undergo keratinization, and form the dead superficial layer of the skin. These superficial keratinized cells are continuously replaced by cells derived from mitotic cells in the lowest layer of ...
Tomohisa Hirobe
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Transgenerational Social Stress, Immune Factors, Hormones, and Social Behavior
Frontiers in Ecology and Evolution, 2016 A social signal transduction theory of depression has been proposed that states that exposure to social adversity alters the immune response and these changes mediate symptoms of depression such as anhedonia and impairments in social behavior.
Christopher Anthony Murgatroyd +5 more
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Rab3a is critical for trapping alpha-MSH granules in the high Ca²⁺-affinity pool by preventing constitutive exocytosis. [PDF]
PLoS ONE, 2013 Rab3a is a small GTPase of the Rab3 subfamily that acts during late stages of Ca²⁺-regulated exocytosis. Previous functional analysis in pituitary melanotrophs described Rab3a as a positive regulator of Ca²⁺-dependent exocytosis.
Simon Sedej +3 more
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