Intrapituitary Regulatory System of Proliferation of Mammotrophs in the Pituitary Gland [PDF]
, 2004 Anterior pituitary cells produce growth factors plus cytokines and their receptors. Although some of these pituitary growth factors and cytokines are known to be involved in the control of cell differentiation, proliferation and hormone production in the
Takahashi, Sumio
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The multiplicity of post-translational modifications in pro-opiomelanocortin-derived peptides
Frontiers in Endocrinology, 2013 The precursor protein, pro-opiomelanocortin (POMC) undergoes extensive post-translational processing in a tissue-specific manner to yield various biologically active peptides involved in diverse cellular functions.
Akikazu eYasuda +2 more
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The role of hypothalamus-pituitary-adrenal (HPA)-like axis in inflammatory pilosebaceous disorders [PDF]
, 2020 Skin is the largest peripheral endocrine organ and functions as a hormone target and endocrine gland. A cutaneous hypothalamus-pituitary-adrenal (HPA)-like axis enables the skin to respond to stress and regulates its steroidogenic activity.
Clark, Ashley K +3 more
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Frontiers in Endocrinology, 2021 Proopiomelanocortin (POMC) deficiency is an extremely rare inherited autosomal recessive disorder characterized by severe obesity, adrenal insufficiency, skin hypopigmentation, and red hair. It is caused by pathogenic variants in the POMC gene that codes
Nadan Gregoric +18 more
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α-MSH analogue attenuates blood pressure elevation in DOCA-salt hypertensive mice. [PDF]
PLoS ONE, 2013 Melanocyte-stimulating hormones, α-, β- and γ-MSH, regulate important physiological functions including energy homeostasis, inflammation and sodium metabolism.
Petteri Rinne +4 more
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Ultraviolet radiation and melanogenesis [PDF]
, 2004 Light radiation is a part of the electromagnetic radiation, and it consists of the ultraviolet (UV) radiation, visible light, and infrared radiation.
Jovanović Dragan L. +3 more
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Hypothalamic POMC or MC4R deficiency impairs counterregulatory responses to hypoglycemia in mice
Molecular Metabolism, 2019 Objective: Life-threatening hypoglycemia is a major limiting factor in the management of diabetes. While it is known that counterregulatory responses to hypoglycemia are impaired in diabetes, molecular mechanisms underlying the reduced responses remain ...
Benjamin P. Tooke +8 more
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D-TRP(8)-γMSH Prevents the Effects of Endotoxin in Rat Skeletal Muscle Cells through TNFα/NF-KB Signalling Pathway. [PDF]
PLoS ONE, 2016 Sepsis induces anorexia and muscle wasting secondary to an increase in muscle proteolysis. Melanocyte stimulating hormones (MSH) is a family of peptides that have potent anti-inflammatory effects.
Ana Belén Gómez-SanMiguel +3 more
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Multiple sclerosis, relapses, and the mechanism of action of adrenocorticotropic hormone (ACTH)
Frontiers in Neurology, 2013 Relapses in multiple sclerosis (MS) are disruptive and frequently disabling for patients, and their treatment is often a challenge to clinicians. Despite progress in the understanding of the pathophysiology of MS and development of new treatments for ...
Amy ePerrin Ross +3 more
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The role of proopiomelanocortin (POMC) neurones in feeding behaviour
Nutrition & Metabolism, 2007 The precursor protein, proopiomelanocortin (POMC), produces many biologically active peptides via a series of enzymatic steps in a tissue-specific manner, yielding the melanocyte-stimulating hormones (MSHs), corticotrophin (ACTH) and β-endorphin.
Millington George WM
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