Results 41 to 50 of about 6,975 (237)

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

PEARL: Protein Eluting Alginate with Recombinant Lactobacilli

Small, EarlyView.
Probiotic lactobacilli meet engineered living materials: This study introduces PEARL (protein eluting alginate with recombinant lactobacilli), an innovative engineered living material combining Lactiplantibacillus plantarum and alginate beads for controlled protein release.
Varun Sai Tadimarri, Marc Blanch‐Asensio, Ketaki Deshpande, Jonas Baumann, Carole Baumann, Rolf Müller, Sara Trujillo, Shrikrishnan Sankaran   +7 more
wiley   +1 more source

Effects of the POMC System on Glucose Homeostasis and Potential Therapeutic Targets for Obesity and Diabetes

Diabetes, Metabolic Syndrome and Obesity, 2022
Dan Yang,1,2 Xintong Hou,1,2 Guimei Yang,1,2 Mengnan Li,1,2 Jian Zhang,1,2 Minmin Han,1,2 Yi Zhang,3 Yunfeng Liu1 1Department of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China; 2First Clinical Medical ...
Yang D, Hou X, Yang G, Li M, Zhang J, Han M, Zhang Y, Liu Y   +7 more
doaj  

Cryomicroneedle Arrays for Biotherapeutics Delivery

Small Science, EarlyView.
CryoMNs for biotherapeutic delivery to treat various diseases. CryoMNs: cryomicroneedles. Biotherapy offers a promising approach for treating a variety of diseases. However, the lack of advanced delivery systems remains a significant barrier to improve the efficacy, safety, and cost‐effectiveness of biotherapeutics.
Chunli Yang, Li Zhang, Angxi Zhou, Siyi Wang, Ya Ren, Maya Xiang, Run Tian, Yang Yu, Rong Li, Maling Gou   +9 more
wiley   +1 more source

Gene transfer to chicks using lentiviral vectors administered via the embryonic chorioallantoic membrane.

PLoS ONE, 2012
The lack of affordable techniques for gene transfer in birds has inhibited the advancement of molecular studies in avian species. Here we demonstrate a new approach for introducing genes into chicken somatic tissues by administration of a lentiviral ...
Gideon Hen, Sara Yosefi, Dmitry Shinder, Adi Or, Sivan Mygdal, Reba Condiotti, Eithan Galun, Amir Bor, Dalit Sela-Donenfeld, Miriam Friedman-Einat   +9 more
doaj   +1 more source

NEVIGRAV Study: A Case–Control Analysis on Changes in Melanocytic Nevi During Pregnancy

The Journal of Dermatology, EarlyView.
ABSTRACT Pregnancy can influence modifications and appearance of melanocytic nevi, but studies report inconsistent findings, often lacking standardized methods and comparison groups. This study evaluates dermoscopic changes in nevi and the development of new melanocytic lesions in pregnant women using full‐body photography and digital dermoscopy ...
Vincenzo Maione, Anna Venturuzzo, Stefano Bighetti, Carola Romanó, Zeno Fratton, Enzo Errichetti, Marina Venturini, Luca Bettolini   +7 more
wiley   +1 more source

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen, Tamás Kovács, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Structure elucidation of a human melanocortin-4 receptor specific orthosteric nanobody agonist

Nature Communications
The melanocortin receptor 4 (MC4R) belongs to the melanocortin receptor family of G-protein coupled receptors and is a key switch in the leptin-melanocortin molecular axis that controls hunger and satiety.
Thomas Fontaine, Andreas Busch, Toon Laeremans, Stéphane De Cesco, Yi-Lynn Liang, Veli-Pekka Jaakola, Zara Sands, Sarah Triest, Simonas Masiulis, Lies Dekeyzer, Noor Samyn, Nicolas Loeys, Lisa Perneel, Melanie Debaere, Murielle Martini, Charlotte Vantieghem, Richa Virmani, Kamila Skieterska, Stephanie Staelens, Rosa Barroco, Maarten Van Roy, Christel Menet   +21 more
doaj   +1 more source

Psychobiology of feeding behaviour

Dialogues in Clinical Neuroscience & Mental Health, 2018
Adequate nutrition is essential for survival and therefore is ensured by a complex brain system regulating the levels of various nutrients in the blood and in the body stores.
George Konstantakopoulos
doaj   +1 more source