Results 51 to 60 of about 6,975 (237)

Dual Role of Natural Killer Cells in Early Pregnancy: Immunopathological Implications and Therapeutic Potential in Recurrent Spontaneous Abortion and Recurrent Implantation Failure

Cell Proliferation, EarlyView.
This article elaborates on the role of NK cells in early pregnancy from multiple perspectives, including molecular mechanisms and therapeutic interventions. It also discusses how NK cell dysfunction contributes to RSA and RIF, aiming to provide insights for future research on NK cell mechanisms and clinical treatment of RSA and RIF.
Defeng Guan, Zhou Chen, Yuhua Zhang, Wenjie Sun, Lifei Li, Xia Huang   +5 more
wiley   +1 more source

The Role of Proopiomelanocortin and α-Melanocyte-Stimulating Hormone in the Metabolic Syndrome in Psychiatric Disorders: A Narrative Mini-Review

Frontiers in Psychiatry, 2019
The metabolic syndrome (MetS) comprises abdominal obesity, preclinical or full diabetes type 2, arterial hypertension, and dyslipidemia and affects a significant proportion of the general population with a remarkably higher prevalence in patients ...
Stefan Raue, Dirk Wedekind, Jens Wiltfang, Jens Wiltfang, Jens Wiltfang, Ulrike Schmidt, Ulrike Schmidt   +6 more
doaj   +1 more source

Establishment and Validation of a C57BL/6J Mouse Model for Melasma

Cell Proliferation, EarlyView.
A melasma‐like mouse model was established in C57BL/6J mice using a combination of UVB irradiation, progesterone administration, and chronic psychological stress. This model replicates key clinical features and biomarker alterations observed in human melasma. Importantly, it is fundamentally distinct from UV‐induced post‐inflammatory hyperpigmentation (
Wenzhu Wang, Xiaojie Sun, Yunyao Liu, Yin Yang, Hedan Yang, Xiaoli Zhang, Xiuzhen Li, Haoxiang Xu, Xu Chen, Tong Lin   +9 more
wiley   +1 more source

Selected hormonal and neurotransmitter mechanisms regulating feed intake in sheep

Animal, 2010
Appetite control is a major issue in normal growth and in suboptimal growth performance settings. A number of hormones, in particular leptin, activate or inhibit orexigenic or anorexigenic neurotransmitters within the arcuate nucleus of the hypothalamus,
J.L. Sartin, J.A. Daniel, B.K. Whitlock, R.R. Wilborn   +3 more
doaj  

Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro

Frontiers in Pharmacology, 2018
It is now well established that GPR139, a G-protein coupled receptor exclusively expressed in the brain and pituitary, is activated by the essential amino acids L-tryptophan (L-Trp) and L-phenylalanine (L-Phe) via Gαq-coupling.
Diane Nepomuceno, Chester Kuei, Curt Dvorak, Timothy Lovenberg, Changlu Liu, Pascal Bonaventure   +5 more
doaj   +1 more source

Correlation study of facial lipid profile differences and skin physiological characteristics in Chinese women aged 19–33 years

International Journal of Cosmetic Science, EarlyView.
The facial SC lipid profiles of young Chinese women in the early aging stage exhibited significant changes with age. The average chain length of diacylglycerol, triacylglycerol and short‐chain ceramides decreases with age, while the cholesteryl ester and ceramide EO subclasses increase. Some ceramides correlate positively with TEWL, skin elasticity and
Yumei Fan, Chunhua Wei, Ning Su, Yanyun Ma, Wei Liu, Peiwen Sun, Shuo Shan   +6 more
wiley   +1 more source

Anti‐melanogenic effects of Medicago sativa seed extracts on melanocytes

International Journal of Cosmetic Science, EarlyView.
Our study demonstrated that two types of alfalfa seed extract: alfalfa ethanol precipitate (AEP) and alfalfa ethanol supernatant (AES) inhibited melanogenesis through the downregulation of tyrosinase expression, following the inactivation of CREB, b‐catenin and ERK signalling pathway in α‐melanocyte‐stimulating hormone (α‐MSH)‐stimulated B16F10 mouse ...
Chae Rin Kim, Jung Woo, Kyu Lim Kim, Minah Choi, Hee Jung Shin, Junoh Kim, Kyung Min Lim, Chang‐Seok Lee   +7 more
wiley   +1 more source

An α-Melanocyte–Stimulating Hormone Analogue in Erythropoietic Protoporphyria

New England Journal of Medicine, 2009
To the Editor: Patients with erythropoietic protoporphyria, a rare inherited disease, accumulate photosensitizing protoporphyrin in the dermis, which results in severe dermal pain and incapacitating phototoxic reactions when the skin is exposed to visible light, primarily blue light (the Soret band, with the strongest absorbance among the porphyrins).1
Harms, J, Lautenschlager, S, Minder, C E, Minder, E I   +3 more
openaire   +4 more sources

A novel approach to target skin photodamage: Topical application of salt inducible kinase inhibitors

International Journal of Cosmetic Science, EarlyView.
UV‐induced photodamage leads to increased DNA damage and elevated MMP levels, which degrade collagen and contribute to wrinkle formation. SLT‐001 and SLT‐008, novel cosmetic ingredients that target salt‐inducible kinase, help reverse this effect by enhancing DNA repair, reducing MMP expression and decreasing erythema, thereby mitigating photodamage ...
Inbal Rachmin, Béatrice Le Varlet, Claire Regazzetti, Thierry Passeron, Jinhua Wang, David E. Fisher, Philippe Schaison, Braham Shroot   +7 more
wiley   +1 more source

MSC‐Derived Secretome and Exosomes in Dermatology: Mechanisms, Therapeutic Opportunities, and Scientific Challenges—A Narrative Review

International Journal of Dermatology, EarlyView.
ABSTRACT Mesenchymal stromal cells (MSCs) exert their effects primarily through paracrine signaling via soluble factors and extracellular vesicles (EVs), especially exosomes. These acellular components offer regenerative and immunomodulatory benefits with fewer safety and logistical constraints than cell‐based therapies.
Marcela da Costa Pereira Cestari, Reinaldo Falavigna Tovo, Daniela Franco Bueno   +2 more
wiley   +1 more source