Results 71 to 80 of about 92,933 (386)
Evidence for variable selective pressures at MC1R [PDF]
, 2000 It is widely assumed that genes that influence variation in skin and hair pigmentation are under selection. To date,the melanocortin 1 receptor (MC1R) is the only gene identified that explains substantial phenotypic variance inhuman pigmentation. Here we
Birch-Machin, Mark A +10 more
core +2 more sources
Liquid Crystalline Networks Hamper the Malignancy of Cancer Cells
Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.Liquid Crystalline Networks are used as scaffolds for the growth of A375 melanoma cells demonstrating to affect their malignancy. Indeed, only by contact, these materials reduces cell proliferation and colony formation capacity, while increasing the number of senescent cells and promoting the mesenchymal to epithelial transition.
Daniele Martella +9 more
wiley +1 more source
circRNA18_46222157_46248185 inhibits melanogenesis by targeting miR-211/ pathway in goat melanocytes [PDF]
Animal BioscienceObjective This study investigated the effects of circRNA18_46222157_46248185 (named circRNA18) on goat melanogenesis, which differs significantly in goat skins isolated from white and brown coat-colored skins.
Kai Yuan Ji +5 more
doaj +1 more source
Plasticity of differentiated cells in wound repair and tumorigenesis, Part II: Skin and intestine [PDF]
, 2018 Recent studies have identified and begun to characterize the roles of regenerative cellular plasticity in many organs. In Part I of our two-part Review, we discussed how cells reprogram following injury to the stomach and pancreas.
Burclaff, Joseph, Mills, Jason C
core +2 more sources
Rational Design of Inner Ear Drug Delivery Systems
Advanced Science, EarlyView.Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu +5 more
wiley +1 more source
Melanoacanthoma of Pinna-Treated with Skin Grafting: A Case Report [PDF]
Journal of Clinical and Diagnostic Research, 2018 Melanoacanthoma is a very rare cutaneous lesion and it is considered to be a benign neoplasm, which is composed of large dendritic melanocytes and epidermal keratinocytes.
Santosh Uttarkar Pandurangarao +2 more
doaj +1 more source
Maintenance of distinct melanocyte populations in the interfollicular epidermis
Pigment Cell & Melanoma Research, 2015 Hair follicles and sweat glands are recognized as reservoirs of melanocyte stem cells (MSCs). Unlike differentiated melanocytes, undifferentiated MSCs do not produce melanin.
James D. Glover +6 more
semanticscholar +1 more source
The Bioengineering of Microspheric Skin Organoids and Their Application in Drug Screening
Advanced Science, EarlyView.A novel method for the preparation of uniform microspheric skin organoids via spinning bioreactors is developed. The organoid consists of a core‐shell structure to mimic the bilayered skin structure with the epidermis on the surface. For efficient drug screening, the organoid is equipped with a luciferase reporter to detect canonical Wnt signaling, and
Jundong Xie +5 more
wiley +1 more source
Plants, 2021 Kadsura coccinea (KC), a beneficial plant for human health, has been used for centuries in China, Thailand, and Korea in folk medicine and food. There is evidence supporting the biological effects of highly bioactive ingredients in KC such as lignans ...
Joong Suk Jeon +8 more
doaj +1 more source
A melanocyte lineage program confers resistance to MAP kinase pathway inhibition
Nature, 2013 Malignant melanomas harbouring point mutations (Val600Glu) in the serine/threonine-protein kinase BRAF (BRAF(V600E)) depend on RAF–MEK–ERK signalling for tumour cell growth. RAF and MEK inhibitors show remarkable clinical efficacy in BRAF(V600E) melanoma;
Cory M. Johannessen +10 more
semanticscholar +1 more source