Results 51 to 60 of about 53,753 (240)

Melanoacanthoma of Pinna-Treated with Skin Grafting: A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2018
Melanoacanthoma is a very rare cutaneous lesion and it is considered to be a benign neoplasm, which is composed of large dendritic melanocytes and epidermal keratinocytes.
Santosh Uttarkar Pandurangarao, Sridurga Janarthanan, Aravind Darga Ramachandra   +2 more
doaj   +1 more source

Single‐Cell Profiling Reveals a Protective WNT5A‐ATF3‐FOSB Signaling Axis in Hair Follicle Stem Cells During Androgenetic Alopecia

Advanced Science, EarlyView.
Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo, Ke Fang, Changjiang Zhao, Jiachao Xiong, Yuan Zhu, Mingyang Lu, He Yan, Zihan Li, Baojin Wu, Hua Jiang, Yufei Li   +10 more
wiley   +1 more source

Melanocyte-keratinocyte cross-talk in vitiligo [PDF]

, 2023
Vitiligo is a common acquired pigmentary disorder that presents as progressive loss of melanocytes from the skin. Epidermal melanocytes and keratinocytes are in close proximity to each other, forming a functional and structural unit where keratinocytes ...
Roopal V. Kundu, Rasha T. A. Abdel-Aziz, I. Caroline Le Poole, Rohan S. Shivde, Harika Echuri, Ahmed Ahmed Touni, Hossam Abdel-Wahab   +6 more
core   +1 more source

Dual‐Targeting Biomimetic Nanozymes Loaded Microneedle Patch Promotes Scarless Wound Healing Through Anti‐Inflammatory and Anti‐Fibrotic Effects

Advanced Science, EarlyView.
This study developed a dual‐targeting biomimetic nanozyme hybrid system (Cu‐CeO2@ABs‐FTP) and integrated it with HAMA hydrogel to fabricate a microneedle patch (CAF@MN). The patch promotes fibroblast‐mediated wound repair, targets macrophages to induce M2 polarization, and targets myofibroblasts to exert anti‐fibrotic effects, thereby enabling rapid ...
Hongyi Zhang, Jinwei Li, Shan Hua, Shengming Wu, Chenlong He, Yuan Zhu, Ming Yin, Han Zhou, Huawei Liu, Chika Hasegawa, Jun Lyu, Keyue Xiao, Hua Jiang, Yilong Wang, Yuxin Qian   +14 more
wiley   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

High correlation between skin color based on CIELAB color space, epidermal melanocyte ratio, and melanocyte melanin content [PDF]

PeerJ, 2018
Background To treat skin color disorders, such as vitiligo or burns, melanocytes are transplanted for tissue regeneration. However, melanocyte distribution in the human body varies with age and location, making it difficult to select the optimal donor ...
Wen-Shyan Huang, Yi-Wen Wang, Kun-Che Hung, Pai-Shan Hsieh, Keng-Yen Fu, Lien-Guo Dai, Nien-Hsien Liou, Kuo-Hsing Ma, Jiang-Chuan Liu, Niann-Tzyy Dai   +9 more
doaj   +2 more sources

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

Melanocyte progenitor cells reside in human subcutaneous adipose tissue.

PLoS ONE, 2021
Based on the assumption that some progenitor cells in an organ might reside in neighboring adipose tissue, we investigated whether melanocyte progenitor cells reside in human subcutaneous adipose tissue.
Yuri Ikeda, Akino Wada, Toshio Hasegawa, Mutsumi Yokota, Masato Koike, Shigaku Ikeda   +5 more
doaj   +1 more source

Nuclear IDH3A Drives Transcriptional Programs in Melanoma via the YBX1–JUN/FOS Axis

Advanced Science, EarlyView.
Genomic amplification drives aberrant nuclear localization of IDH3A in melanoma. Independent of its canonical metabolic activity, nuclear IDH3A cooperates with YBX1 to activate the c‐JUN/c‐FOS transcriptional program, while NONO facilitates its nuclear localization.
Juan Ran, Yanchun Fang, Shengming Ruan, Juling Wang, Songbai Liu, Yuan Mao, Dongsheng Hou, Yanping Wang, Zi Ye, Qiong Li, Daoxiang Zhang   +10 more
wiley   +1 more source

Pigmented intramucosal nevus of gingiva with a special insight on its pathophysiology: Report of a rare entity

Journal of Dr. NTR University of Health Sciences, 2017
Oral melanotic nevi can be characterized as developmental malformations or melanocytic tumors. Nevi are benign in nature originating from proliferating malfunctioning melanoblasts of the neural crest cells either in the epithelium or in connective tissue.
Rithika Bashamalla, Guttikonda V Rao, Surekha Ramulu, Taneeru Sravya   +3 more
doaj   +1 more source