Results 31 to 40 of about 53,753 (240)

Ocular manifestations of vitiligo: a systematic review

BMC Ophthalmology, 2023
Vitiligo is a disorder characterized by loss of epidermal melanocytes, resulting in depigmented macules and patches. While the relationship between ocular pathology and vitiligo has been demonstrated in conditions such as Vogt-Koyanagi-Harada and ...
Tessa LeWitt, Robert Tauscher, Gracious Obiofuma, Jonna Peterson, Ramez Haddadin, Roopal V. Kundu   +5 more
doaj   +1 more source

Type II Opsins in the Eye, the Pineal Complex and the Skin of Xenopus laevis: Using Changes in Skin Pigmentation as a Readout of Visual and Circadian Activity

Frontiers in Neuroanatomy, 2022
The eye, the pineal complex and the skin are important photosensitive organs. The African clawed frog, Xenopus laevis, senses light from the environment and adjusts skin color accordingly.
Gabriel E. Bertolesi, Nilakshi Debnath, Hannan R. Malik, Lawrence L. H. Man, Sarah McFarlane   +4 more
doaj   +1 more source

Melanoma Inhibitory Activity (MIA) Is Able to Induce Vitiligo-Like Depigmentation in an in vivo Mouse Model by Direct Injection in the Tail

Frontiers in Medicine, 2020
In the complex pathogenesis of vitiligo, the exact mechanism of the dermatosis is still to be clarified. We previously demonstrated that a protein called melanoma inhibitory activity (MIA) is present in non-segmental vitiligo skin and seems to cause the ...
Matteo Bordignon, Roberto Luisetto, Maria Luisa Valente, Marny Fedrigo, Chiara Castellani, Annalisa Angelini, Mauro Alaibac   +6 more
doaj   +1 more source

Searching for some Melanocyte Stem Cell Markers [PDF]

Minia Journal of Medical Research, 2020
Vitiligo, a cutaneous pigmentary disorder caused by selective destruction of melanocytes, is characterized by progressive patchy loss of pigmentation from skin.
Sherif Awad, Noha Moftah, Manal Gabril, Sally Lemby   +3 more
doaj   +1 more source

The Asp84GIu variant of the melanocortin 1 receptor (MC1R)is associated with melanoma [PDF]

, 1996
Melanocyte stimulating hormone (MSH) plays an important role in determining the cutaneous response to ultraviolet radiation and may also influence melanoma progression.
Thody, Anthony J., Haldane, Faye, Jackson, Ian J., Jackson, Ian, Thody, Anthony J, Rees, Jonathan, Rees, Jonathan L., Sikkink, Stephen, Healy, Eugene, Carothers, Andrew, Valverde, Paloma   +10 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Melanocyte Mitogens Induce Both Melanocyte Chemokinesis and Chemotaxis [PDF]

, 1995
It is believed that during repigmentation of vitiligo, inactive melanocytes in the outer root sheath of the hair follicle become activated, proliferate, and migrate into the depigmented skin.
Horikawa, Tatsuya, Morelli, Joseph G., Yohn, Joseph J., Zekman, Tamara, Travers, Jeffrey B., Norris, David A.   +5 more
core   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

Recurrent laryngeal neuropathy secondary to nerve compression by melanomas - case report [PDF]

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Recurrent laryngeal neuropathy (RLN) etiology can be acquired, iatrogenic or idiopathic. There are no previous reports of RLN caused by recurrent laryngeal nerve compression by melanomas.
J.M. Alonso, G.S. Rosa, A. Hataka, C.A. Hussni, M.L. Conceição, M.J. Watanabe, C.A. Rodrigues, A.L.G. Alves   +7 more
doaj   +2 more sources