Results 71 to 80 of about 53,753 (240)

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Hypertension in obesity: A focus on individualized pharmacotherapy and the role of body composition, on behalf of the European Society of Hypertension Working Group on Diabetes and Metabolic Risk Factors and Working Group on Lifestyle, Cardiovascular Pharmacotherapy and Adherence

British Journal of Clinical Pharmacology, EarlyView.
Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activation of the renin–angiotensin–aldosterone system, sympathetic nervous system ...
Christina Antza, Andrej Belancic, Jens Jordan, Alberto Esteban, Anna Oliveras, Ryan McNally, Panagiota Anyfanti, Jorie Versmissen, María S. Fernández‐Alfonso, Vasilios Kotsis, Thomas Weber, Alexandre Persu, Reinhold Kreutz   +12 more
wiley   +1 more source

Melanocyte homeostasis in vivo tolerates Rb1 loss in a developmentally independent fashion

, 2010
There has been uncertainty regarding the precise role that the pocket protein Rb1 plays in murine melanocyte\ud homeostasis. It has been reported that the TAT-Cre mediated loss of exon 19 from a floxed Rb1 allele causes\ud melanocyte apoptosis in vivo ...
Kay, GF, Walker, Graeme J., Kay, Graham F., Wayne A. Schroder, Mould, AW, Schroder, WA, Ian D. Tonks, Arne W. Mould, Hayward, NK, Tonks, ID, Graeme J. Walker, Tonks, Ian D., Bosenberg, Marcus, Mould, Arne W., Bosenberg, M, Schroder, Wayne A., Hacker, Elke, Hacker, E, Elke Hacker, Hayward, Nicholas K., Walker, GJ, Marcus Bosenberg, Nicholas K. Hayward, Graham F. Kay   +23 more
core   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Medical treatment of vitiligo: A narrative review

Pigment International
Vitiligo, a chronic skin condition characterized by depigmentation, poses significant therapeutic challenges. Various medical therapies have been explored to address this disorder, aiming to halt its progression and promote repigmentation.
Anuradha Bishnoi, K.B. Meghana, Davinder Parsad   +2 more
doaj   +1 more source

The Influence of Drosophila Spire and Myosin V During Mid‐Oogenesis Is Independent of Their Direct Interaction

Cytoskeleton, EarlyView.
ABSTRACT Cooperativity between cytoskeletal proteins is crucial for spatiotemporal coordination in biological processes, like oogenesis. In mammalian and Drosophila oogenesis, proper assembly and function of actin networks require coordination between actin assembly factors Spire and formins, as well as actin‐associated proteins like myosins and Rab ...
Joseph Y. Ong, Hannah M. Bailey, Emma Carley, Michelle Panzica, Merin Rixen, Neil Billington, Rong Liu, Margot E. Quinlan   +7 more
wiley   +1 more source

6-Isoprenylindole-3-carboxylic Acid with an Anti-Melanogenic Activity from a Marine-Derived Streptomyces sp. APA-053

Marine Drugs
In this study, we report the isolation of the known compound 6-isoprenylindole-3-carboxylic acid (SJ196), a prenylated indole derivative, from a marine Streptomyces sp., APA053, and its potent anti-melanogenic activity. SJ196 showed ABTS and DPPH radical
Minjeong Kim, Eun-Young Lee, Ga-Eun Shin, Jungwook Chin, Hongchan An, Sang-Jip Nam, Kyung-Min Lim   +6 more
doaj   +1 more source

Melanocyte density under different parameter settings.

, 2012
The three mechanisms for guiding melanocyte growth and migration were tested for their ability to establish a uniform melanocyte distribution at 5%, 10%, 25%, and 40% melanocyte densities.
Timothy J. Lavelle (152636), Josef Thingnes (152633), Eivind Hovig (10027), Stig W. Omholt (152641)   +3 more
core   +1 more source

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source

alpha-Melanocyte-stimulating hormone in neurodegenerative processes

, 2006
The fact that inflammatory processes accompany the neuronal cell death in most neurodegenerative disorders, has in recent years inspired to studies on the role of inflammation in the brain and the possibility to prevent or stop the degenerative processes
Åsa Forslin Aronsson (19492966)
core