Results 101 to 110 of about 54,942 (309)

Cutaneous Pigmentary Changes During Setmelanotide Therapy: Dermoscopic and Confocal Findings in Two Patients

JEADV Clinical Practice, EarlyView.
ABSTRACT Setmelanotide is a melanocortin‐4 receptor agonist approved for the treatment of rare forms of genetic obesity. Through off‐target activation of the melanocortin‐1 receptor, it may induce cutaneous pigmentation changes; however, data regarding its effects on melanocytic nevi remain limited.
Martina Cavicchi, Claudia Lasagni, Silvana Ciardo, Francesca Giusti, Albino Eccher, Caterina Longo   +5 more
wiley   +1 more source

Beyond Skin and Eyes: The Medical and Social Burden of Oculocutaneous Albinism in Africa: A Narrative Review

JEADV Clinical Practice, EarlyView.
ABSTRACT Oculocutaneous albinism (OCA) is a genetic disorder found worldwide, but its impact is particularly pronounced in the African continent. This results from both a higher prevalence and the persistent myths and superstitions surrounding the condition in many African communities.
Rebecca Donadoni, Niccolò Capurro, Alessandro Svizzero, Valeria Brazzelli   +3 more
wiley   +1 more source

Establishment of Primary Cell Cultures from Canine Oral Melanomas via Fine-Needle Aspiration: A Novel Tool for Tumorigenesis and Cancer Progression Studies

Animals
Oral melanomas are the most common oral malignancies in dogs and are characterized by an aggressive nature, invasiveness, and poor prognosis. With biological and genetic similarities to human oral melanomas, they serve as a valuable spontaneous ...
Adriana Lo Giudice, Ilaria Porcellato, Martina Pellegrini, Sven Rottenberg, Chang He, Alfredo Dentini, Giulia Moretti, Monica Cagiola, Luca Mechelli, Elisabetta Chiaradia, Chiara Brachelente   +10 more
doaj   +1 more source

Nail Toxicities Associated With Anticancer Therapies in Children

JEADV Clinical Practice, EarlyView.
ABSTRACT Nail toxicities are a frequent yet often underrecognized component of dermatologic adverse events in children receiving anticancer therapies. Both conventional cytotoxic chemotherapy and newer targeted agents can affect the nail matrix, nail bed and periungual tissues, producing a broad spectrum of clinical manifestations that range from ...
Luca Rapparini, Michela Starace
wiley   +1 more source

Bace2 in normal and malignant melanocytes

, 2017
BACE2 is a gene encoding an aspartic protease called beta-site APP cleaving enzyme-2 that has been shown to cleave PMEL and Tmem27 in mice43,40. The bace2 homozygous zebrafish mutant, in which a point mutation leads to a premature stop codon, shows a ...
Zimmer, Milena A.
core   +2 more sources

Murine neonatal melanocytes exhibit a heightened proliferative response to ultraviolet radiation and migrate to the epidermal basal layer

, 2008
Melanocytes respond to UVR not only by producing melanin, but also by proliferating. This is essentially a protective response. We have studied the melanocyte proliferative response after a single UVR exposure to neonatal mice. At 3 days post-UVR in wild-
Walker, Graeme J., Konrad Muller, H., Walker, G J, Walker, G.J., Ravishankar, Sugandha, Ravishankar, S, Graeme J. Walker, Hayward, N. K., Michael G. Kimlin, H. Konrad Muller, Hayward, N K, Hacker, E, Friedrich Beermann, Nicholas K. Hayward, Beermann, Friedrich, Sugandha Ravishankar, Kimlin, Michael G, Muller, Konrad, Beermann, F, Beermann, F., Hacker, E., Kimlin, Michael G., Hacker, Elke, Ravishankar, S., Muller, H.K., Elke Hacker, Hayward, Nicholas K., Muller, H K, Kimlin, M.G.   +28 more
core   +1 more source

Effectiveness and Safety of Setmelanotide in a Patient With a Heterozygous PCSK1 Deficiency

Obesity, EarlyView.
ABSTRACT Setmelanotide, a melanocortin 4 receptor (MC4R) agonist, is a promising pharmacological treatment option for people with rare monogenic obesity conditions affecting the leptin‐melanocortin signaling pathway, including proprotein convertase subtilisin/kexin type 1 (PCSK1) gene mutations.
Ellina Lytvyak, Arshdeep Rattol, Eduardo Grunvald   +2 more
wiley   +1 more source

Melanin Biopolymers in Pharmacology and Medicine—Skin Pigmentation Disorders, Implications for Drug Action, Adverse Effects and Therapy

Pharmaceuticals
Melanins are biopolymeric pigments formed by a multi-step oxidation process of tyrosine in highly specialized cells called melanocytes. Melanin pigments are mainly found in the skin, iris, hair follicles, and inner ear.
Marta Karkoszka, Jakub Rok, Dorota Wrześniok   +2 more
doaj   +1 more source

Adult human epidermal melanocytes for neurodegeneration research

, 2008
NoNeuronal models for Alzheimer's disease research frequently have limitations as a result of their nonhuman origin and/or transformed state. Here we examined the potential of readily accessible neural crest-derived human epidermal melanocytes isolated ...
Carpenter, Elizabeth, Scally, Andy J., Papageorgiou, Nikolaos, Tobin, Desmond J.   +3 more
core   +1 more source

Monogenic and syndromic obesity in children: Clinical recognition, genetics, and precision management

Pediatric Investigation, EarlyView.
Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil, Eugene Feigin, Hussein Zaitoon   +2 more
wiley   +1 more source