Results 1 to 10 of about 713,163 (381)

Uveal melanoma

Nature Reviews Disease Primers, 2020
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. UMs are usually initiated by a mutation in GNAQ or GNA11, unlike cutaneous melanomas, which usually harbour a BRAF or NRAS mutation. The annual incidence in Europe and the USA is ~6 per million population per year.
Jager, M.J., Shields, C.L., Cebulla, C.M., Abdel-Rahman, M.H., Grossniklaus, H.E., Stern, M.H., Carvajal, R.D., Belfort, R.N., Jia, R.B., Shields, J.A., Damato, B.E.   +10 more
openaire   +4 more sources

The effect of COVID-19 emergency in the management of melanoma in Italy

Dermatology Reports, 2021
The COVID-19 pandemic has severely hampered the functioning of any health system, absorbing a considerable amount of resources and with the threat of widespread infection in the health services.
Intergruppo Melanoma Italiano
doaj   +1 more source

XXVI IMI National Congress - 1st virtual edition | 7-9 November 2020

Dermatology Reports, 2021
s from the XXVI IMI National Congress (virtual edition).
Italian Melanoma Intergroup (IMI)
doaj   +1 more source

Cross-platform comparison of immune signatures in immunotherapy-treated patients with advanced melanoma using a rank-based scoring approach

Journal of Translational Medicine, 2023
Background Gene expression profiling is increasingly being utilised as a diagnostic, prognostic and predictive tool for managing cancer patients. Single-sample scoring approach has been developed to alleviate instability of signature scores due to ...
Yizhe Mao, Tuba N. Gide, Nurudeen A. Adegoke, Camelia Quek, Nigel Maher, Alison Potter, Ellis Patrick, Robyn P. M. Saw, John F. Thompson, Andrew J. Spillane, Kerwin F. Shannon, Matteo S. Carlino, Serigne N. Lo, Alexander M. Menzies, Inês Pires da Silva, Georgina V. Long, Richard A. Scolyer, James S. Wilmott   +17 more
doaj   +1 more source

Lag-3 expression and clinical outcomes in metastatic melanoma patients treated with combination anti-lag-3 + anti-PD-1-based immunotherapies

OncoImmunology, 2023
Lymphocyte-activation gene-3 (LAG-3), an immune checkpoint receptor, negatively regulates T-cell function and facilitates immune escape of tumors. Dual inhibition of LAG-3 and programmed cell death receptor-1 (PD-1) significantly improved progression ...
Tuba N. Gide, Elizabeth C. Paver, Zarwa Yaseen, Nigel Maher, Nurudeen Adegoke, Alexander M. Menzies, Ines Pires da Silva, James S. Wilmott, Georgina V. Long, Richard A. Scolyer   +9 more
doaj   +1 more source

Relatlimab and Nivolumab versus Nivolumab in Untreated Advanced Melanoma.

New England Journal of Medicine, 2022
BACKGROUND Lymphocyte-activation gene 3 (LAG-3) and programmed death 1 (PD-1) are distinct inhibitory immune checkpoints that contribute to T-cell exhaustion.
H. Tawbi, D. Schadendorf, E. Lipson, P. Ascierto, L. Matamala, Erika Castillo Gutiérrez, P. Rutkowski, H. Gogas, C. Lao, J.J. De Menezes, S. Dalle, A. Arance, J. Grob, Shivani Srivastava, Mena Abaskharoun, Melissa Hamilton, S. Keidel, K. Simonsen, A.M. Sobiesk, Bin Li, F. Hodi, G. Long   +21 more
semanticscholar   +1 more source

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma.

New England Journal of Medicine, 2015
BACKGROUND Nivolumab (a programmed death 1 [PD-1] checkpoint inhibitor) and ipilimumab (a cytotoxic T-lymphocyte-associated antigen 4 [CTLA-4] checkpoint inhibitor) have been shown to have complementary activity in metastatic melanoma. In this randomized,
J. Larkin, V. Chiarion-Sileni, R. Gonzalez, J. Grob, C. Cowey, C. Lao, D. Schadendorf, R. Dummer, M. Smylie, P. Rutkowski, P. Ferrucci, A. Hill, J. Wagstaff, M. Carlino, J. Haanen, M. Maio, I. Márquez-Rodas, G. McArthur, P. Ascierto, G. Long, M. Callahan, M. Postow, M. Postow, K. Grossmann, M. Sznol, B. Dréno, L. Bastholt, A. Yang, L. Rollin, C. Horak, F. Hodi, J. Wolchok, J. Wolchok   +32 more
semanticscholar   +2 more sources

XXVIII Italian Melanoma Intergroup National Congress - Florence, Italy | 30 September-2 October 2022

Dermatology Reports, 2023
s from the Italian Melanoma Intergroup (IMI) National ...
Italian Melanoma Intergroup (IMI)
doaj   +1 more source

Melanoma

Atención Primaria, 2004
The incidence of malignant melanoma in the UK is still rising despite public health warnings about the risks of excessive sun exposure. This aggressive tumour can metastasize to virtually any organ, even years after resection of the primary lesion and cause a variety of radiological appearances.
Casanova Seuma, J.M., Ribera Pibernat, M.   +1 more
openaire   +4 more sources

Demographic, Clinical, and Pathologic Features of Patients With Cutaneous Melanoma: Final Analysis of the Brazilian Melanoma Group Database

JCO Global Oncology, 2020
PURPOSE National epidemiologic data on melanoma are scarce in Brazil. The current work presents final demographic, clinical, and pathologic results from the Brazilian Melanoma Group database to detail how patients with melanoma present at diagnosis ...
Alberto Julius Alves Wainstein, João Pedreira Duprat Neto, Mauro Yoshiaki Enokihara, Eduard René Brechtbühl, Felice Riccardi, Gilles Landman, Andreia Cristina de Melo, Vinicius de Lima Vazquez, Rodrigo Ramella Munhoz, Ivan Dunshee De Abranches Oliveira Santos Filho, Eduardo Bertolli, Ana Paula Drummond-Lage, Bianca Costa Soares de Sá, Luciane Botelho, Jose Higino Steck, Francisco Aparecido Belfort, Marcus Maia, Renato Marchiori Bakos, Elimar Elias Gomes, Rafael Schmerling, Flavio Cavarsan   +20 more
doaj   +1 more source