Results 31 to 40 of about 530,239 (305)
Dermatology ReportsBackground: Although immunotherapy has revolutionized melanoma management, there is an urgent need to find useful biomarkers to follow disease evolution and response to therapy.
Italian Melanoma Intergroup
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Approaches to the study of FKBP51 for development of a novel melanoma biomarker. [PDF]
, 2011 Very recently, we have identified that FKBP51 controls response of melanoma to DNA damaging agents. In particular, we found that FKBP51-silencing activated apoptosis in irradiated melanoma, both in vitro and in vivo. Increased levels of FKBP51 were found
ROMANO, MARIA FIAMMETTA
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31 | Effectiveness and safety of adjuvant combo-targeted and immunotherapy in melanoma patients
Dermatology ReportsBackground: Adjuvant combo-targeted therapy (TT) and immunotherapy (IT) reduced relapse risk (HR=0.50) in fully resected stage III melanoma, without improving overall survival (OS). Real-world data are crucial to assess their effectiveness and safety in
Italian Melanoma Intergroup
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Identificação de biomarcadores terapêuticos em melanoma [PDF]
, 2011 Mestrado em Biomedicina MolecularO melanoma deriva da transformação maligna de melanócitos e é frequentemente encontrado na pele e na região ocular. A identificação de marcadores moleculares que inequivocamente indiquem a agressividade do tumor ou que
Tavares, Sandra Raquel de Oliveira
core +1 more source
Nature CommunicationsThe biological underpinnings of therapeutic resistance to immune checkpoint inhibitors (ICI) in adolescent and young adult (AYA) melanoma patients are incompletely understood.
Xinyu Bai +14 more
doaj +1 more source
Dermatology ReportsIntroduction: Non-V600E/K BRAF mutations have been reported in melanoma, but data on their clinical relevance are conflicting. This study investigated the distribution, prognostic role and functional impact of rare BRAF mutations in melanoma.
Italian Melanoma Intergroup
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Retrospective Analysis of Familial Clustering for Malignant Melanoma [PDF]
, 2003 Background: Malignant Melanoma (MM) is familial in 5-7% of cases. Germline mutations of the CDKN2 and CDK4 genes are involved in the pathogenesis of hereditary MM, but the high frequency of familial clustering suggests other genes involved.
DELFINO, MARIO +8 more
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