Journal of the National Comprehensive Cancer Network, 2012 Melanoma is a relatively common neoplasm which is increasing in incidence. Melanoma appears as a variegated irregular maculopapular lesion usually on the skin, but possibly on mucosae, conjunctiva, orbit, nails and oesophagus. They may be black, brown,
Magri, Stephanie, Pace, Keith
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Canadian Medical Association Journal, 2019 AbstractCurrent recommendations by the United States Preventive Services Task Force do not support screening for skin cancer. Melanoma is unique among cancers because detection is through visual inspection. Development of technologies that aid visual inspection have supported screening strategies in high‐risk populations such as older fair skinned ...
Robert, Micieli, Kucy, Pon
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Combination immunotherapy induces distinct T-cell repertoire responses when administered to patients with different malignancies. [PDF]
, 2020 BackgroundCTLA-4 blockade with ipilimumab is Food and Drug Administration-approved for melanoma as a monotherapy and has been shown to modulate the circulating T-cell repertoire.
Cham, Jason +7 more
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Transplantable melanomas in hamsters and gerbils as models for human melanoma : sensitization in melanoma radiotherapy : from animal models to clinical trials [PDF]
, 2018 The focus of the present review is to investigate the role of melanin in the radioprotection of melanoma and attempts to sensitize tumors to radiation by inhibiting melanogenesis. Early studies showed radical scavenging, oxygen consumption and adsorption
Andrzej Słominski +11 more
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Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules [PDF]
, 2018 Background: Microenvironment cues involved in melanoma progression are largely unknown. Melanoma is highly influenced in its aggressive phenotype by the changes it determinates in its microenvironment, such as pH decrease, in turn influencing cancer cell
A Albini +67 more
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Non melanoma skin cancer pathogenesis overview [PDF]
, 2018 (1)Background: Non-melanoma skin cancer is the most frequently diagnosed cancer in humans. The process of skin carcinogenesis is still not fully understood.
Bottoni Ugo +3 more
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PAX2 regulates ADAM10 expression and mediates anchorage-independent cell growth of melanoma cells [PDF]
, 2011 PAX transcription factors play an important role during development and carcinogenesis. In this study, we investigated PAX2 protein levels in melanocytes and melanoma cells by Western Blot and immunofluorescence analysis and characterized the role of ...
Lee, Sophia Boyoung +11 more
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Biology of advanced uveal melanoma and next steps for clinical therapeutics [PDF]
, 2014 Uveal melanoma is the most common intraocular malignancy although it is a rare subset of all melanomas. Uveal melanoma has distinct biology relative to cutaneous melanoma, with widely divergent patient outcomes.
Bastian, BC +17 more
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Sensing of the melanoma biomarker TROY using silicon nanowire field-effect transistors [PDF]
, 2016 Antibody-functionalized silicon nanowire field-effect transistors have been shown to exhibit excellent analyte detection sensitivity enabling sensing of analyte concentrations at levels not readily accessible by other methods.
Erramilli, Shyamsunder +5 more
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Atención Primaria, 2004 The incidence of malignant melanoma in the UK is still rising despite public health warnings about the risks of excessive sun exposure. This aggressive tumour can metastasize to virtually any organ, even years after resection of the primary lesion and cause a variety of radiological appearances.
Casanova Seuma, J.M. +1 more
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