Results 21 to 30 of about 593,039 (291)

01 | End-of-life care in advanced melanoma and other skin cancers: a retrospective cohort from an italian comprehensive cancer center

Dermatology Reports
Background: Despite improvements in overall survival (OS) with immune-checkpoint inhibitors (ICIs) and targeted therapies, many patients with advanced melanoma or non-melanoma skin cancer (NMSC) still experience disease progression (PD) and remain on ...
Italian Melanoma Intergroup
doaj   +3 more sources

Selective induction of cell death in melanoma cell lines through targeting of Mcl-1 and A1. [PDF]

, 2012
Melanoma is an often fatal form of skin cancer which is remarkably resistant against radio- and chemotherapy. Even new strategies that target RAS/RAF signaling and display unprecedented efficacy are characterized by resistance mechanisms.
Berking, Carola, Senft Daniela, Robert Besch, Carola Berking, Saskia A Graf, Claudia Kammerbauer, Thomas Ruzicka, Graf, Saskia A., Besch, Robert, Graf Saskia A., Senft, Daniela, Berking Carola, Kammerbauer, Claudia, Daniela Senft, Besch Robert, Kammerbauer Claudia, Ruzicka, Thomas, Saskia A. Graf, Ruzicka Thomas   +18 more
core   +2 more sources

Prospects for non-immunological molecular therapeutics in melanoma [PDF]

, 2010
In 2006 there were 60,000 new cases of cutaneous melanoma in the European Union and 13,000 deaths (www.europeancancerleagues.org). Currently available systemic treatment options for metastatic melanoma, including both cytotoxic and immunologic therapies,
Tryfonopoulos, Dimitrios, Eustace, Alexander J., Mahgoub, Thamir, O\u27Donovan, Norma, Crown, John, O'Donovan, Norma   +5 more
core   +2 more sources

Identification of new genes associated with melanoma [PDF]

, 2011
Purpose: Repeated failures in melanoma therapy made clear that the molecular mechanisms leading to melanoma are still poorly understood. Here, we aim to provide a more comprehensive understanding of the transcriptional profiles and signaling pathways ...
Mauerer, Andreas
core   +1 more source

A randomised trial evaluating Bevacizumab as adjuvant therapy following resection of AJCC stage IIB, IIC and III cutaneous melanoma : an update [PDF]

, 2008
At present, there are no standard therapies for the adjuvant treatment of malignant melanoma. Patients with primary tumours with a high-Breslow thickness (stages IIB and IIC) or with resected loco-regional nodal disease (stage III) are at high risk of ...
Middleton, M. (Mark), Corrie, P, Middleton, M, Dunn, J., East, C, Lorigan, P; id_orcid, Hern, A., Biswas, S., Wrigley, J., Lorigan, P., Wrigley, J, Dunn, Janet A., Marshall, A. (Andrea), Corrie, P., East, C., Marshall, A.   +15 more
core   +1 more source

10 | Prognostic value of trans epidermal water loss in the treatment of actinic keratoses. A comparison amongst topical therapies for field cancerization

Dermatology Reports
Background: Actinic keratoses (AKs) are one of the most common premalignant skin conditions in the overall population. AKs are considered early precursors that may occasionally progress to squamous cell carcinoma.
Italian Melanoma Intergroup
doaj   +1 more source

Melanoma-associated adhesion molecule MUC18/MCAM (CD146) and transcriptional regulator Mader in normal human CNS [PDF]

, 1998
The proteins MUC18 and Mader have been identified as markers of tumor progression in melanoma cells, MUC18, also known as MCAM (melanoma cell adhesion molecule) and as CD146 (endothelial antigen), is a cell adhesion molecule belonging to the ...
Müller, Norbert, Johnson, Judith P., Kirsch, Kathrin H., Hampel, Harald, Schwarz, Markus J., Ackenheil, Manfred, Penning, Randolph, Körschenhausen, Dirk   +7 more
core   +1 more source

11 | Challenges in developing a digital pathology consultation network: insights from the MELCAYA experience

Dermatology Reports
Background: The increasing adoption of Whole Slide Image (WSI) technology has created new opportunities for collaboration in diagnostic pathology. This study aims to describe the development, implementation, and challenges of establishing a second ...
Italian Melanoma Intergroup
doaj   +1 more source

16 | Sentinel lymph node biopsy in elderly patients with melanoma: prognostic value and impact on recurrence

Dermatology Reports
Background: The role of sentinel lymph node biopsy (SLNB) in elderly patients affected by cutaneous melanoma (CM) remains debated due to comorbidities, surgical risks and especially given the lower SLN positivity rates.
Italian Melanoma Intergroup
doaj   +1 more source

33 | A single center, real world experience with hedgehog pathway inhibitors in advanced basal cell carcinoma

Dermatology Reports
Background: Cutaneous basal cell carcinoma (cBCC) is the most common non melanocytic skin cancer, with a worldwide increased incidence. Basal cell carcinomas are heterogeneous, ranging from superficial or nodular lesions with a good prognosis to ...
Italian Melanoma Intergroup
doaj   +1 more source