Results 221 to 230 of about 167,841 (267)

Experimental model of human melanoma metastases

1991
Models for spontaneous metastasis of human melanoma have recently been developed in nude mice [1, 2, 3, 4, 5, 6, 7]. These models have helped to define the three major steps within the metastatic cascade: cell attachment to basement membranes, membrane degradation, and cell locomotion [8].
D, Herlyn, K, Adachi, H, Koprowski, M, Herlyn   +3 more
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Hematoporphyrin Phototherapy for Experimental Intraocular Malignant Melanoma

Archives of Ophthalmology, 1983
Administration of a hematoporphyrin derivative (HpD) followed by photoradiation with red light completely or partially destroyed Greene hamster melanoma developed in the anterior chamber of rabbit eyes. Tumor-bearing eyes were divided into two groups.
L H, Liu, C, Ni
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Ganglioside profiles of experimental melanomas and of their melanosomal fractions

Melanoma Research, 1995
We compared ganglioside profiles of animal tumours (B16 and Cloudman S91 murine melanomas, Bomirski Syrian hamster melanoma), which are widely used as models of human melanoma, and of their melanosomal fractions. A ganglioside fraction was extracted and purified and the amount of each component ganglioside was assessed by thin-layer chromatography. GM3
E, Vedralová, J, Borovanský, P, Hach
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Experimental melanoma vaccines.

IDrugs : the investigational drugs journal, 2003
There are several immunological implications for the feasibility of melanoma vaccines. Vaccines such as melanoma cell and cell-lysate preparations, chemically characterized and pure melanoma associated antigens (MAA), anti-idiotypic antibodies mimicking MAA, and vectors encoding the genes of MAA have been tested in early and advanced clinical trials ...
Muthukumaran, Sivanandham, Eugene M, Kim, Marc K, Wallack   +2 more
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Experimental ocular malignant melanoma in Sinclair swine

Current Eye Research, 1986
An animal model of malignant melanoma of the eye was established by transplanting a cell suspension from cutaneous melanomas into the anterior chamber of the eye in Sinclair Farm miniature swine. The frequency of tumor takes in the eye was increased from 8.9% to 22% by treating the animals simultaneously with subconjunctival triamcinolone acetonide. As
R P, Burns, M, Tidwell
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IMMUNOTHERAPY AND EXPERIMENTAL APPROACHES FOR METASTATIC MELANOMA

Hematology/Oncology Clinics of North America, 1998
This article reviews the clinical investigations involving recombinant cytokines (either alone or in combination with adoptive immunotherapy, toxicity reduction agents, or cytotoxic chemotherapy), vaccines, monoclonal antibodies or antibody conjugates, and gene therapy.
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Novel Experimental Approaches to Melanoma Diagnosis and Therapy

The Journal of Dermatology, 1994
AbstractWe have investigated the potential use of immune therapies on the growth of melanoma metastases in a new animal model that more closely approximates the clinical situation. We have found that significant benefits towards decreased metastatic growth and subsequent animal survival can be achieved by treatment of tumor‐bearing mice with melanoma ...
V J, Hearing, D M, Gersten, D, Shrayer, L W, Law   +3 more
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Experimental Chemotherapy of Melanoma

1984
Effective treatment of malignant melanoma represents a challenge for the experimental chemotherapist as well as the clinician. The response rates of disseminated or metastatic human melanoma to chemotherapy (either singly or in combination) are poor and average survival of patients is 6 months or less.
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Positron emission tomography of experimental melanoma with.

Nuclear medicine and biology, 2001
Positron emission tomography (PET) has evolved as a new diagnostic modality in cancer patients. Thioureylenes, such as thiouracil and methimazole, are known to be incorporated into growing melanin and selectively retained in melanotic melanoma. In the present study we used [(76)Br]5-bromo-2-thiouracil as tracer for PET imaging of human and murine ...
U, Mårs, V, Tolmachev, A, Sundin
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Experimental drugs for melanoma

2006
U nekoliko posljednjih desetljeća bilježi se značajni porast incidencije melanoma u cijelome svijetu. Međutim, do danas nije potvrđen oblik liječenja koji bi značajno utjecao na preživljenje bolesnika s melanomom u uznapredovalom stadiju bolesti. Stoga se u brojnim pretkliničkim i kliničkim istraživanjima istražuju lijekovi za melanom koji se temelje ...
Kusić, Zvonko, Šamija, Ivan
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