Results 231 to 240 of about 283,745 (306)

Engineered B7‐H3 Binding in Modular Gp2 Miniproteins

Biotechnology and Bioengineering, EarlyView.
ABSTRACT B7‐H3, an important immune checkpoint modulator of T‐cell function, is a tumor vasculature biomarker and is overexpressed in a variety of cancers. Its expression is associated with tumor growth, metastasis, and poor clinical prognosis, which makes B7‐H3 an appealing target for diagnostics and therapeutics.
Abbigael Harthorn, Hannah K. Windsor, Zachary Schmitz, Nathaniel Cheung, Ebube Agwaramgbo, Benjamin J. Hackel   +5 more
wiley   +1 more source

Thrombomodulin facilitates melanoma progression via FAK- and ezrin-mediated phenotypic plasticity. [PDF]

J Biomed Sci
Kuo CH, Sie RH, Ku YC, Wu CL, Hsu CK, Lai CH, Wu HL.   +6 more
europepmc   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

Harnessing SARS-CoV-2 immunity to promote antitumor responses through intratumoral vaccination and adoptive transfer. [PDF]

Front Immunol
Darwish M, Eyouni M, Khan MY, Alsaggaf R, Alharbi R, Hawbani H, Abdulal RH, Alhabbab R, Azhari AA, Altorki T, Alsayb M, Zahid HM, Taher M, Alkayyal A, Hashem AM, Mahmoud AB.   +15 more
europepmc   +1 more source

Advancing design strategies in smart stimulus‐responsive liposomes for drug release and nanomedicine

BMEMat, EarlyView.
Schematic illustration of stimulus‐responsive liposomes designed for controlled drug release and nanomedicine. The innermost circle represents different liposomal structures, including unilamellar, multilamellar, and multivesicular liposomes. The middle layer illustrates the responsive phospholipid components.
Yuchen Guo, Nan Li, Daiwei Zhang, Jingya Gu, Zhihuan Liao, Zihao Teng, Xiangfu Du, Peter S. Timashev, Shipeng Chen, Shuaidong Huo   +9 more
wiley   +1 more source

Melanoma cell inoculation improves cognitive impairment in the 5xFAD mouse model of Alzheimer's disease. [PDF]

Sci Rep
Bruna-Jara B, More J, Lobos P, Ponce DP, Duran-Aniotz C, Valdés JL, Gleisner MA, Tempio F, Salech F, Pizarro M, SanMartín CD, Cárcamo M, Quest AFG, López M, Salazar-Onfray F, Behrens MI.   +15 more
europepmc   +1 more source

Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma, Songyan Li, Jie Yan, Xuechun Wang, Wen Zhao, Yunxuan Song, Dongdong Liu, Jianwei Jiao, Xiuying Duan, Guiqiang Zhang   +9 more
wiley   +1 more source

Physicochemical Characteristics of Amphipathic Peptides and Their Cytotoxic Effects on Cancer and Normal Cell Lines. [PDF]

Int J Mol Sci
Golonka I, Greber KE, Łapińska Z, Wyrzykowski D, Żamojć K, Sikorska E, Kulbacka J, Sawicki W, Musiał W.   +8 more
europepmc   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Plexin A2 Knockdown Enhances Apoptosis in Chemotherapy Treated Melanoma Cells. [PDF]

Oncol Res
Palkina N, Esimbekova A, Lapkina E, Kutsenko V, Zinchenko I, Dereviankin E, Anisimova E, Savchenko A, Ruksha T.   +8 more
europepmc   +1 more source