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Ganglioside profiles of experimental melanomas and of their melanosomal fractions
Melanoma Research, 1995We compared ganglioside profiles of animal tumours (B16 and Cloudman S91 murine melanomas, Bomirski Syrian hamster melanoma), which are widely used as models of human melanoma, and of their melanosomal fractions. A ganglioside fraction was extracted and purified and the amount of each component ganglioside was assessed by thin-layer chromatography. GM3
E, Vedralová, J, Borovanský, P, Hach
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Experimental melanoma vaccines.
IDrugs : the investigational drugs journal, 2003There are several immunological implications for the feasibility of melanoma vaccines. Vaccines such as melanoma cell and cell-lysate preparations, chemically characterized and pure melanoma associated antigens (MAA), anti-idiotypic antibodies mimicking MAA, and vectors encoding the genes of MAA have been tested in early and advanced clinical trials ...
Muthukumaran, Sivanandham +2 more
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IMMUNOTHERAPY AND EXPERIMENTAL APPROACHES FOR METASTATIC MELANOMA
Hematology/Oncology Clinics of North America, 1998This article reviews the clinical investigations involving recombinant cytokines (either alone or in combination with adoptive immunotherapy, toxicity reduction agents, or cytotoxic chemotherapy), vaccines, monoclonal antibodies or antibody conjugates, and gene therapy.
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Experimental ocular malignant melanoma in Sinclair swine
Current Eye Research, 1986An animal model of malignant melanoma of the eye was established by transplanting a cell suspension from cutaneous melanomas into the anterior chamber of the eye in Sinclair Farm miniature swine. The frequency of tumor takes in the eye was increased from 8.9% to 22% by treating the animals simultaneously with subconjunctival triamcinolone acetonide. As
R P, Burns, M, Tidwell
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Novel Experimental Approaches to Melanoma Diagnosis and Therapy
The Journal of Dermatology, 1994AbstractWe have investigated the potential use of immune therapies on the growth of melanoma metastases in a new animal model that more closely approximates the clinical situation. We have found that significant benefits towards decreased metastatic growth and subsequent animal survival can be achieved by treatment of tumor‐bearing mice with melanoma ...
V J, Hearing +3 more
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Experimental Chemotherapy of Melanoma
1984Effective treatment of malignant melanoma represents a challenge for the experimental chemotherapist as well as the clinician. The response rates of disseminated or metastatic human melanoma to chemotherapy (either singly or in combination) are poor and average survival of patients is 6 months or less.
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Positron emission tomography of experimental melanoma with.
Nuclear medicine and biology, 2001Positron emission tomography (PET) has evolved as a new diagnostic modality in cancer patients. Thioureylenes, such as thiouracil and methimazole, are known to be incorporated into growing melanin and selectively retained in melanotic melanoma. In the present study we used [(76)Br]5-bromo-2-thiouracil as tracer for PET imaging of human and murine ...
U, Mårs, V, Tolmachev, A, Sundin
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Melanoma vaccination: state-of-the-art and experimental approaches
Expert Review of Anticancer Therapy, 2001Vaccination therapy for human malignancies is an ever-evolving technology. Great strides are being made in our understanding of the various components of the immune system and how best to manipulate these components.
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Experimental drugs for melanoma
2006U nekoliko posljednjih desetljeća bilježi se značajni porast incidencije melanoma u cijelome svijetu. Međutim, do danas nije potvrđen oblik liječenja koji bi značajno utjecao na preživljenje bolesnika s melanomom u uznapredovalom stadiju bolesti. Stoga se u brojnim pretkliničkim i kliničkim istraživanjima istražuju lijekovi za melanom koji se temelje ...
Kusić, Zvonko, Šamija, Ivan
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Candida albicans enhances experimental hepatic melanoma metastasis
Clinical & Experimental Metastasis, 2009Candida albicans infections are very frequent in cancer patients, whose immune system is often compromised, but whether this fungal pathogen affects cancer progression is unknown. C. albicans infection involves endogenous production of inflammatory cytokines such as tumour necrosis factor alpha (TNF-alpha) and interleukin-18 (IL-18).
Juan, Rodríguez-Cuesta +6 more
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