Results 251 to 260 of about 283,745 (306)

Melanoma stem cells in experimental melanoma are killed by radioimmunotherapy

Nuclear Medicine and Biology, 2013
In spite of recently approved B-RAF inhibitors and immunomodulating antibodies, metastatic melanoma has poor prognosis and novel treatments are needed. Melanoma stem cells (MSC) have been implicated in the resistance of this tumor to chemotherapy.
Thomas, Jandl, Ekaterina, Revskaya, Zewei, Jiang, Matthew, Harris, Olena, Dorokhova, Dina, Tsukrov, Arturo, Casadevall, Ekaterina, Dadachova   +7 more
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Intrasplenic vaccination against experimental melanoma

International Journal of Oncology, 1996
The immunodominant component of a formalinized extracellular antigen (fECA) vaccine prepared from B16 F10 melanoma cells is the melanoma-associated antigen B700. We now demonstrate that a single prophylactic intrasplenic inoculation of B700 antigen (1-10 mu g) stimulates the production of antibodies which have antiproliferative effects on B16 F10 ...
D, Shrayer, C, Park, N, Kouttab, H, Bogaars, R, McInnis, S, Paul, A, Maizel, V, Hearing, H, Wanebo   +8 more
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Experimental trials of immunotherapy for malignant melanoma

Seminars in Surgical Oncology, 1991
AbstractConventional treatment for metastatic melanoma consists of surgical resection, chemotherapy, and radiation therapy. New approaches toward treatment of this disease include the development of passive and active immunotherapeutic regimens. Malignant melanoma is particularly amendable to immunotherapy since the tumor is relatively immunogenic ...
D, Reintgen, J, Becker, H F, Seigler
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Ascorbate in the treatment of experimental transplanted melanoma

The American Journal of Clinical Nutrition, 1991
Sodium ascorbate supplementation in drinking water inhibited subcutaneous tumor growth, enhanced levodopa methylester (LDME) chemotherapy, and increased survival of B16 melanoma-bearing mice. Antitumor activity was greatest in mice fed diets low in tyrosine and phenylalanine (restricted diet). Ascorbate partially protected against LDME-induced decrease
G G, Meadows, H F, Pierson, R M, Abdallah   +2 more
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Pregnancy and the apoptotic pathway in experimental melanoma

Melanoma Research, 2018
Pregnancy-associated melanoma is defined as melanoma diagnosed during pregnancy or within 1 year of delivery. The association of pregnancy with melanoma is well known, but its underlying molecular mechanisms of association are poorly understood. The aim was to assess the expression of apoptosis-related genes in melanoma tumors during pregnancy in an ...
Anamaria S, Facina, Gil, Facina, Ismael D C, Guerreiro da Silva, Silvana A A, Corrêa, Sandra M, Alexandre, Ângela F, Logullo, Jorge K, Hosomi, Mary U, Nakamura   +7 more
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Alkylating benzamides with melanoma cytotoxicity: experimental chemotherapy in a mouse melanoma model

Melanoma Research, 2006
The in-vivo antineoplastic potential of the alkylating N-(2-dialkylaminoethyl)benzamides BZA1 and BZA2, novel melanoma targeted anticancer drugs, was evaluated in a mouse melanoma model with nude mice bearing subcutaneous SkMel28, B16 or WM266-4. The maximal tolerated dose (MTD) for the intraperitoneal application of both agents was found to be 24 mg ...
Markus, Wolf, Helmut, Eskerski, Ulrike, Bauder-Wüst, Uwe, Haberkorn, Michael, Eisenhut   +4 more
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Experimental Melanoma in Hamsters

1966
Melanotic tumours are ranged among the relatively rare tumours found in laboratory animals. The Harding-Passey and Cloudman melanomas in mice currently constitute “classic tumour stock”. Iglesias in 1960 [9] discovered spontaneous melanoma in A × C rats, later, new instances were described in these animals.
B. Oberman, M. R. Rivière
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Heterotransplantation of Experimental Melanoma

1966
During repeated transplantations of experimental melanoblastoma, modifications were observed as regards the successful takes on different species and strains and their ability to form melanic pigment [4], to metastasize [1] and to form ascitic tumors [3].
O. Costachel, I. Popp, S. Dumitrescu, St. Mironescu, M. Nachtigal   +4 more
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Experimental model of human melanoma metastases

1991
Models for spontaneous metastasis of human melanoma have recently been developed in nude mice [1, 2, 3, 4, 5, 6, 7]. These models have helped to define the three major steps within the metastatic cascade: cell attachment to basement membranes, membrane degradation, and cell locomotion [8].
D, Herlyn, K, Adachi, H, Koprowski, M, Herlyn   +3 more
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Hematoporphyrin Phototherapy for Experimental Intraocular Malignant Melanoma

Archives of Ophthalmology, 1983
Administration of a hematoporphyrin derivative (HpD) followed by photoradiation with red light completely or partially destroyed Greene hamster melanoma developed in the anterior chamber of rabbit eyes. Tumor-bearing eyes were divided into two groups.
L H, Liu, C, Ni
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