Results 31 to 40 of about 552,068 (289)

22 | Surgical radicality and reconstructive techniques in melanoma and non-melanoma skin cancer

Dermatology Reports
Background: This prospective case series evaluated the clinical outcomes of skin micro-fragment therapy in managing the excision of local advanced skin cancer. Recently, skin micro-fragment therapy has emerged as a promising alternative of classical skin
Italian Melanoma Intergroup
doaj   +1 more source

Hyperthermia Enhances Doxorubicin Therapeutic Efficacy against A375 and MNT-1 Melanoma Cells [PDF]

, 2021
Diana Salvador, Verónica Bastos, Helena Oliveira   +2 more
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

18 | Surgical management of pregnancy-associated melanoma: a single institution experience with thirty-three pregnant patients

Dermatology Reports
Background: Pregnancy-associated melanoma (PAM) has been associated with poorer outcomes, although the prognostic role of pregnancy remains controversial. Management of PAM is challenging, as no established guidelines are available.
Italian Melanoma Intergroup
doaj   +1 more source

The Current State of Neoadjuvant Therapy in Resectable Advanced Stage Melanoma [PDF]

, 2023
Omar Bushara, Jerica Tidwell, James R. Wester, John T. Miura   +3 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Demographic, Clinical, and Pathologic Features of Patients With Cutaneous Melanoma: Final Analysis of the Brazilian Melanoma Group Database

JCO Global Oncology, 2020
PURPOSE National epidemiologic data on melanoma are scarce in Brazil. The current work presents final demographic, clinical, and pathologic results from the Brazilian Melanoma Group database to detail how patients with melanoma present at diagnosis ...
Alberto Julius Alves Wainstein, João Pedreira Duprat Neto, Mauro Yoshiaki Enokihara, Eduard René Brechtbühl, Felice Riccardi, Gilles Landman, Andreia Cristina de Melo, Vinicius de Lima Vazquez, Rodrigo Ramella Munhoz, Ivan Dunshee De Abranches Oliveira Santos Filho, Eduardo Bertolli, Ana Paula Drummond-Lage, Bianca Costa Soares de Sá, Luciane Botelho, Jose Higino Steck, Francisco Aparecido Belfort, Marcus Maia, Renato Marchiori Bakos, Elimar Elias Gomes, Rafael Schmerling, Flavio Cavarsan   +20 more
doaj   +1 more source

Role of Rho/MRTF in Aggressive Vemurafenib-Resistant Murine Melanomas and Immune Checkpoint Upregulation [PDF]

, 2023
Bardees M. Foda, Richard R. Neubig
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source