Results 31 to 40 of about 7,378 (211)

Organization of the dorsal lateral geniculate nucleus in the mouse [PDF]

, 2017
The dorsal lateral geniculate nucleus (dLGN) of the thalamus is the principal conduit for visual information from retina to visual cortex. Viewed initially as a simple relay, recent studies in the mouse reveal far greater complexity in the way input from
Guido, William, Kerschensteiner, Daniel
core   +2 more sources

Ythdf2 Ablation Protects Aged Retina From RGC Dendrite Shrinking and Visual Decline. [PDF]

Aging Cell
The m6A reader YTHDF2 regulates retinal degeneration caused by aging, which is mediated by its target mRNAs Hspa12a and Islr2. ABSTRACT Aging‐related retinal degeneration and vision loss have been severely affecting the elderly worldwide. Previously, we showed that the m6A reader YTHDF2 is a negative regulator for dendrite development and protection of
Niu F, Long G, Zhang J, Yu J, Ji SJ.
europepmc   +2 more sources

Light-Evoked Calcium Responses of Isolated Melanopsin-Expressing Retinal Ganglion Cells [PDF]

The Journal of Neuroscience, 2007
A small number (<2%) of mammalian retinal ganglion cells express the photopigment melanopsin and are intrinsically photosensitive (ipRGCs). Light depolarizes ipRGCs and increases intracellular calcium levels ([Ca2+]i) but the signaling cascades underlying these responses have yet to be elucidated.
Hartwick, Andrew T. E., Bramley, Jayne R., Yu, Jianing, Stevens, Kelly T., Allen, Charles N., Baldridge, William H., Sollars, Patricia J., Pickard, Gary E.   +7 more
openaire   +2 more sources

Melanopsin mediates retrograde visual signaling in the retina.

PLoS ONE, 2012
The canonical flow of visual signals proceeds from outer to inner retina (photoreceptors → bipolar cells → ganglion cells). However, melanopsin-expressing ganglion cells are photosensitive and functional sustained light signaling to retinal dopaminergic ...
Dao-Qi Zhang, Michael A Belenky, Patricia J Sollars, Gary E Pickard, Douglas G McMahon   +4 more
doaj   +1 more source

RdgB2 is required for dim-light input into intrinsically photosensitive retinal ganglion cells. [PDF]

, 2015
A subset of retinal ganglion cells is intrinsically photosensitive (ipRGCs) and contributes directly to the pupillary light reflex and circadian photoentrainment under bright-light conditions.
Berson, David M, Elsaesser, Rebecca, Güler, Ali D, Hattar, Samer, Montell, Craig, Rupp, Alan, Sheng, Wenlong, Walker, Marquis T, Weng, Shijun   +8 more
core   +2 more sources

Melanopsin-expressing retinal ganglion cells: implications for human diseases

Vision Research, 2011
In the last decade, there was the seminal discovery of melanopsin-expressing retinal ganglion cells (mRGCs) as a new class of photoreceptors that subserve the photoentrainment of circadian rhythms and other non-image forming functions of the eye. Since then, there has been a growing research interest on these cells, mainly focused on animal models ...
LA MORGIA, CHIARA, Ross Cisneros F. N., Hannibal J., MONTAGNA, PASQUALE, Sadun A. A., CARELLI, VALERIO   +5 more
openaire   +3 more sources

Dendritic and axonal targeting patterns of a genetically-specified class of retinal ganglion cells that participate in image-forming circuits. [PDF]

, 2014
BackgroundThere are numerous functional types of retinal ganglion cells (RGCs), each participating in circuits that encode a specific aspect of the visual scene.
Feldheim, David A, Feller, Marla B, Gonzalez, Cristina, Huberman, Andrew D, Sweeney, Neal T, Triplett, Jason W, Wei, Wei   +6 more
core   +2 more sources

Melanopsin-expressing retinal ganglion cells in aging and disease.

Histology and histopathology, 2019
Melanopsin-expressing retinal ganglion cells (mRGCs) constitute a system in the mammalian retina used for irradiance detection, regulating non-image forming functions, such as photoentrainment of circadian rhythms, control of the pupillary light reflex, masking response, light-regulated melatonin secretion, and modulation of the sleep/wake cycle. There
Esquiva, Gema, Hannibal, Jens
openaire   +4 more sources

Melanopsin, the photopigment of intrinsically photosensitive retinal ganglion cells [PDF]

Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012
AbstractMelanopsin (gene symbol: Opn4) is the G protein‐coupled photopigment that confers photosensitivity upon intrinsically photosensitive retinal ganglion cells (ipRGCs). ipRGCs are the third class of retinal photoreceptor in mammals, complementing the two previously identified classes, the rods and cones.
Ignacio Provencio, Daniel M. Warthen
openaire   +1 more source

Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies

npj Aging and Mechanisms of Disease, 2017
Mammals receive light information through the eyes, which perform two major functions: image forming vision to see objects and non-image forming adaptation of physiology and behavior to light.
Megumi Hatori, Claude Gronfier, Russell N. Van Gelder, Paul S. Bernstein, Josep Carreras, Satchidananda Panda, Frederick Marks, David Sliney, Charles E. Hunt, Tsuyoshi Hirota, Toshiharu Furukawa, Kazuo Tsubota   +11 more
doaj   +1 more source