Results 81 to 90 of about 7,378 (211)

Melanopsin and the Intrinsically Photosensitive Retinal Ganglion Cells: Biophysics to Behavior [PDF]

Neuron, 2019
The mammalian visual system encodes information over a remarkable breadth of spatiotemporal scales and light intensities. This performance originates with its complement of photoreceptors: the classic rods and cones, as well as the intrinsically photosensitive retinal ganglion cells (ipRGCs).
openaire   +2 more sources

Loss of Melanopsin-Expressing Retinal Ganglion Cells in Severely Staged Glaucoma Patients [PDF]

Investigative Opthalmology & Visual Science, 2016
Multiple studies have shown overwhelming evidence supporting the impairment of melanopsin function due to glaucoma. However, few studies have been carried out in humans analyzing the histology of melanopsin-expressing retinal ganglion cells (mRGCs) in retinas with glaucoma.
Obara, Elisabeth Anne, Hannibal, Jens, Heegaard, Steffen, Fahrenkrug, Jan   +3 more
openaire   +3 more sources

Biophysical Variation within the M1 Type of Ganglion Cell Photoreceptor

Cell Reports, 2017
Summary: Intrinsically photosensitive retinal ganglion cells of the M1 type encode environmental irradiance for functions that include circadian and pupillary regulation.
Alan J. Emanuel, Kush Kapur, Michael Tri H. Do   +2 more
doaj   +1 more source

Buried Treasure? Overlooked and Newly Discovered Evolutionary Contributions to Human Brain Diseases

Annals of Neurology, Volume 98, Issue 6, Page 1178-1195, December 2025.
[Color figure can be viewed at www.annalsofneurology.org] Recapitulative schema of different exploratory levels of the evolutionary impact on human neurological diseases. Clinical neuroscience focuses on the mechanisms of brain function, but this approach falls short of insights into how the central nervous system (CNS) evolved, both in health and ...
Nico J. Diederich, Martin Brüne, John S. Allen, Nicole Bender, Emiliano Bruner, Jean‐Pierre Changeux, Corrado Cali, Olga Dolgova, Anne Grünewald, Geneviève Konopka, Peng Jin, Roger Lemon, Gilberto Levy, Pierre Magistretti, Markus J. Rantala, Kathleen S. Rockland, Roger Sullivan, Annie Swanepoel, Toshiki Uchihara, Katrin Amunts, Christopher G. Goetz   +20 more
wiley   +1 more source

Loss of Melanopsin-Expressing Retinal Ganglion Cells in Patients With Diabetic Retinopathy [PDF]

Investigative Opthalmology & Visual Science, 2017
Photo-entrainment of the circadian clock is mediated by melanopsin-expressing retinal ganglion cells (mRGCs) located in the retina. Patients suffering from diabetic retinopathy (DR) show impairment of light regulated circadian activity such as sleep disorders, altered blood pressure, and abnormal melatonin secretion. The aim of this study was to assess
Obara, Elisabeth Anne, Hannibal, Jens, Heegaard, Steffen, Fahrenkrug, Jan   +3 more
openaire   +3 more sources

Can Extra Daytime Light Exposure Improve Well-Being and Sleep? A Pilot Study of Patients With Glaucoma

Frontiers in Neurology, 2021
Glaucoma damages retinal ganglion cells, including intrinsically photosensitive retinal ganglion cells (ipRGCs). These cells modulate various non-visual physiological and psychological functions which are modulated by light. In patients with glaucoma, we
Aki Kawasaki, Morgane Udry, Mohamad El Wardani, Mohamad El Wardani, Mirjam Münch   +4 more
doaj   +1 more source

Testing for Multidimensional Color-Emotion Semantic Space [PDF]

, 2015
A subset of retinal ganglion cells expresses melanopsin, a photo-pigment with absorption spectrum peaking at 480 nm (i.e., blue light). These cells can directly respond to light even without classic photoreceptor rods and cones, and are named ...
Brand, Andreas, Chkonia, Eka, Herzog, Michael H., Iannantuoni, Luisa, Kilz, Karin, Kunchulia, Marina, Mohr, Christine, Roinishvili, Maya, Shaqiri, Albulena, Sierro, Sierro, Willemin, Julie   +10 more
core   +8 more sources

Brain and retina in Alzheimer's disease: Pathological intersections and estimates from imaging

Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract Recent studies have highlighted retinal optical coherence tomography (OCT) imaging as a promising biomarker for the early detection of Alzheimer's disease (AD). This review connects AD brain pathology – particularly amyloid beta (Aβ), tau, and vascular changes – with corresponding retinal changes.
M. Amin Banihashemi, Saffire H. Krance, Patrick Xiang Ji, Morgan Koo, Julie Ottoy, Richard H. Swartz, Peter J. Kertes, Christopher Hudson, Maged Goubran, Sandra E. Black   +9 more
wiley   +1 more source

Melanopsin contributions to irradiance coding in the thalamo-cortical visual system.

PLoS Biology, 2010
Photoreception in the mammalian retina is not restricted to rods and cones but extends to a subset of retinal ganglion cells expressing the photopigment melanopsin (mRGCs).
Timothy M Brown, Carlos Gias, Megumi Hatori, Sheena R Keding, Ma'ayan Semo, Peter J Coffey, John Gigg, Hugh D Piggins, Satchidananda Panda, Robert J Lucas   +9 more
doaj   +1 more source

Robust visual cortex evoked potentials (VEP) in Gnat1 and Gnat2 knockout mice

Frontiers in Cellular Neuroscience, 2022
Intrinsically photosensitive retinal ganglion cells (ipRGCs) express the photopigment melanopsin, imparting to themselves the ability to respond to light in the absence of input from rod or cone photoreceptors.
Michael D. Flood, Hannah L. B. Veloz, Samer Hattar, Joao L. Carvalho-de-Souza, Joao L. Carvalho-de-Souza, Joao L. Carvalho-de-Souza, Joao L. Carvalho-de-Souza   +6 more
doaj   +1 more source