Progress on the development of Class A GPCR‐biased ligands
British Journal of Pharmacology, EarlyView.Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales +20 more
wiley +1 more source
Subchronic Toxicity of Green Algae (Spyrogyra SP.) Ethanolic Extract on Hematologic Parameters [PDF]
, 2016 Green Algae, an organism with active substance such as phytomelatonin, has potential to be developed as Indonesian traditional medicine. As the long term addition of Green Algae ethanol extract (Ekstrak etanol ganggang hijau, EEGH) influences the ...
Devi, A. (Anggita) +5 more
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Melatonin and its relationship to plant hormones
Annals of Botany, 2018 M. B. Arnao, J. Hernández-Ruiz
semanticscholar +1 more source
Suprachiasmatic Lesions Prevent an Antigonadal Effect of Melatonin [PDF]
, 1980 Benjamin Rusak
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Artificial intelligence streamlines scientific discovery of drug–target interactions
British Journal of Pharmacology, EarlyView.Abstract Drug discovery is a complicated process through which new therapeutics are identified to prevent and treat specific diseases. Identification of drug–target interactions (DTIs) stands as a pivotal aspect within the realm of drug discovery and development. The traditional process of drug discovery, especially identification of DTIs, is marked by
Yuxin Yang, Feixiong Cheng
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The Circadian Rhythm of Intestinal Melatonin-Synthesizing Enzymes
Revista Cubana de Investigaciones Biomédicas, 2020 Introduction: Melatonin is a hormone tightly related to circadian synchronization. Blood levels of melatonin oscillate in 24-h cycles in close accordance with the external illumination.
Dulce Andrade-Pavón +3 more
doaj
Radioimmunoassay and immunocytochemical studies on the recovery of pineal innervation and function following unilateral denervation : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in physiology at Massey University [PDF]
, 1993 PLEASE NOTE Page 106 is missing from the original copyThe sympathetic noradrenergic neurons of the superior cervical ganglia provide the major source of innervation to the pineal gland Studies described in this thesis were designed to further ...
Prangley, John Richard
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The Short Term Secretion Pattern of Human Serum Melatonin Indicates Apulsatile Hormone Release* [PDF]
, 1989 I Trinchard-Lugan, Franz Waldhauser
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