Results 1 to 10 of about 29,812 (167)

Protective effects of melatonin receptor agonists on endotoxin-ınduced uveitis in rats [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): Melatonin has an important role in regulating a variety of physiological functions of the body. We investigated the protective effects of Agomelatine (AGO) and Ramelteon (RAME) on Endotoxin-Induced Uveitis (EIU) in rats.Materials and ...
Tugba Nurcan Yuksel, Muhammed Yayla, Duygu Kose, Zekai Halici, Erdinc Bozkurt, Erdem Toktay   +5 more
doaj   +2 more sources

The effect of exogenous melatonin and melatonin receptor agonists on intensive care unit and hospital length of stay: A systematic review and meta-analysis. [PDF]

PLoS ONE
IntroductionMelatonin supplements and melatonin receptor agonists are linked to reduced delirium in the Intensive Care Unit (ICU) which we hypothesised may affect the length of stay (LOS) in ICU or in hospital.
Art Burgess Kelleher, Mark O'Donovan, Deborah O'Doherty, Ros Lavery, Elaine Lehane, Mohamad M Saab   +5 more
doaj   +2 more sources

The ubiquitin-specific protease 8 antagonizes melatonin-induced endocytic degradation of MT1 receptor to promote lung adenocarcinoma growth

Journal of Advanced Research, 2022
Introduction: The human genome encodes two melatonin receptors (MT1 and MT2) that relay melatonin signals to cellular interior. Accumulating evidence has linked melatonin to multiple health benefits, among which its anticancer effects have become well ...
Qianhui Sun, Jinrui Zhang, Xiaoxi Li, Guoheng Yang, Shaoxuan Cheng, Dong Guo, Qingqing Zhang, Feng Sun, Feng Zhao, Dian Yang, Shanshan Wang, Taishu Wang, Shuyan Liu, Lijuan Zou, Yingqiu Zhang, Han Liu   +15 more
doaj   +1 more source

ROR: Nuclear Receptor for Melatonin or Not?

Molecules, 2021
Whether the retinoic acid-related orphan receptor (ROR) is a nuclear receptor of melatonin remains controversial. ROR is inextricably linked to melatonin in terms of its expression, function, and mechanism of action.
Haozhen Ma, Jun Kang, Wenguo Fan, Hongwen He, Fang Huang   +4 more
doaj   +1 more source

Does the melatonin receptor 1B gene polymorphism have a role in postoperative delirium? [PDF]

PLoS ONE, 2018
INTRODUCTION:Patients undergoing cardiac surgery are at high risk for postoperative delirium, which is associated with longer hospital and intensive care lengths of stays, increased morbidity and mortality.
Elizabeth Mahanna-Gabrielli, Todd A Miano, John G Augoustides, Cecilia Kim, Joseph E Bavaria, W Andrew Kofke   +5 more
doaj   +1 more source

Pistacia vera Extract Potentiates the Effect of Melatonin on Human Melatonin MT₁ and MT₂ Receptors with Functional Selectivity

Pharmaceutics, 2023
Melatonin is a tryptophan derivative synthesized in plants and animals. In humans, melatonin acts on melatonin MT1 and MT2 receptors belonging to the G protein-coupled receptor (GPCR) family.
Nedjma Labani, Florence Gbahou, Marc Noblet, Bernard Masri, Olivier Broussaud, Jianfeng Liu, Ralf Jockers   +6 more
doaj   +1 more source

Melatonin suppresses sympathetic vasomotor tone through enhancing GABAA receptor activity in the hypothalamus

Frontiers in Physiology, 2023
Introduction: Melatonin (5-methoxy-N-acetyl-tryptamine) is a circadian hormone synthesized and secreted by the pineal gland. In addition to regulating circadian rhythms of many physiological functions, melatonin is involved in regulating autonomic ...
Qiyao Yu, Qiyao Yu, Qi Guo, Qi Guo, Sheng Jin, Chao Gao, Peiru Zheng, De-Pei Li, Yuming Wu, Yuming Wu   +9 more
doaj   +1 more source

Mammalian Melatonin Agonist Pharmaceuticals Stimulate Rhomboid Proteins in Plants

Biomolecules, 2022
Melatonin is a human neurotransmitter and plant signalling metabolite that perceives and directs plant metabolism. The mechanisms of melatonin action in plants remain undefined.
Lauren A. E. Erland, Christopher R. Dumigan, Jillian A. Forsyth, Liubov Frolova, Adam B. Yasunaga, Winnie Pun, Isaac T. S. Li, Michael K. Deyholos, Susan J. Murch   +8 more
doaj   +1 more source

Melatonin Reverses the Warburg-Type Metabolism and Reduces Mitochondrial Membrane Potential of Ovarian Cancer Cells Independent of MT1 Receptor Activation

Molecules, 2022
Ovarian cancer (OC) is the most lethal gynecologic malignancy, and melatonin has shown various antitumor properties. Herein, we investigated the influence of melatonin therapy on energy metabolism and mitochondrial integrity in SKOV-3 cells and tested ...
Maira Smaniotto Cucielo, Roberta Carvalho Cesário, Henrique Spaulonci Silveira, Letícia Barbosa Gaiotte, Sérgio Alexandre Alcantara dos Santos, Debora Aparecida Pires de Campos Zuccari, Fábio Rodrigues Ferreira Seiva, Russel J. Reiter, Luiz Gustavo de Almeida Chuffa   +8 more
doaj   +1 more source

Melatonin mediates monochromatic light–induced proliferation of T/B lymphocytes in the spleen via the membrane receptor or nuclear receptor

Poultry Science, 2020
Our studies found that melatonin mediates the monochromatic light–induced lymphocyte proliferation in chickens. However, melatonin receptor subtypes contain membrane receptor (Mel1a/Mel1b/Mel1c) and nuclear receptor (Retinoic acid receptor–related orphan
Juanjuan Xiong, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Chen   +4 more
doaj   +1 more source