Results 251 to 260 of about 61,717 (309)

Melatonin and Quercetin Co‐Treatment Attenuates Hepatic Damage in Diabetic Rats by Mitigating Oxidative Stress and Inflammation

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 5, May 2026.
Quercetin and melatonin, alone or combined, effectively protect the liver in diabetic rats. The antioxidants reduce hyperglycemia, oxidative stress, and inflammation, preventing hepatic damage. ABSTRACT Liver complications in diabetes are very common, contributing to a high mortality rate, making it essential to develop strategies to minimize this ...
Érique Ricardo Alves, Jaiurte Gomes Martins da Silva, Ismaela Maria Ferreira de Melo, Laís Caroline da Silva Santos, Marcelle Mariana Sales de França, Clovis Lapa Neto, Vanessa Bischoff Medina, Francisco de Assis Leite Souza, Leucio Duarte Vieira, Álvaro Aguiar Coelho Teixeira, Valéria Wanderley Teixeira   +10 more
wiley   +1 more source

A Distinct Tryptophan Metabolic Phenotype Marks Severe Fatigue in Quiescent Crohn's Disease

JCC Plus, Volume 1, Issue 3, May 2026.
ABSTRACT Background Fatigue is a common and debilitating symptom in inflammatory bowel disease (IBD), but its underlying mechanisms remain unclear. Altered tryptophan metabolism may contribute to fatigue. Tryptophan is metabolized through the kynurenine, serotonin, and indole pathway, involving host and microbial processes. We aimed to explore the link
Paula I. Metselaar, Mees J. van der Hoff, Naomi V. Wieser, Olaf Welting, Antoine Lefèvre, Camille Dupuy, Patrick Emond, Joep P. M. Derikx, Wouter J. de Jonge, Geert R. A. M. D'Haens, Anje A. te Velde, Mark Löwenberg, Mohammed Ghiboub   +12 more
wiley   +1 more source

Molecular Investigations on Angiogenesis and Oxidative Stress in Roe Deer (Capreolus capreolus) Bucks' Testes Throughout the Reproductive Cycle

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 345, Issue 4, Page 351-360, May 2026.
ABSTRACT Animals with seasonal reproductive cycles, as the Roe deer (Capreolus capreolus), have developed mechanisms to synchronize reproduction with the environmental cycle in order to optimize reproductive success through melatonin. Angiogenesis and oxidative stress are key processes in spermatogenesis, contributing to testicular remodeling and ...
Ilaria Troisio, Domenico Ventrella, Bálint Lóránt Hausz, Mattia Cesauri, Niccolò Ian Vannetti, Maria Laura Bacci, Alberto Elmi, Augusta Zannoni   +7 more
wiley   +1 more source

Letter to Editor “Melatonin as a Novel Drug to Improve Cardiac Function and Quality of Life in Heart Failure Patients: A Systematic Review and Meta‐Analysis”

Clinical Cardiology, Volume 49, Issue 5, May 2026.
Neda Roshanravan, Sina Pakkhesal, Faezeh Tarighat, Samad Ghaffari   +3 more
wiley   +1 more source

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Nuclear Melatonin Receptors

Biochemistry (Moscow), 2001
Current opinions on the potential role of orphan nuclear retinoid receptors of the ROR/RZR subfamily in regulatory activities of the pineal gland hormone melatonin are reviewed. The mechanisms of receptor--DNA interactions and known coactivators, tissue peculiarities of the expression of different receptor isoforms, and its regulation are described ...
openaire   +2 more sources

Melatonin receptors revisited

Journal of Neural Transmission, 1988
The pineal gland and its major product melatonin have a key role in conveying the environmental photoperiodic stimuli that impinge upon the mammalian reproductive axis. The brain, especially the medial preoptic and suprachiasmatic areas are thought to be the main sites of melatonin's neuroendocrine activity.
openaire   +2 more sources

Functionality of Melatonin Receptors: Internalization

2022
The main step of classical desensitization of a receptor, by mean of its disappearance from the plasma membrane, is its internalization. This is a key factor in the regulation of agonist-mediated signaling pathways, as it most of the time stops the activation of the receptor. Internalization is thus important to evaluate, as a complementary information
Clémence, Dupré, Céline, Legros, Jean A, Boutin   +2 more
openaire   +2 more sources

Melatonin receptors and ligands

2000
The goal of the article is to provide a clearer understanding of how melatonin and its related analogs interact with melatonin receptors with the hope of developing important tools and agents of significant clinical and scientific importance. The review provides a compilation of the currently published melatonergic ligands and their relative affinities
P A, Witt-Enderby, P K, Li
openaire   +2 more sources

Alternative Ligands at Melatonin Receptors

2022
Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone that possesses a wide range of biological effects. Most of the main recognized effects of this hormone in mammals are due to its interaction with two G protein-coupled receptors, MT1 and MT2. Ligand-binding studies have been based on the use of its radioligand analog, 2[125I]-iodomelatonin, a ...
Legros, Céline, Yous, Said, Boutin, Jean   +2 more
openaire   +2 more sources