Results 261 to 270 of about 61,717 (309)
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Investigational melatonin receptor agonists
Expert Opinion on Investigational Drugs, 2010Melatonin is a major chronobiological regulator involved in circadian phasing, sleep, and numerous other functions including cyto-/neuroprotection, immune modulation, and energy metabolism. The suitability of melatonin as a drug is limited because of its short half-life.
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Expert Opinion on Therapeutic Patents, 1999
The hormone melatonin is released following a circardian rhythm with highest levels during the subjective night. It regulates a variety of physiological and neuroendocrine functions through activation of G-protein-coupled membrane receptors in target tissues.
Dieter Steinhilber, Carsten Carlberg
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The hormone melatonin is released following a circardian rhythm with highest levels during the subjective night. It regulates a variety of physiological and neuroendocrine functions through activation of G-protein-coupled membrane receptors in target tissues.
Dieter Steinhilber, Carsten Carlberg
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Melatonin and Melatonin Receptors in Neuroprotection
2016Melatonin (Mel) is a neurohormone which is synthesized from tryptophan with the activation of beta-adrenergic receptors of the pineal gland [2, 11, 36]. It is chemically known as N-acetyl-5-methoxytryptamine [1]. The main task of this hormone is adjusting the rhythm of the body and protecting the biological clock of the body.
Omur Gulsum Deniz +4 more
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Docking studies for melatonin receptors
Expert Opinion on Drug Discovery, 2017Melatonin is a neurohormone that controls many relevant physiological processes beyond the control of circadian rhythms. Melatonin's actions are carried out by two main types of melatonin receptors; MT1 and MT2. These receptors are important, and not just because of the biological actions of its natural agonist; but also, because melatonin analogues ...
Awad Alkozia, Hanan +3 more
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Annual Review of Pharmacology and Toxicology, 1991
D N, Krause, M L, Dubocovich
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D N, Krause, M L, Dubocovich
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Melatonin receptor structures shed new light on melatonin research
Journal of Pineal Research, 2019AbstractThe tryptophan derivative melatonin is an evolutionary old molecule that is involved in a pleiotropy of physiological functions. In humans, age‐related decline of circulating melatonin levels and/or dysregulation of its circadian synthesis pattern have been associated with several disorders and disease states.
Erika Cecon, Lei Liu, Ralf Jockers
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Melatonin Receptors and Melatonin Inhibition of Duck Salt Gland Secretion
General and Comparative Endocrinology, 1999Most of the NaCl ingested by marine birds is reabsorbed from renal filtrate and excreted by the cephalic salt glands as a hypertonic NaCl secretion (SGS). Ducks have salt glands and their kidney cells have melatonin receptors. Melatonin affects glomerular filtration rate and tubular uptake of sodium (Na(+)) in mammals.
Poon, AMS +3 more
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Zhurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia»
Мелатонин – гормон, продуцируемый в центральной нервной системе (эпифизе) и периферических тканях (аппендиксе, поджелудочной железе, надпочечниках, тимусе, простате, яичниках, плаценте). Его секретируют клетки крови (тромбоциты, лимфоциты и эозинофилы) и эндотелий.
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Мелатонин – гормон, продуцируемый в центральной нервной системе (эпифизе) и периферических тканях (аппендиксе, поджелудочной железе, надпочечниках, тимусе, простате, яичниках, плаценте). Его секретируют клетки крови (тромбоциты, лимфоциты и эозинофилы) и эндотелий.
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