Results 41 to 50 of about 29,812 (167)

Melatonin Transmits Photoperiodic Signals through the MT1 Melatonin Receptor [PDF]

The Journal of Neuroscience, 2009
Melatonin transmits photoperiodic signals that regulate reproduction. Two melatonin receptors (MT1 and MT2) have been cloned in mammals and additional melatonin binding sites suggested, but the receptor that mediates the effects of melatonin on the photoperiodic gonadal response has not yet been identified. We therefore investigated in mice whether and
Shinobu, Yasuo, Takashi, Yoshimura, Shizufumi, Ebihara, Horst-Werner, Korf   +3 more
openaire   +2 more sources

Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions

Scientific Reports, 2017
Understanding the function of orphan G protein-coupled receptors (GPCRs), whose cognate ligand is unknown, is of major importance as GPCRs are privileged drug targets for many diseases. Recent phylogenetic studies classified three orphan receptors, GPR61,
Atsuro Oishi, Angeliki Karamitri, Romain Gerbier, Olivier Lahuna, Raise Ahmad, Ralf Jockers   +5 more
doaj   +1 more source

Melatonin reduces LH, 17 beta-estradiol and induces differential regulation of sex steroid receptors in reproductive tissues during rat ovulation

Reproductive Biology and Endocrinology, 2011
Background Melatonin is associated with direct or indirect actions upon female reproductive function. However, its effects on sex hormones and steroid receptors during ovulation are not clearly defined. This study aimed to verify whether exposure to long-
Pinheiro Patrícia Fernanda F, Fioruci Beatriz A, Mendes Leonardo O, Amorim João PA, Teixeira Giovana R, Fávaro Wagner, Seiva Fábio RF, A Chuffa Luiz Gustavo, Fernandes Ana Angélica H, Franci Janete AA, Delella Flávia K, Martinez Marcelo, Martinez Francisco E   +12 more
doaj   +1 more source

Melatonin receptor 1A gene polymorphism rs13140012 and serum melatonin in atherosclerotic versus non-atherosclerotic Egyptian ESRD patients: pilot study

Heliyon, 2020
Aim: To study the relationship between melatonin levels and Melatonin membrane receptor 1A (MTNR1A) SNP (rs13140012) in end-stage renal disease patients (ESRD) in Alexandria, Egypt on maintenance hemodialysis with or without atherosclerosis.
Aliaa Aly El Aghoury, Eman Tayae Elsayed, Noha Mohamed El Kholy, Mohamed Hesham El Nashar, Tarek M. Salem   +4 more
doaj   +1 more source

The Pineal Gland and Breast Cancer: Serum Levels of Melatonin in Patients with Mammary Tumors and Their Relation to Clinical Characteristics

The International Journal of Biological Markers, 1989
Several studies have suggested that the pineal gland hormone melatonin may influence the growth of breast cancer. The importance of melatonin blood concentrations in the clinical history of human breast cancer, however, has still to be defined.
S. Barni, P. Lissoni, A. Sormani, F. Pelizzoni, F. Brivio, S. Crispino, G. Tancini   +6 more
doaj   +1 more source

Genetic effects of melatonin receptor genes on chicken reproductive traits

Czech Journal of Animal Science, 2013
The melatonin receptors are G protein-coupled receptors (GPCR) that bind melatonin. Three types of melatonin receptors have been cloned. The MTNR1A (or Mel1A or MT1) and MTNR1B (or Mel1B or MT2) receptor subtypes are present in humans and other mammals ...
D.Y. Li, L. Zhang, D.G. Smith, H.L. Xu, Y.P. Liu, X.L. Zhao, Y. Wang, Q. Zhu   +7 more
doaj   +1 more source

Melatonin alleviates oxidative stress damage in mouse testes induced by bisphenol A

Frontiers in Cell and Developmental Biology
We investigated the effect of melatonin on bisphenol A (BPA)-induced oxidative stress damage in testicular tissue and Leydig cells. Mice were gavaged with 50 mg/kg BPA for 30 days, and concurrently, were injected with melatonin (10 mg/kg and 20 mg/kg ...
Qi Qi, Qi Qi, Jiaxin Yang, Shuang Li, Shuang Li, Jingjing Liu, Jingjing Liu, Da Xu, Guoqing Wang, Lei Feng, Xiaoyan Pan   +10 more
doaj   +1 more source

Melatonergic Signaling Sustains Food Allergy Through FcεRI Recycling

Research
The prevalence of food allergies is increasing dramatically and causing serious public health concerns. Notably, melatonin metabolism imbalance in patients with food allergies; however, the role of melatonin in food allergies remains unclear.
Youxia Wang, Xinmei Zhang, Ifen Hung, Chunxue Liu, Wenkai Ren, Liangpeng Ge, Hao Wang   +6 more
doaj   +1 more source

Melatonin attenuates atherosclerotic plaque vulnerability through SIRT6-dependent regulation of vascular smooth muscle cells senescence

Redox Biology
Rupture of vulnerable atherosclerotic plaques is a major cause of acute cardiovascular events. Vascular smooth muscle cell (VSMC) senescence promotes plaque vulnerability by impairing fibrous cap integrity.
Yue Wang, Wenxin Zhao, Leli Zhang, Pengrong Guo, Yi Zou, Zhenbai Qin, Yuan Wang, Xiaofan Wu   +7 more
doaj   +1 more source

Scientific Basis for the Potential Use of Melatonin in Bone Diseases: Osteoporosis and Adolescent Idiopathic Scoliosis

Journal of Osteoporosis, 2010
The objective of this paper was to analyze the data supporting the possible role of melatonin on bone metabolism and its repercussion in the etiology and treatment of bone pathologies such as the osteoporosis and the adolescent idiopathic scoliosis (AIS).
E. J. Sánchez-Barceló, M. D. Mediavilla, D. X. Tan, R. J. Reiter   +3 more
doaj   +1 more source