Results 11 to 20 of about 25,767 (309)

Structural basis of the ligand binding and signaling mechanism of melatonin receptors. [PDF]

Nat Commun, 2022
Wang Q, Lu Q, Guo Q, Teng M, Gong Q, Li X, Du Y, Liu Z, Tao Y.   +8 more
europepmc   +3 more sources

New Insights Into the Evolutionary History of Melatonin Receptors in Vertebrates, With Particular Focus on Teleosts. [PDF]

Front Endocrinol (Lausanne), 2020
Maugars G, Nourizadeh-Lillabadi R, Weltzien FA.   +2 more
europepmc   +2 more sources

The potential anti-cancer effects of melatonin on breast cancer

Exploration of Medicine, 2022
Melatonin is the primary hormone of the pineal gland that is secreted at night. It regulates many physiological functions, including the sleep-wake cycle, gonadal activity, free radical scavenging, immunomodulation, neuro-protection, and cancer ...
Naba Kumar Das, Saptadip Samanta
doaj   +1 more source

Melatonin receptor depletion suppressed hCG-induced testosterone expression in mouse Leydig cells

Cellular & Molecular Biology Letters, 2019
Melatonin receptors MT1 and MT2 (genes officially named MTNR1A and MTNR1B, respectively) play crucial roles in melatonin-mediated regulation of circadian rhythms, the immune system, and control of reproduction in seasonally breeding animals.
Yuan Gao, Xiaochun Wu, Shuqin Zhao, Yujun Zhang, Hailong Ma, Zhen Yang, Wanghao Yang, Chen Zhao, Li Wang, Quanwei Zhang   +9 more
doaj   +1 more source

Vascular Melatonin Receptors

Neurosignals, 1993
High-affinity melatonin receptors are expressed in the tail artery of the rat and arteries forming the circle of Willis of the rat and certain primates. The characteristics of the vascular melatonin receptors seem to be similar to the ones described in the central nervous system.
M, Viswanathan, J T, Laitinen, J M, Saavedra   +2 more
openaire   +2 more sources

Melatonin receptor genes

Annals of Medicine, 1998
Melatonin is produced rhythmically by the pineal gland and the retina with increased synthesis during darkness. Pineal melatonin serves as the 'chemical expression of darkness' conveying information on the ambient light-dark cycle into rhythmic bodily functions.
T, Kokkola, J T, Laitinen
openaire   +2 more sources

Melatonin increases growth properties in human dermal papilla spheroids by activating AKT/GSK3β/β-Catenin signaling pathway [PDF]

PeerJ, 2022
Background Melatonin, a neurohormone, maybe involved in physiological processes, such as antioxidation, anti-inflammation, and hair growth. In the present study, we investigated the effects of melatonin on proliferation and intracellular signaling in DP ...
Sowon Bae, Yoo Gyeong Yoon, Ji Yea Kim, In-Chul Park, Sungkwan An, Jae Ho Lee, Seunghee Bae   +6 more
doaj   +2 more sources

A Review of Melatonin, Its Receptors and Drugs

Eurasian Journal of Medicine, 2019
After a Turkish scientist took Nobel Prize due to his contributions to understand clock genes, melatonin, closely related to these genes, may begin to shine.
Mucahit Emet, Halil Ozcan, Lutfu Ozel, Muhammed Yayla, Zekai Halici, Ahmet Hacimuftuoglu   +5 more
doaj   +1 more source

Characterization of the Mel1c melatoninergic receptor in platypus (Ornithorhynchus anatinus). [PDF]

PLoS ONE, 2018
Melatonin is a neurohormone produced in both animals and plants. It binds at least three G-protein-coupled receptors: MT1 and MT2, and Mel1cGPR. Mammalian GPR50 evolved from the reptilian/avian Mel1c and lost its capacity to bind melatonin in all the ...
Célia Gautier, Sophie-Penelope Guenin, Isabelle Riest-Fery, Tahlia Jade Perry, Céline Legros, Olivier Nosjean, Valerie Simonneaux, Frank Grützner, Jean A Boutin   +8 more
doaj   +1 more source

Carbamate Insecticides Target Human Melatonin Receptors. [PDF]

Chem Res Toxicol, 2017
Popovska-Gorevski M, Dubocovich ML, Rajnarayanan RV.   +2 more
europepmc   +2 more sources