Results 71 to 80 of about 13,623 (189)

Sepsis: the evolution of molecular pathogenesis concepts and clinical management

MedComm, Volume 6, Issue 3, March 2025.
(A) The innate and adaptive immune responses established during long‐term evolution can eliminate most invading microorganisms. (B) Sepsis only occurs when the balance is disrupted and the pathogen force overwhelms the host's defense force. (C) Only when the superposition of external forces (sensitive antimicrobial drugs) and internal forces ...
Zhongxue Feng, Lijun Wang, Jing Yang, Tingting Li, Xuelian Liao, Yan Kang, Fei Xiao, Wei Zhang   +7 more
wiley   +1 more source

Modelling population dynamics and seasonal movement to assess and predict the burden of melioidosis.

PLoS Neglected Tropical Diseases, 2019
BackgroundMelioidosis is an infectious disease that is transmitted mainly through contact with contaminated soil or water, and exhibits marked seasonality in most settings, including Southeast Asia.
Wiriya Mahikul, Lisa J White, Kittiyod Poovorawan, Ngamphol Soonthornworasiri, Pataporn Sukontamarn, Phetsavanh Chanthavilay, Graham F Medley, Wirichada Pan-Ngum   +7 more
doaj   +1 more source

Use of Recombinant Escherichia coli Strains in Immunofluorescence Assays for Melioidosis Diagnosis

Pathogens, 2021
Burkholderia pseudomallei is a Gram-negative bacterium and the causative agent of melioidosis in humans and animals in the tropics. The clinical manifestations of melioidosis are diverse, ranging from localized infections to whole-body sepsis.
Kanoknart Lantong, Jirarat Songsri, Sueptrakool Wisessombat, Wanida Mala, Warinda Prommachote, Wilaiwan Senghoi, Manas Kotepui, Jedsada Kaewrakmuk, Treenate Jiranantasak, Apichai Tuanyok, Wiyada Kwanhian Klangbud   +10 more
doaj   +1 more source

Glibenclamide impairs responses of neutrophils against Burkholderia pseudomallei by reduction of intracellular glutathione. [PDF]

, 2016
The major risk factor for melioidosis, an infectious disease caused by B. pseudomallei, is diabetes mellitus. More than half of diabetic melioidosis patients in Thailand were prescribed glibenclamide.
Ato, Manabu, Bancroft, Gregory J, Kewcharoenwong, Chidchamai, Lertmemongkolchai, Ganjana, Nithichanon, Arnone, Rinchai, Darawan   +5 more
core   +1 more source

Tracing melioidosis back to the source: using whole-genome sequencing to investigate an outbreak originating from a contaminated domestic water supply [PDF]

, 2015
Melioidosis, a disease of public health importance in Southeast Asia and northern Australia, is caused by the Gram-negative soil bacillus Burkholderia pseudomallei.
Currie, Bart J., Kaestli, Mirjam, Keim, Paul, Mayo, Mark, McRobb, Evan, Price, Erin P., Sarovich, Derek S.   +6 more
core   +1 more source

Burkholderia pseudomallei in Colombia: Laboratory Approaches to Enhance Diagnostic Accuracy

International Journal of Microbiology, Volume 2025, Issue 1, 2025.
Background Melioidosis is a challenging disease to diagnose, and diagnostic complications can delay treatment, adversely impacting patient outcomes. Methods Over a period of 1 year, 68 isolates, initially identified as Burkholderia spp. or oxidase‐positive nonfermenting Gram‐negative bacilli (excluding Pseudomonas aeruginosa), were collected from ...
Soraya Morales-Lopez, Yeneiris Villero Wolf, Deyner Lechuga, Luis Caicedo, Yiceth Acosta Triana, Liliana Gomez, Luis Rodrigo Ramirez, Leandro Narvaez, Heidy Pinzon, Kelin Esquea, Rafael Barros, Pedro Martinez Ramos, Adriana Marin, Claudia Marcela Parra, Esha Saini   +14 more
wiley   +1 more source

Whole-genome sequencing of Burkholderia pseudomallei isolates from an unusual melioidosis case identifies a polyclonal infection with the same multilocus sequence type [PDF]

, 2015
Twelve Burkholderia pseudomallei isolates collected over a 32-month period from a patient with chronic melioidosis demonstrated identical multilocus sequence types (STs). However, whole-genome sequencing suggests a polyclonal infection. This study is the
Currie, Bart J., Foster, Jeffrey T., Kaestli, Mirjam, Keim, Paul, Mayo, Mark, Pearson, Talima, Price, Erin P., Sarovich, Derek S., Tuanyok, Apichai, Viberg, Linda   +9 more
core   +1 more source

A Coinfection Model of Leptospirosis and Melioidosis With Optimal Control

Journal of Applied Mathematics, Volume 2025, Issue 1, 2025.
Leptospirosis and melioidosis are emerging tropical diseases that are seriously affecting both human and animal populations worldwide. The actual incidence and fatal cases of the diseases are underreported due to a lack of awareness of the diseases, underuse of clinical microbiology laboratories test, and limitations of the model.
Habtamu Ayalew Engida, David Mwangi Theuri, Duncan Kioi Gathungu, John Gachohi, Haileyesus Tessema Alemneh, Keshlan S. Govinder   +5 more
wiley   +1 more source

Seroprevalence of melioidosis and its association with blood profiles and pathogens in sheltered dogs in southern Thailand [PDF]

Veterinary World
Background and Aim: Melioidosis is a notable zoonotic disease in Thailand that can affect both humans and animals. Although dogs are one of the most popular pets worldwide, there is a remarkable lack of information on the prevalence and knowledge of ...
Punpichaya Fungwithaya, Worakan Boonhoh, Narin Sontigun, Orachun Hayakijkosol, Wiyada Kwanhian Klangbud, Tuempong Wongtawan   +5 more
doaj   +1 more source

Septicemic melioidosis complicating undiagnosed chronic kidney disease and beta-thalassemia minor in a Bangladeshi farmer

Saudi Journal of Kidney Diseases and Transplantation, 2020
Melioidosis is an emerging infectious disease in many countries including Bangladesh. Patients with diabetes mellitus are at increased risk for infection by Burkholderia pseudomallei, the causative agent for melioidosis.
Muhammad Abdur Rahim, Muhammad Abu Yousuf Khan, Tufayel Ahmed Chowdhury, Mehruba Alam Ananna   +3 more
doaj   +1 more source