Functional analysis of the Escherichia coli mrdA gene in melittin resistance [PDF]
Frontiers in MicrobiologyObjectiveThe aim of this study is to examine the functional role and resistance mechanisms of the Escherichia coli (E. coli) peptidoglycan transpeptidase gene, mrdA, in resistance to melittin.MethodsThe resistance of E.
Chong-Yi Zhao +5 more
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Potential Inhibitory Effect of the Peptide Melittin Purified from Apis mellifera Venom on CTX-M-Type Extended-Spectrum β-Lactamases of Escherichia coli [PDF]
AntibioticsBackground. Extended-spectrum β-lactamases (ESBLs) hydrolyze nearly all β-lactam antibiotics, affecting one of the most important groups of antimicrobials used in Gram-negative infections. Among them, CTX-M is the most widespread type of ESBL. This study
Sheril Ramos-Alcántara +3 more
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Synthesis and Evaluation of Melittin-Modified Peptides for Antibacterial Activity [PDF]
ToxinsMelittin, a naturally occurring antimicrobial peptide, demonstrates broad-spectrum activity, effectively suppressing and eliminating both Gram-positive and Gram-negative bacteria, including specific drug-resistant strains.
Xiangxiang Xu +8 more
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Animal Cells and Systems, 2022 Melittin is a major component of bee venom; it is widely used in traditional medicine because of its therapeutic effects, such as anti-inflammatory effects.
Haesoo Jung +5 more
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Melittin suppresses growth and induces apoptosis of non-small-cell lung cancer cells via down-regulation of TGF-β-mediated ERK signal pathway [PDF]
Brazilian Journal of Medical and Biological Research, 2020 The purpose of this study was to investigate the anti-cancer effect of melittin on growth, migration, invasion, and apoptosis of non-small-cell lung cancer (NSCLC) cells.
Renzhi Yu +3 more
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Nanoparticle incorporation of melittin reduces sperm and vaginal epithelium cytotoxicity. [PDF]
PLoS ONE, 2014 Melittin is a cytolytic peptide component of bee venom which rapidly integrates into lipid bilayers and forms pores resulting in osmotic lysis. While the therapeutic utility of free melittin is limited by its cytotoxicity, incorporation of melittin into ...
Andrew P Jallouk +6 more
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Cancer Nanotechnology, 2021 Background Melittin, a peptide component of honey bee venom, is an appealing candidate for cancer therapy. In the current study, melittin, melittin-loaded niosome, and empty niosome had been optimized and the anticancer effect assessed in vitro on 4T1 ...
Farnaz Dabbagh Moghaddam +7 more
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Induction of WNT16 via peptide-mRNA nanoparticle-based delivery maintains cartilage homeostasis [PDF]
, 2020 Osteoarthritis (OA) is a progressive joint disease that causes significant disability and pain and for which there are limited treatment options. We posit that delivery of anabolic factors that protect and maintain cartilage homeostasis will halt or ...
Akk, Antonina +6 more
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Opposite Regulatory Effects of Immobilized Cations on the Folding Vs. Assembly of Melittin
Frontiers in Chemistry, 2021 Ions are crucial in modulating the protein structure. For the free ions in bulk solution, ammonium is kosmotropic (structure forming) and guanidinium is chaotropic (structure breaking) to the protein structure within the Hofmeister series.
Lanlan Yu +7 more
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Delivery of Melittin as a Lytic Agent via Graphene Nanoparticles as Carriers to Breast Cancer Cells
Journal of Functional Biomaterials, 2022 Melittin, as an agent to lyse biological membranes, may be a promising therapeutic agent in the treatment of cancer. However, because of its nonspecific actions, there is a need to use a delivery method.
Karolina Daniluk +5 more
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