Results 11 to 20 of about 7,897 (182)
FcIgG-GE11-Melittin as a novel EGFR targeted peptibody with potent cytotoxic activity against cancer cells [PDF]
Scientific ReportsThe overexpression of epidermal growth factor receptor (EGFR) in various cancer types makes it an attractive target for therapeutic intervention. In this study, we designed a novel peptibody, FcIgG-GE11-Melittin, by fusing Melittin, a cytotoxic peptide ...
Malihe Hallaji +5 more
doaj +2 more sources
The current landscape of the antimicrobial peptide melittin and its therapeutic potential
Frontiers in ImmunologyMelittin, a main component of bee venom, is a cationic amphiphilic peptide with a linear α-helix structure. It has been reported that melittin can exert pharmacological effects, such as antitumor, antiviral and anti-inflammatory effects in vitro and in ...
Na Xu, Liu Wensen
exaly +3 more sources
Antimicrobial peptides from arthropod venoms exhibit activity against Sporothrix species [PDF]
Journal of Venomous Animals and Toxins including Tropical DiseasesBackground: Sporotrichosis is a fungal infection caused by species of the Sporothrix schenckii complex. Antifungal treatment with itraconazole and amphotericin B is limited by increasing resistance, adverse effects, and prolonged treatment courses ...
Maiara Campolina de Miranda +7 more
doaj +3 more sources
Functional reprogramming of melittin by Pluronic® F-127 enables anticancer selectivity with attenuated hemolytic activity [PDF]
Frontiers in OncologyIntroductionConventional anticancer treatments have a number of limitations, including significant toxicity to healthy cells. Therefore, it is necessary to explore new therapeutic methods and strategies that utilize bioactive compounds with high ...
Grzegorz Król +9 more
doaj +2 more sources
Animal Cells and Systems, 2022 Melittin is a major component of bee venom; it is widely used in traditional medicine because of its therapeutic effects, such as anti-inflammatory effects.
Haesoo Jung +5 more
doaj +1 more source
Melittin suppresses growth and induces apoptosis of non-small-cell lung cancer cells via down-regulation of TGF-β-mediated ERK signal pathway [PDF]
Brazilian Journal of Medical and Biological Research, 2020 The purpose of this study was to investigate the anti-cancer effect of melittin on growth, migration, invasion, and apoptosis of non-small-cell lung cancer (NSCLC) cells.
Renzhi Yu +3 more
doaj +1 more source
Nanoparticle incorporation of melittin reduces sperm and vaginal epithelium cytotoxicity. [PDF]
PLoS ONE, 2014 Melittin is a cytolytic peptide component of bee venom which rapidly integrates into lipid bilayers and forms pores resulting in osmotic lysis. While the therapeutic utility of free melittin is limited by its cytotoxicity, incorporation of melittin into ...
Andrew P Jallouk +6 more
doaj +1 more source
Opposite Regulatory Effects of Immobilized Cations on the Folding Vs. Assembly of Melittin
Frontiers in Chemistry, 2021 Ions are crucial in modulating the protein structure. For the free ions in bulk solution, ammonium is kosmotropic (structure forming) and guanidinium is chaotropic (structure breaking) to the protein structure within the Hofmeister series.
Lanlan Yu +7 more
doaj +1 more source
Cancer Nanotechnology, 2021 Background Melittin, a peptide component of honey bee venom, is an appealing candidate for cancer therapy. In the current study, melittin, melittin-loaded niosome, and empty niosome had been optimized and the anticancer effect assessed in vitro on 4T1 ...
Farnaz Dabbagh Moghaddam +7 more
doaj +1 more source
Iranian Journal of Parasitology, 2021 Background: Leishmaniasis is characterized by strong inflammatory responses with high levels of inflammatory cytokines that induce microRNA 21 and matrix metalloproteinases.
Soheila Akhzari +5 more
doaj +1 more source