Results 11 to 20 of about 10,158 (214)
On the Mechanism of Pore Formation by Melittin [PDF]
Journal of Biological Chemistry, 2008 The mechanism of pore formation of lytic peptides, such as melittin from bee venom, is thought to involve binding to the membrane surface, followed by insertion at threshold levels of bound peptide. We show that in membranes composed of zwitterionic lipids, i.e. phosphatidylcholine, melittin not only forms pores but also inhibits pore formation.
van den Bogaart, Geert +3 more
openaire +4 more sources
Molecules, 2019 Malignant melanoma is the deadliest form of skin cancer and highly chemoresistant. Melittin, an amphiphilic peptide containing 26 amino acid residues, is the major active ingredient from bee venom (BV).
Seung Ho Baek +2 more
exaly +3 more sources
Antimicrobial peptides from arthropod venoms exhibit activity against Sporothrix species [PDF]
Journal of Venomous Animals and Toxins including Tropical DiseasesBackground: Sporotrichosis is a fungal infection caused by species of the Sporothrix schenckii complex. Antifungal treatment with itraconazole and amphotericin B is limited by increasing resistance, adverse effects, and prolonged treatment courses ...
Maiara Campolina de Miranda +7 more
doaj +3 more sources
Functional reprogramming of melittin by Pluronic® F-127 enables anticancer selectivity with attenuated hemolytic activity [PDF]
Frontiers in OncologyIntroductionConventional anticancer treatments have a number of limitations, including significant toxicity to healthy cells. Therefore, it is necessary to explore new therapeutic methods and strategies that utilize bioactive compounds with high ...
Grzegorz Król +9 more
doaj +2 more sources
Melittin‐Carrying Nanoparticle Suppress T Cell‐Driven Immunity in a Murine Allergic Dermatitis Model
Advanced Science, 2023 Allergic contact dermatitis (ACD) and atopic dermatitis (AD) are the most common human skin disorders. Although corticosteroids have been widely used to treat ACD and AD, the side effects of corticosteroids encourage researchers to explore new ...
Zhihong Zhang
exaly +2 more sources
Synthesis and Evaluation of Melittin-Modified Peptides for Antibacterial Activity
ToxinsMelittin, a naturally occurring antimicrobial peptide, demonstrates broad-spectrum activity, effectively suppressing and eliminating both Gram-positive and Gram-negative bacteria, including specific drug-resistant strains.
Xiangxiang Xu +8 more
doaj +2 more sources
Effect of melittin on mice stomach
Saudi Journal of Biological Sciences, 2014 Melittin, the main bee venom component, has many positive biological effects and a relatively low toxicity in various cell types. However, there is no evidence of the effect of melittin on gastrointestinal cells. In the present study, we investigated the histological and immuonohistochemical effects of melittin on mice stomach.
Abu-Zinadah, Osama +3 more
openaire +3 more sources
Multiple Membrane Interactions and Versatile Vesicle Deformations Elicited by Melittin
Toxins, 2013 Melittin induces various reactions in membranes and has been widely studied as a model for membrane-interacting peptide; however, the mechanism whereby melittin elicits its effects remains unclear. Here, we observed melittin-induced changes in individual
Kingo Takiguchi +5 more
doaj +2 more sources
The membrane effects of melittin on gastric and colorectal cancer. [PDF]
PLoS ONE, 2019 The cytotoxic effects of melittin, a bee-venom peptide, have been widely studied towards cancer cells. Typically, these studies have examined the effect of melittin over extended-time courses (6-24 hours), meaning that immediate cellular interactions ...
Caroline Soliman +4 more
doaj +3 more sources
Animal Cells and Systems, 2022 Melittin is a major component of bee venom; it is widely used in traditional medicine because of its therapeutic effects, such as anti-inflammatory effects.
Haesoo Jung +5 more
doaj +1 more source