FcIgG-GE11-Melittin as a novel EGFR targeted peptibody with potent cytotoxic activity against cancer cells [PDF]
Scientific ReportsThe overexpression of epidermal growth factor receptor (EGFR) in various cancer types makes it an attractive target for therapeutic intervention. In this study, we designed a novel peptibody, FcIgG-GE11-Melittin, by fusing Melittin, a cytotoxic peptide ...
Malihe Hallaji +5 more
doaj +4 more sources
Administration of Apis cerana cerana melittin gene-encapsulated pectin for breast cancer therapy: an investigation of a new anti-cancer agent [PDF]
Cancer NanotechnologyPurpose One intriguing therapy option for cancer is the peptide Melittin. This study assessed the in vitro anticancer effects of Melittin, Melittin-loaded pectin, and free pectin on mammary cell lines. Methods The “thin-layer hydration approach” produced
Esmaeil Alibeigi +4 more
doaj +2 more sources
Structure and composition of supported lipid bilayers: a comparison between solvent-assisted lipid bilayer and vesicle fusion methods. [PDF]
J Appl CrystallogrNeutron reflectometry is used to compare supported lipid bilayers formed by vesicle fusion and solvent‐assisted lipid bilayer (SALB) methods, revealing structurally comparable architectures with minor differences in acyl chain thickness and low residual solvent incorporation.
Felderer B +6 more
europepmc +2 more sources
Melittin‐Carrying Nanoparticle Suppress T Cell‐Driven Immunity in a Murine Allergic Dermatitis Model
Advanced Science, 2023 Allergic contact dermatitis (ACD) and atopic dermatitis (AD) are the most common human skin disorders. Although corticosteroids have been widely used to treat ACD and AD, the side effects of corticosteroids encourage researchers to explore new ...
Zheng Liu +9 more
doaj +2 more sources
The current landscape of the antimicrobial peptide melittin and its therapeutic potential
Frontiers in ImmunologyMelittin, a main component of bee venom, is a cationic amphiphilic peptide with a linear α-helix structure. It has been reported that melittin can exert pharmacological effects, such as antitumor, antiviral and anti-inflammatory effects in vitro and in ...
Hai-Qian Zhang +3 more
doaj +3 more sources
Journal of Hematology & Oncology, 2017 Melittin is the main effective component of bee venom and has extensive biological functions; however, serious side effects have restricted its clinical application.
Jie Mao +8 more
doaj +3 more sources
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2013 Introduction: Cervical cancer is the second prevalent cancer in developing countries and the sixth prevalent cancer in USA. Since conventional treatment methods are associated with detrimental side effects, searching for new drugs using natural ...
K Pooshang Bagheri +5 more
doaj +1 more source
Impact of Honeybee Venom Melittin on Cell Viability of Different Prostate Cancer Lineages
Креативная хирургия и онкология, 2022 Background. Melittin is a major constituent of honeybee venom and comprises a water-soluble surfactant peptide with cytolytic effects potentially applicable in anticancer therapy.
R. R. Khalikov +6 more
doaj +3 more sources
Potential Inhibitory Effect of the Peptide Melittin Purified from Apis mellifera Venom on CTX-M-Type Extended-Spectrum β-Lactamases of Escherichia coli [PDF]
AntibioticsBackground. Extended-spectrum β-lactamases (ESBLs) hydrolyze nearly all β-lactam antibiotics, affecting one of the most important groups of antimicrobials used in Gram-negative infections. Among them, CTX-M is the most widespread type of ESBL. This study
Sheril Ramos-Alcántara +3 more
doaj +2 more sources
Molecules, 2019 Antimicrobial peptides (AMPs), as a key component of the immune defense systems of organisms, are a promising solution to the serious threat of drug-resistant bacteria to public health.
Jiajia Hong +5 more
doaj +3 more sources