Nanoparticle incorporation of melittin reduces sperm and vaginal epithelium cytotoxicity. [PDF]
PLoS ONE, 2014 Melittin is a cytolytic peptide component of bee venom which rapidly integrates into lipid bilayers and forms pores resulting in osmotic lysis. While the therapeutic utility of free melittin is limited by its cytotoxicity, incorporation of melittin into ...
Andrew P Jallouk +6 more
doaj +3 more sources
Melittin- and Apamin-Standardized Bee Venom: UHPLC-ESI-MS Characterization, Antibacterial Activity, and Apoptosis Induction in Human Keratinocytes. [PDF]
MoleculesBee venom (BV) is valued therapeutically mainly for its peptides, melittin and apamin. This study determined the dose-dependent biological activity of bee venom standardized to its melittin and apamin content by UHPLC-ESI-MS, as well as that of its ...
Kurek-Górecka A +9 more
europepmc +2 more sources
Molecules, 2019 Malignant melanoma is the deadliest form of skin cancer and highly chemoresistant. Melittin, an amphiphilic peptide containing 26 amino acid residues, is the major active ingredient from bee venom (BV).
Seung Ho Baek, Hye Jin Jung, Haet Lim
exaly +3 more sources
Functional reprogramming of melittin by Pluronic<sup>®</sup> F-127 enables anticancer selectivity with attenuated hemolytic activity. [PDF]
Front OncolIntroductionConventional anticancer treatments have a number of limitations, including significant toxicity to healthy cells. Therefore, it is necessary to explore new therapeutic methods and strategies that utilize bioactive compounds with high ...
Król G +7 more
europepmc +2 more sources
FcIgG-GE11-Melittin as a novel EGFR targeted peptibody with potent cytotoxic activity against cancer cells. [PDF]
Sci RepThe overexpression of epidermal growth factor receptor (EGFR) in various cancer types makes it an attractive target for therapeutic intervention. In this study, we designed a novel peptibody, FcIgG-GE11-Melittin, by fusing Melittin, a cytotoxic peptide ...
Hallaji M +5 more
europepmc +2 more sources
Animal Cells and Systems, 2022 Melittin is a major component of bee venom; it is widely used in traditional medicine because of its therapeutic effects, such as anti-inflammatory effects.
Haesoo Jung +5 more
doaj +1 more source
Melittin suppresses growth and induces apoptosis of non-small-cell lung cancer cells via down-regulation of TGF-β-mediated ERK signal pathway [PDF]
Brazilian Journal of Medical and Biological Research, 2020 The purpose of this study was to investigate the anti-cancer effect of melittin on growth, migration, invasion, and apoptosis of non-small-cell lung cancer (NSCLC) cells.
Renzhi Yu +3 more
doaj +1 more source
Opposite Regulatory Effects of Immobilized Cations on the Folding Vs. Assembly of Melittin
Frontiers in Chemistry, 2021 Ions are crucial in modulating the protein structure. For the free ions in bulk solution, ammonium is kosmotropic (structure forming) and guanidinium is chaotropic (structure breaking) to the protein structure within the Hofmeister series.
Lanlan Yu +7 more
doaj +1 more source
Delivery of Melittin as a Lytic Agent via Graphene Nanoparticles as Carriers to Breast Cancer Cells
Journal of Functional Biomaterials, 2022 Melittin, as an agent to lyse biological membranes, may be a promising therapeutic agent in the treatment of cancer. However, because of its nonspecific actions, there is a need to use a delivery method.
Karolina Daniluk +5 more
doaj +1 more source
Cancer Nanotechnology, 2021 Background Melittin, a peptide component of honey bee venom, is an appealing candidate for cancer therapy. In the current study, melittin, melittin-loaded niosome, and empty niosome had been optimized and the anticancer effect assessed in vitro on 4T1 ...
Farnaz Dabbagh Moghaddam +7 more
doaj +1 more source