Results 31 to 40 of about 10,158 (214)
PLoS ONE, 2014 Melittin is a water-soluble toxic peptide derived from the venom of the bee. Although many studies show the anti-tumor activity of melittin in human cancer including glioma cells, the underlying mechanisms remain elusive.
Hui Zhang +5 more
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The Structure of a Melittin-Stabilized Pore [PDF]
Biophysical Journal, 2015 Melittin has been reported to form toroidal pores under certain conditions, but the atomic-resolution structure of these pores is unknown. A 9-μs all-atom molecular-dynamics simulation starting from a closely packed transmembrane melittin tetramer in DMPC shows formation of a toroidal pore after 1 μs.
Leveritt, John M. +2 more
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Comparative Determination of Melittin by Capillary Electrophoretic Methods
Journal of the Turkish Chemical Society, Section A: Chemistry, 2021 Bee venom from honey bees (Apis Mellifera L.) is known to have many pharmacological and biological properties. Melittin, a peptide consisting of 26 amino acids, is known as the main component of bee venom.
Melda AKAY +3 more
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Conformational changes in melittin upon complexation with an anionic melittin analog
FEBS Letters, 1991 Melittin and its Glu‐(7,21,22,23,24) analog upon mixing in equimolar concentrations form a hybrid oligomer with significant helical structure, in conditions in which each peptide separately adopts a largely disordered structure. The hybrid exhibits both cold‐ and heat‐induced denaturations similar to the phenomena exhibited by proteins. The hybrid also
Ramalingam, Kalaiyarasi +2 more
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BMC Pharmacology and Toxicology, 2021 Background Melittin is one of the most studied antimicrobial peptides, and several in vitro experiments have demonstrated its antibacterial efficacy. However, there is evidence showing melittin has non-promising effects such as cytotoxicity and hemolysis.
Parvin Askari +3 more
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Melittin based nano drug delivery system for cancer therapy
, 2023 Melittin is a 26 amino acid polypeptide with a wide range of toxicological and pharmacological effect. It constitutes 40%-60% of dry honeybee (Apis melifera) venom.
Semanti Ghosh, Smarta Das
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Structural studies of bee melittin
Biophysical Journal, 1980 The question of how proteins refold in passing from an aqueous phase to an amphipathic environment such as a membrane is beig addressed by a structural study of bee melittin. Melittin is the toxic, main protein of bee venom, and has been shown by others to integrate into natural and synthetic membranes and to lyse a variety of cells.
Eisenberg, David +2 more
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, 2011 Antimicrobial peptides (AMPs) are naturally occurring entities with potential as pharmaceutical candidates and/or food additives. They are present in many organisms including bacteria, insects, fish and mammals.
O\u27Brien, Peter J. +12 more
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Journal of Pharmacological Sciences, 2019 Melittin is a major peptide component of sweet bee venom that possesses anti-allergic, anti-inflammatory, anti-arthritis, anti-cancer, and neuroprotective properties. However, the therapeutic effects of melittin on muscle injury have not been elucidated.
Jae Eun Lee +4 more
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Toxins, 2020 Asian honeybee venom is widely used in traditional oriental medicine. Melittin is the main component of Asian honeybee venom. In the present study, an ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QqTOF-MS ...
Sheng Huang +4 more
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