Results 31 to 40 of about 18,137 (273)
BMC Pharmacology and Toxicology, 2021 Background Melittin is one of the most studied antimicrobial peptides, and several in vitro experiments have demonstrated its antibacterial efficacy. However, there is evidence showing melittin has non-promising effects such as cytotoxicity and hemolysis.
Parvin Askari +3 more
doaj +1 more source
Structural Dynamics, 2015 Trifluoroacetic acid (TFA) may be the cause of the bottleneck in high resolution structure determination for protein-peptide complexes. Fragment based drug design often involves the use of synthetic peptides which contain TFA (excipient). Our goal was to explore the effects of this excipient on a model complex: centrin-melittin-TFA.
Pastrana Rios, Belinda +2 more
openaire +4 more sources
Journal of Apicultural Science, 2015 Two enzyme-linked immunosorbent assay (ELISA) - based detection systems: indirect competitive ELISA and biotinylated double antibody sandwich ELISA (DAS-ELISA) were developed to determine the melittin concentration in honeybee (Apis mellifera) venom and ...
Suh Lindsey Y. K. +5 more
doaj +1 more source
Molecules, 2019 Malignant melanoma is the deadliest form of skin cancer and highly chemoresistant. Melittin, an amphiphilic peptide containing 26 amino acid residues, is the major active ingredient from bee venom (BV).
Haet Nim Lim +2 more
doaj +1 more source
Structural studies of bee melittin
Biophysical Journal, 1980 The question of how proteins refold in passing from an aqueous phase to an amphipathic environment such as a membrane is beig addressed by a structural study of bee melittin. Melittin is the toxic, main protein of bee venom, and has been shown by others to integrate into natural and synthetic membranes and to lyse a variety of cells.
Eisenberg, David +2 more
openaire +2 more sources
Development of a peptide-siRNA nanocomplex targeting NF- κB for efficient cartilage delivery [PDF]
, 2019 Delivery of therapeutic small interfering RNAs (siRNAs) in an effective dose to articular cartilage is very challenging as the cartilage dense extracellular matrix renders the chondrocytes inaccessible, even to intra-articular injections. Herein, we used
Akk, Antonina +7 more
core +3 more sources
Journal of Pharmacological Sciences, 2019 Melittin is a major peptide component of sweet bee venom that possesses anti-allergic, anti-inflammatory, anti-arthritis, anti-cancer, and neuroprotective properties. However, the therapeutic effects of melittin on muscle injury have not been elucidated.
Jae Eun Lee +4 more
doaj +1 more source
A genomic approach highlights common and diverse effects and determinants of susceptibility on the yeast Saccharomyces cerevisiae exposed to distinct antimicrobial peptides [PDF]
, 2010 Background: The mechanism of action of antimicrobial peptides (AMP) was initially correlated with peptide membrane permeation properties. However, recent evidences indicate that action of a number of AMP is more complex and involves specific interactions
Carmona, Lourdes +5 more
core +3 more sources
Nature of Melittin-Phospholipid Interaction
Biophysical Journal, 1982 Melittin, the major protein component of bee venom that possesses a strong hemolytic activity (1), is an amphipathic protein whose amino acid residues 1-20 are predominantly hydrophobic; residues 21-26 are hydrophilic. Determination of the molecular basis and specificity of the attractive forces involved in its interaction with membranes is essential ...
Georghiou, S. +2 more
openaire +2 more sources
Toxins, 2020 Asian honeybee venom is widely used in traditional oriental medicine. Melittin is the main component of Asian honeybee venom. In the present study, an ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QqTOF-MS ...
Sheng Huang +4 more
doaj +1 more source