Results 21 to 30 of about 7,897 (182)
Delivery of Melittin as a Lytic Agent via Graphene Nanoparticles as Carriers to Breast Cancer Cells
Journal of Functional Biomaterials, 2022 Melittin, as an agent to lyse biological membranes, may be a promising therapeutic agent in the treatment of cancer. However, because of its nonspecific actions, there is a need to use a delivery method.
Karolina Daniluk +5 more
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A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin
Journal of Venomous Animals and Toxins including Tropical Diseases, 2022 Background: Melittin has shown antiproliferative effects on tumor cells. Therefore, it comprises a valuable compound for studies on cancer treatment. To the best of our knowledge, no studies have reported melittin effects on bone metastasis.
Mackson Martins Rocha +9 more
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Emulsion-Based Intradermal Delivery of Melittin in Rats
Molecules, 2017 Bee venom (BV) has long been used as a traditional medicine. The aim of the present study was to formulate a BV emulsion with good rheological properties for dermal application and investigate the effect of formulation on the permeation of melittin ...
Sang Mi Han, Se Gun Kim, Sok Cheon Pak
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Comparative Determination of Melittin by Capillary Electrophoretic Methods
Journal of the Turkish Chemical Society, Section A: Chemistry, 2021 Bee venom from honey bees (Apis Mellifera L.) is known to have many pharmacological and biological properties. Melittin, a peptide consisting of 26 amino acids, is known as the main component of bee venom.
Melda AKAY +3 more
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EFFECT OF MELITTIN AND THEPAX AS NATURAL ALTERNATIVES TO TRADITIONAL ANTIMICROBIAL AND ANTIVIRAL TREATMENTS ON BROILER PERFORMANCE AND SOME RELATED TRAITS [PDF]
Egyptian Poultry Science, 2021 The present study was performed to evaluate the untraditional natural additives (Melittin and Thepax) as prospective alternatives to classical therapy treatment through studying their effects on productive performance, carcass characteristics, meat ...
mohamed ibrahim el-malky +4 more
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The structure of melittin in membranes
Biophysical Journal, 1986 The conformation of the polypeptide melittin in lipid membranes as determined by Raman spectroscopy is a bent alpha-helix formed by the mainly hydrophobic residues 1-21, and a nonhelical COOH-terminal segment of the hydrophilic residues 22-26. Fluorescence quenching experiments on residue Trp19 reveal that all COOH-termini are located on that side of a
Vogel, Horst, Jaehnig, Fritz
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PLoS ONE, 2014 Melittin is a water-soluble toxic peptide derived from the venom of the bee. Although many studies show the anti-tumor activity of melittin in human cancer including glioma cells, the underlying mechanisms remain elusive.
Hui Zhang +5 more
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On the Mechanism of Pore Formation by Melittin [PDF]
Journal of Biological Chemistry, 2008 The mechanism of pore formation of lytic peptides, such as melittin from bee venom, is thought to involve binding to the membrane surface, followed by insertion at threshold levels of bound peptide. We show that in membranes composed of zwitterionic lipids, i.e. phosphatidylcholine, melittin not only forms pores but also inhibits pore formation.
van den Bogaart, Geert +3 more
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Conformational changes in melittin upon complexation with an anionic melittin analog
FEBS Letters, 1991 Melittin and its Glu‐(7,21,22,23,24) analog upon mixing in equimolar concentrations form a hybrid oligomer with significant helical structure, in conditions in which each peptide separately adopts a largely disordered structure. The hybrid exhibits both cold‐ and heat‐induced denaturations similar to the phenomena exhibited by proteins. The hybrid also
Ramalingam, Kalaiyarasi +2 more
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The Structure of a Melittin-Stabilized Pore [PDF]
Biophysical Journal, 2015 Melittin has been reported to form toroidal pores under certain conditions, but the atomic-resolution structure of these pores is unknown. A 9-μs all-atom molecular-dynamics simulation starting from a closely packed transmembrane melittin tetramer in DMPC shows formation of a toroidal pore after 1 μs.
Leveritt, John M. +2 more
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