Melittin suppresses growth and induces apoptosis of non-small-cell lung cancer cells via down-regulation of TGF-β-mediated ERK signal pathway [PDF]
Brazilian Journal of Medical and Biological Research, 2020 The purpose of this study was to investigate the anti-cancer effect of melittin on growth, migration, invasion, and apoptosis of non-small-cell lung cancer (NSCLC) cells.
Renzhi Yu +3 more
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Cancer Nanotechnology, 2021 Background Melittin, a peptide component of honey bee venom, is an appealing candidate for cancer therapy. In the current study, melittin, melittin-loaded niosome, and empty niosome had been optimized and the anticancer effect assessed in vitro on 4T1 ...
Farnaz Dabbagh Moghaddam +7 more
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Opposite Regulatory Effects of Immobilized Cations on the Folding Vs. Assembly of Melittin
Frontiers in Chemistry, 2021 Ions are crucial in modulating the protein structure. For the free ions in bulk solution, ammonium is kosmotropic (structure forming) and guanidinium is chaotropic (structure breaking) to the protein structure within the Hofmeister series.
Lanlan Yu +7 more
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Delivery of Melittin as a Lytic Agent via Graphene Nanoparticles as Carriers to Breast Cancer Cells
Journal of Functional Biomaterials, 2022 Melittin, as an agent to lyse biological membranes, may be a promising therapeutic agent in the treatment of cancer. However, because of its nonspecific actions, there is a need to use a delivery method.
Karolina Daniluk +5 more
doaj +1 more source
Iranian Journal of Parasitology, 2021 Background: Leishmaniasis is characterized by strong inflammatory responses with high levels of inflammatory cytokines that induce microRNA 21 and matrix metalloproteinases.
Soheila Akhzari +5 more
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A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin
Journal of Venomous Animals and Toxins including Tropical Diseases, 2022 Background: Melittin has shown antiproliferative effects on tumor cells. Therefore, it comprises a valuable compound for studies on cancer treatment. To the best of our knowledge, no studies have reported melittin effects on bone metastasis.
Mackson Martins Rocha +9 more
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Melittin interaction with sulfated sugars and cell membranes [PDF]
, 2008 The presented work focused on an alternative mechanism of action of melittin on the cell membranes. The study using ITC reveals that melittin has a high affinity for several glycosaminoglycans (GAGs), i.e.
Klocek, Gabriela
core +1 more source
Anionically-functionalized glycogen encapsulates melittin by multivalent interactions
, 2022 We developed acid-functionalized glycogen conjugates as supramolecular carriers for efficient encapsulation and inhibition of a model cationic peptide melittin - the main component of honeybee venom.
Marcela, Filipová +12 more
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Melittin-induced metabolic changes on the Madin-Darby Bovine Kidney cell line
, 2021 In this study, the toxic effects of melittin on Madin-Darby Bovine Kidney cells (MDBK) were analyzed with respect to mitochondrial functionality by reduction of MTT and flow cytometry, apoptosis potential, necrosis, oxygen reactive species (ROS ...
L.S. Barcelos (10387555) +9 more
core +1 more source
EFFECT OF MELITTIN AND THEPAX AS NATURAL ALTERNATIVES TO TRADITIONAL ANTIMICROBIAL AND ANTIVIRAL TREATMENTS ON BROILER PERFORMANCE AND SOME RELATED TRAITS [PDF]
Egyptian Poultry Science, 2021 The present study was performed to evaluate the untraditional natural additives (Melittin and Thepax) as prospective alternatives to classical therapy treatment through studying their effects on productive performance, carcass characteristics, meat ...
mohamed ibrahim el-malky +4 more
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