Results 21 to 30 of about 11,509 (217)
Melittin interaction with sulfated sugars and cell membranes [PDF]
, 2008 The presented work focused on an alternative mechanism of action of melittin on the cell membranes. The study using ITC reveals that melittin has a high affinity for several glycosaminoglycans (GAGs), i.e.
Klocek, Gabriela
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High content analysis to determine cytotoxicity of the antimicrobial peptide, melittin and selected structural analogs [PDF]
, 2011 Antimicrobial peptides (AMPs) are naturally occurring entities with potential as pharmaceutical candidates and/or food additives. They are present in many organisms including bacteria, insects, fish and mammals.
O\u27Brien, Peter J. +12 more
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Melittin-induced metabolic changes on the Madin-Darby Bovine Kidney cell line
, 2021 In this study, the toxic effects of melittin on Madin-Darby Bovine Kidney cells (MDBK) were analyzed with respect to mitochondrial functionality by reduction of MTT and flow cytometry, apoptosis potential, necrosis, oxygen reactive species (ROS ...
L.S. Barcelos (10387555) +9 more
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Emulsion-Based Intradermal Delivery of Melittin in Rats
Molecules, 2017 Bee venom (BV) has long been used as a traditional medicine. The aim of the present study was to formulate a BV emulsion with good rheological properties for dermal application and investigate the effect of formulation on the permeation of melittin ...
Sang Mi Han, Se Gun Kim, Sok Cheon Pak
doaj +1 more source
PLoS ONE, 2014 Melittin is a water-soluble toxic peptide derived from the venom of the bee. Although many studies show the anti-tumor activity of melittin in human cancer including glioma cells, the underlying mechanisms remain elusive.
Hui Zhang +5 more
doaj +1 more source
EFFECT OF MELITTIN AND THEPAX AS NATURAL ALTERNATIVES TO TRADITIONAL ANTIMICROBIAL AND ANTIVIRAL TREATMENTS ON BROILER PERFORMANCE AND SOME RELATED TRAITS [PDF]
Egyptian Poultry Science, 2021 The present study was performed to evaluate the untraditional natural additives (Melittin and Thepax) as prospective alternatives to classical therapy treatment through studying their effects on productive performance, carcass characteristics, meat ...
mohamed ibrahim el-malky +4 more
doaj +1 more source
The structure of melittin in membranes
Biophysical Journal, 1986 The conformation of the polypeptide melittin in lipid membranes as determined by Raman spectroscopy is a bent alpha-helix formed by the mainly hydrophobic residues 1-21, and a nonhelical COOH-terminal segment of the hydrophilic residues 22-26. Fluorescence quenching experiments on residue Trp19 reveal that all COOH-termini are located on that side of a
Vogel, Horst, Jaehnig, Fritz
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BMC Pharmacology and Toxicology, 2021 Background Melittin is one of the most studied antimicrobial peptides, and several in vitro experiments have demonstrated its antibacterial efficacy. However, there is evidence showing melittin has non-promising effects such as cytotoxicity and hemolysis.
Parvin Askari +3 more
doaj +1 more source
A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin
Journal of Venomous Animals and Toxins including Tropical Diseases, 2022 Background: Melittin has shown antiproliferative effects on tumor cells. Therefore, it comprises a valuable compound for studies on cancer treatment. To the best of our knowledge, no studies have reported melittin effects on bone metastasis.
Mackson Martins Rocha +9 more
doaj +1 more source
Conformational changes in melittin upon complexation with an anionic melittin analog
FEBS Letters, 1991 Melittin and its Glu‐(7,21,22,23,24) analog upon mixing in equimolar concentrations form a hybrid oligomer with significant helical structure, in conditions in which each peptide separately adopts a largely disordered structure. The hybrid exhibits both cold‐ and heat‐induced denaturations similar to the phenomena exhibited by proteins. The hybrid also
Ramalingam, Kalaiyarasi +2 more
openaire +2 more sources