AP-UV-MALDI mit flüssigen Matrizes: stabile Ionenausbeuten von mehrfach geladenen Peptid- und Proteinionen für die empfindliche Massenspektrometrie [PDF]
, 2013 In der biologischen Massenspektrometrie (MS) werden überwiegend zwei Ionisationstechniken für die Analyse von grçßeren Biomolekfürlen wie Polypeptiden eingesetzt.
Cramer +22 more
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The Clinical Respiratory JournalIn previous studies, we developed a novel fusion protein named “melittin‐MIL‐2” which exhibited more anti‐tumor activity. However, it remains unclear whether melittin‐MIL‐2 possesses antitumor immune effect on lung adenocarcinoma.
Weize Gao +4 more
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Coupling hydrophobic, dispersion, and electrostatic contributions in continuum solvent models [PDF]
, 2005 Recent studies of the hydration of micro- and nanoscale solutes have demonstrated a strong {\it coupling} between hydrophobic, dispersion and electrostatic contributions, a fact not accounted for in current implicit solvent models.
H. S. Ashbaugh +4 more
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Toxins, 2015 Cholangiopathy is a chronic immune-mediated disease of the liver, which is characterized by cholangitis, ductular reaction and biliary-type hepatic fibrosis. There is no proven medical therapy that changes the course of the disease.
Kyung-Hyun Kim +7 more
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Peptide-siRNA nanocomplexes targeting NF-κB subunit p65 suppress nascent experimental arthritis [PDF]
, 2014 The NF-κB signaling pathway is implicated in various inflammatory diseases, including rheumatoid arthritis (RA); therefore, inhibition of this pathway has the potential to ameliorate an array of inflammatory diseases.
Agarwal +20 more
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Nucleic Acid Carriers Based on Precise Polymer Conjugates [PDF]
, 2011 Polymer polydispersity, random conjugation of functional groups, and poorly understood structure–activity relationships have constantly hampered progress in the development of nucleic acid carriers.
Troiber, Christina, Wagner, Ernst
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Functional analysis of the Escherichia coli mrdA gene in melittin resistance
Frontiers in MicrobiologyObjectiveThe aim of this study is to examine the functional role and resistance mechanisms of the Escherichia coli (E. coli) peptidoglycan transpeptidase gene, mrdA, in resistance to melittin.MethodsThe resistance of E.
Chong-Yi Zhao +5 more
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Kinetics and mechanism of hemolysis induced by melittin and by a synthetic melittin analogue
Biophysical Journal, 1982 The cytotoxic peptide from honeybee venom, melittin, and a synthetic peptide analogue of it lyse human erythrocytes in a biphasic process. The kinetics of the lysis in 0.30 M sucrose, 0.01 M sodium phosphate, pH 7.30 at 4 degrees C were investigated. Our results show that melittin rapidly binds to the outer surface of the erythrocyte membrane, and the ...
DeGrado, W.F. +4 more
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Lateral flow (immuno)assay: its strengths, weaknesses, opportunities and threats. A literature survey [PDF]
Lateral flow (immuno)assays are currently used for qualitative, semiquantitative and to some extent quantitative monitoring in resource-poor or non-laboratory environments.
Amerongen, A., van +2 more
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Metabolomic profiling of the synergistic effects of melittin in combination with cisplatin on ovarian cancer cells [PDF]
, 2017 Melittin, the main peptide present in bee venom, has been proposed as having potential for anticancer therapy; the addition of melittin to cisplatin, a first line treatment for ovarian cancer, may increase the therapeutic response in cancer treatment via
Alonezi, Sanad +10 more
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