Results 101 to 110 of about 10,158 (214)

Redox-Sensitive Nanocomplex for Targeted Delivery of Melittin

, 2020
Although peptide therapeutics have been explored for decades, the successful delivery of potent peptides in vitro and in vivo remains challenging due to the poor stability, low cell permeability, and off-target effects.
Cheng, Bei, Peisheng Xu, Bei Cheng, Xu, Peisheng   +3 more
core   +1 more source

Isolation of Melittin from Iranian Honey Bee Venom and Investigation of Its Effect on Proliferation of Cervical Cancer- HeLa Cell Line

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2013
Introduction: Cervical cancer is the second prevalent cancer in developing countries and the sixth prevalent cancer in USA. Since conventional treatment methods are associated with detrimental side effects, searching for new drugs using natural ...
K Pooshang Bagheri, A Mahmoodzadeh, H Zarinnahad, M Mahdavi, D Shahbazzadeh, A Moradi   +5 more
doaj  

Interaction of Melittin Peptides with Perfluorocarbon Nanoemulsion Particles

, 2016
Melittin, an antimicrobial peptide, forms pores in biological membranes and triggers cell death. Therefore, it has potential as an anticancer therapy.
Paul H. Schlesinger (1318359), Nathan A. Baker (361291), Samuel A. Wickline (585136), Sun-Joo Lee (2132536), Gregory M. Lanza (132368)   +4 more
core   +1 more source

Effects of 1-butyl-3-methyl-imidazolium acetate on the solution behavior of melittin: A molecular dynamics study

Journal of Ionic Liquids
Ionic liquids posses efficiency as solvents, co-solvents or agents for applications involving biomolecules. Due to the increasing interest in systems containing proteins and ionic liquids, we hereby present results from molecular dynamics simulations on ...
Jessé Neumann, Hubert K. Stassen
doaj   +1 more source

Probing the steric barrier of nonionic surfactant vesicles with melittin

, 2008
The role of the surface polymer brush of nonionic surfactant vesicles (NSV) in inhibiting interactions with small membrane-perturbing molecules was investigated using the bee venom peptide melittin as a probe. The interaction between melittin and NSV was
Harvey, Richard D., Lawrence, M. Jayne, Bui, Tam T.   +2 more
core   +1 more source

Melittin alleviates sepsis-induced acute kidney injury by promoting GPX4 expression to inhibit ferroptosis

Redox Report
Objectives: Melittin, the main component of bee venom, is a natural anti-inflammatory substance, in addition to its ability to fight cancer, antiviral, and useful in diabetes treatment.
Hongyan Zan, Jizheng Liu, Meixia Yang, Honghui Zhao, Chunyan Gao, Yunyan Dai, Zhiming Wang, Hongxuan Liu, Yunfei Zhang   +8 more
doaj   +1 more source

Melittin alcalase-hydrolysate: a novel chemically characterized multifunctional bioagent; antibacterial, anti-biofilm and anticancer

Frontiers in Microbiology
The prevalent life-threatening microbial and cancer diseases and lack of effective pharmaceutical therapies created the need for new molecules with antimicrobial and anticancer potential.
Samia E. El-Didamony, Mohamed H. Kalaba, Mohamed H. Sharaf, Esmail M. El-Fakharany, Esmail M. El-Fakharany, Esmail M. El-Fakharany, Ali Osman, Ali Osman, Ali Osman, Mahmoud Sitohy, Basel Sitohy, Basel Sitohy   +11 more
doaj   +1 more source

Incorporation of Melittin Enhances Interfacial Fluidity of Bicontinuous Microemulsions

, 2019
The effect of an antimicrobial peptide, melittin, on the long-range collective and local undulation motions of bicontinuous microemulsions (BμEs) was evaluated using dynamic light scattering (DLS) and neutron spin echo (NSE) spectroscopy.
V. S. Urban, V. K. Sharma, V. S. Urban (2829845), M. Ohl, S. Gupta (756659), S. V. Pingali (6551984), H. M. O’Neill, H. M. O’Neill (6551981), S. Gupta, S. V. Pingali, E. Mamontov, V. K. Sharma (1617775), D. G. Hayes, E. Mamontov (2730112), D. G. Hayes (6551978), M. Ohl (4766031)   +15 more
core   +1 more source

Potential Inhibitory Effect of the Peptide Melittin Purified from Apis mellifera Venom on CTX-M-Type Extended-Spectrum β-Lactamases of Escherichia coli

Antibiotics
Background. Extended-spectrum β-lactamases (ESBLs) hydrolyze nearly all β-lactam antibiotics, affecting one of the most important groups of antimicrobials used in Gram-negative infections. Among them, CTX-M is the most widespread type of ESBL. This study
Sheril Ramos-Alcántara, María Alejandra Cornejo Napan, Giovanni Lopez Campana, Jesus Tamariz   +3 more
doaj   +1 more source

Molecular Simulations of Melittin-Induced Membrane Pores

, 2017
Membrane-active peptides (MAPs) are able to induce pores in cell membranes via molecular mechanisms, which are still subject to ongoing research. In this work, we present molecular dynamics simulations that suggest a precursor membrane defect plays an ...
Woodward, Clifford E., Jan Forsman, Sun, Delin, Delin Sun, Clifford E. Woodward, Forsman, Jan   +5 more
core   +1 more source