Results 91 to 100 of about 10,158 (214)

A hope for ineffective antibiotics to return to treatment: investigating the anti-biofilm potential of melittin alone and in combination with penicillin and oxacillin against multidrug resistant-MRSA and -VRSA

Frontiers in Microbiology
BackgroundThe emergence and rapid spread of multi-drug resistant (MDR) bacterial strains, such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant S.
Saba Jalalifar, Saba Jalalifar, Shabnam Razavi, Shabnam Razavi, Rasoul Mirzaei, Gholamreza Irajian, Gholamreza Irajian, Kamran Pooshang Bagheri   +7 more
doaj   +1 more source

Peptides as a Therapeutic Alternative Against Leishmaniasis: A Scoping Review

Chemical Biology &Drug Design, Volume 107, Issue 5, May 2026.
This scoping review of 79 studies identified 231 antimicrobial peptides with anti‐Leishmania activity, including natural‐derived and synthetic peptides (inspired by natural sources or developed through rational design). Most were evaluated in vitro against promastigote and/or amastigote forms, with synthetic peptides showing a more promising effect ...
Maria Eduarda da Veiga Oliveira, Ellen Dyminski Parente Ribeiro, Otávio Henrique Pradi Guenther, Fernanda Tomiotto‐Pellissier   +3 more
wiley   +1 more source

In Vivo Wound Healing Effects of Antimicrobial Peptide‐Based Dressings for S. aureus‐Infected Wounds—A Systematic Review and Meta‐Analysis

Wound Repair and Regeneration, Volume 34, Issue 3, May/June 2026.
ABSTRACT The purpose of this systematic review was to determine whether the addition of antimicrobial peptides (AMPs) to dressing materials enhances their wound healing capabilities when applied to S. aureus‐infected wounds in rodent models. The primary objective was not to derive definitive efficacy conclusions, but to systematically assess the ...
Lea Rodge, Artemis Stamboulis, Sarah A. Kuehne, Melissa M. Grant, Zubair Ahmed   +4 more
wiley   +1 more source

Cholesterol inhibits the lytic activity of melittin in erythrocytes

, 2005
Although cell lysis by the hemolytic peptide, melittin, has been extensively studied, the role of specific lipids of the erythrocyte membrane on melittin-induced hemolysis remains unexplored.
Chattopadhyay, Amitabha, Raghuraman, H.
core   +1 more source

Melittin-Grafted HPMA-Oligolysine Based Copolymers for Gene Delivery

, 2013
Non-viral gene delivery systems capable of transfecting cells in the brain are critical in realizing the potential impact of nucleic acid therapeutics for diseases of the central nervous system.
Sellers, Drew L., Joan G. Schellinger, Chu, David S. H., Schellinger, Joan G., Philip J. Horner, Johnson, Russell N., David S.H. Chu, Stayton, Patrick S., Patrick S. Stayton, Don O. Maris, Convertine, Anthony J., Joshuel A. Pahang, Pahang, Joshuel A., Maris, Don O., Suzie H. Pun, Pun, Suzie H., Anthony J. Convertine, Drew L. Sellers, Horner, Philip J., Russell N. Johnson   +19 more
core   +1 more source

Melittin binding to mixed phosphatidylglycerol/phosphatidylcholine membranes

, 1990
The binding of bee venom melittin to negatively charged unilamellar vesicles and planar lipid bilayers composed of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol (POPG) was studied with ...
Seelig, J., Beschiaschvili, G.
core  

Pharmacological evaluation of bee venom and melittin

, 2014
The objective of this study was to identify the pharmacological effects of bee venom and its major component, melittin, on the nervous system of mice. For the pharmacological analysis, mice were treated once with saline, 0.1 or 1.2mg/kg of bee venom and ...
Reis, Francisco P., da Paixão, Ailma O., Júnior, Waldecy de L., Dantas, Camila G., Gomes, Margarete Z., Gramacho, Kátia P., Nunes, Tássia L.G.M., Nunes, Tâmara L.G.M., Cardoso, Juliana C.   +8 more
core   +1 more source

The Novel Fusion Protein Melittin‐MIL‐2 Exhibits Strong Antitumor Immune Effect in Lung Adenocarcinoma Cell A549

The Clinical Respiratory Journal
In previous studies, we developed a novel fusion protein named “melittin‐MIL‐2” which exhibited more anti‐tumor activity. However, it remains unclear whether melittin‐MIL‐2 possesses antitumor immune effect on lung adenocarcinoma.
Weize Gao, Wenshuai Li, Zhan Wang, Yongxin Li, Mingjun Liu   +4 more
doaj   +1 more source

Effects of Melittin Treatment in Cholangitis and Biliary Fibrosis in a Model of Xenobiotic-Induced Cholestasis in Mice

Toxins, 2015
Cholangiopathy is a chronic immune-mediated disease of the liver, which is characterized by cholangitis, ductular reaction and biliary-type hepatic fibrosis. There is no proven medical therapy that changes the course of the disease.
Kyung-Hyun Kim, Hyun-Jung Sung, Woo-Ram Lee, Hyun-Jin An, Jung-Yeon Kim, Sok Cheon Pak, Sang-Mi Han, Kwan-Kyu Park   +7 more
doaj   +1 more source

Functional analysis of the Escherichia coli mrdA gene in melittin resistance

Frontiers in Microbiology
ObjectiveThe aim of this study is to examine the functional role and resistance mechanisms of the Escherichia coli (E. coli) peptidoglycan transpeptidase gene, mrdA, in resistance to melittin.MethodsThe resistance of E.
Chong-Yi Zhao, Xiao Li, Ting Zhao, Ying Liu, Xue-Shan Xia, Xiao-Mei Wu   +5 more
doaj   +1 more source