Liquid AP-UV-MALDI enables stable ion yields of multiply charged peptide and protein ions for sensitive analysis by mass spectrometry [PDF]
, 2013 In biological mass spectrometry (MS), two ionization techniques are predominantly employed for the analysis of larger biomolecules, such as polypeptides.
Cramer, Rainer +3 more
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Artificial lipidation of proteins and peptides: from mechanism to clinical applications
The FEBS Journal, Volume 293, Issue 5, Page 1269-1284, March 2026.Artificial lipidation transforms protein and peptide therapeutics by attaching fatty acid chains through reversible or permanent chemical strategies. This biomimetic approach delivers four key therapeutic advantages: extended circulation times (enabling weekly instead of daily dosing), alternative administration routes including oral delivery, precise ...
Jiaming Mu, Emily Vong, Sheiliza Carmali
wiley +1 more source
Potentiality of raloxifene loaded melittin functionalized lipidic nanovesicles against pancreatic cancer cells [PDF]
, 2022 Usama A. Fahmy +9 more
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Bottom‐up Strategies for Generating Polymer Protocells That Mimic Cellular Communication
Chemistry – A European Journal, Volume 32, Issue 8, 23 February 2026.This review focuses on polymeric protocells produced using a bottom‐up approach. Polymer‐based assemblies guarantee stability and designability by adjusting the properties of the amphiphilic copolymers used. The review covers protocell architectures, production, and their intra‐ and intercellular communication mechanisms.
Gloria Saorin +3 more
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Frontiers in MicrobiologyBackgroundThe emergence and rapid spread of multi-drug resistant (MDR) bacterial strains, such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant S.
Saba Jalalifar +7 more
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Pore formation and translocation of melittin
Biophysical Journal, 1997 Melittin, a bee venom, is a basic amphiphilic peptide, which mainly acts on the lipid matrix of membranes, lysing various cells. To elucidate the molecular mechanism, we investigated its interactions with phospholipid vesicles. The peptide formed a pore with a short lifetime in the membrane, as revealed by the release of an anionic fluorescent dye ...
Matsuzaki, K. +2 more
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Antiviral activity of animal venom peptides and related compounds [PDF]
, 2017 Viruses exhibit rapid mutational capacity to trick and infect host cells, sometimes assisted through virus-coded peptides that counteract host cellular immune defense.
Mata, Élida Cleyse Gomes da Mata +3 more
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The membrane effects of melittin on gastric and colorectal cancer.
PLoS ONE, 2019 The cytotoxic effects of melittin, a bee-venom peptide, have been widely studied towards cancer cells. Typically, these studies have examined the effect of melittin over extended-time courses (6-24 hours), meaning that immediate cellular interactions ...
Caroline Soliman +4 more
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The role of hydrophobic amino acid grafts in the enhancement of membrane-disruptive activity of pH-responsive pseudo-peptides [PDF]
, 2009 pH-responsive polymers have been synthesised by grafting l-valine (PV-75), l-leucine (PL-75) and l-phenylalanine (PP-75) onto the pendant carboxylic acid moieties of a pseudo-peptide, poly(l-lysine iso-phthalamide), at a stoichiometric degree of ...
Chen, R +3 more
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The structure of melittin in membranes
Biophysical Journal, 1986 The conformation of the polypeptide melittin in lipid membranes as determined by Raman spectroscopy is a bent alpha-helix formed by the mainly hydrophobic residues 1-21, and a nonhelical COOH-terminal segment of the hydrophilic residues 22-26. Fluorescence quenching experiments on residue Trp19 reveal that all COOH-termini are located on that side of a
Vogel, H., Jähnig, F.
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