Results 71 to 80 of about 11,509 (217)

Melittin as a safe compound to BALB/c mice immune system; a tiered approach immunotoxicity screening

BMC Complementary Medicine and Therapies, 2023
Background Maintenance of immune system integrity is a vital requirement to protect human body against pathogens/cancers. Natural compounds have long been used due to their benefits for the immune system. One of which is bee venom that contains a peptide
Gholamreza Karimi, Sina Fatemi, Bahram Memar, Mohammad-Bagher Khorrami, Arian Amali, Mahmood Sadeghi, Seyed-Alireza Esmaeili, Bamdad Riahi-Zanjani   +7 more
doaj   +1 more source

Bioactive peptides in cancer and inflammation: Mechanisms, model systems and clinical translation

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Bioactive peptides (BAPs) derived from host, marine, insect, plant and synthetic sources share cationic, amphipathic structures adopting α‐helical, β‐sheet or cyclic conformations. These features underlie anti‐cancer effects, including membrane disruption, apoptosis and cell‐cycle arrest, anti‐metastatic activity, reduced invasion and migration, and ...
Najwa Doha, Richa Gill, Sergio Crovella, Haissam Abou‐Saleh, Sahar Isa Da'as   +4 more
wiley   +1 more source

SiO2–alginate–melittin nano-conjugates suppress the proliferation of ovarian cancer cells: a controlled release approach leveraging alginate lyase

Cancer Nanotechnology
Background Ovarian cancer treatment is challenged by resistance and off-target effects. Melittin shows promise against cancer but is limited by its instability and harmful cellular interactions. Our study introduces SiO2–alginate–melittin nano-conjugates
Lihui Si, Shuli Yang, Ruixin Lin, Shiyu Gu, Chuhan Yan, Jia Yan   +5 more
doaj   +1 more source

A novel melittin nano-liposome exerted excellent anti-hepatocellular carcinoma efficacy with better biological safety

Journal of Hematology & Oncology, 2017
Melittin is the main effective component of bee venom and has extensive biological functions; however, serious side effects have restricted its clinical application.
Jie Mao, Shujun Liu, Min Ai, Zhuo Wang, Duowei Wang, Xianjing Li, Kaiyong Hu, Xinghua Gao, Yong Yang   +8 more
doaj   +1 more source

Peptide‐Enabled Nanoplatforms for Malaria and Leishmaniasis: From Intracellular Targeting to Translational Diagnostic Perspectives

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
Peptide‐enabled nanoplatforms offer multifunctional strategies for the treatment and diagnosis of malaria and leishmaniasis. Liposomal, polymeric, and metallic nanocarriers, together with cell‐penetrating peptides and parasite‐derived mimotopes, can improve targeted drug delivery, stability, bioavailability, and intracellular localization.
Christian S. Carnero Canales, Ana Clara Lunardi Yagi, Túlio Custódio Reis, Jessica Ingrid Cazorla, Jade Rojas Villar, Marcia A. Graminha, Roxana Yesenia Pastrana Alta, Fernando Rogério Pavan   +7 more
wiley   +1 more source

HPLC chromatograms and amount of melittin, PLA2 and histamine.

, 2016
(A) HPLC chromatograms of melittin (tR 17.8 min), PLA2 (tR 14.2 min) and (B) histamine (tR 4.58 min) (C) The amount of melittin, PLA2, and histamine in BV and eBV.
Sang Kook Lee (758686), Joon-Shik Shin (587176), Won Kyung Kim (758682), Wonil Koh (326945), Jae-woong Lee (3387848), In-Hyuk Ha (587172), Eun Jee Kim (3387845), Hwa-Jin Chung (2084740), In-Hee Lee (115638), Me-riong Kim (587174), Min-Jeong Kim (222317), Jinho Lee (587173), Yoon Jae Lee (2192230)   +12 more
core   +1 more source

Isolating Melittin from Bee Venom and Evaluating its Effect on Proliferation of Gastric Cancer Cells

Basic & Clinical Cancer Research, 2013
Background : Gastric cancer (GC) is one of the most common cancers worldwide and in Iran. As conventional therapies such as surgery and chemotherapy are invasive with adverse effects, current studies are important as they are conducted to find natural ...
Amir Mahmoodzadeh, Ali Morady, Hannaneh Zarrinnahad, Kamran Pooshang Bagheri, Pooria Ghasemi-Dehkordi, Mahdi Mahdavi, Delavar Shahbazzadeh, Hamidreza Shahmorady   +7 more
doaj  

Antimicrobial and antibiofilm effects of melittin and apamin bee venoms from apis mellifera l. on eskape pathogens and cytotoxic effects on l929 fibroblast cells [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi
Public health is facing a worldwide challenge due to the emergence of multiple antibiotic resistance in ESKAPE (Enterococcus faecalis, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Escherichia coli ...
Elif AYDIN, Sema CETİNKAYA, Meliha KOLDEMİR GÜNDÜZ, Ayşe KOÇAK SEZGİN   +3 more
doaj   +1 more source

Multiple Organ‐Dysfunction Secondary to Multiple Bee Sting: A Case Report From Tanzania

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT An 8‐year‐old boy sustained over 200 bee stings, developing airway‐threatening facial oedema requiring intubation and ICU admission, with severe anemia (Hb 3.2 g/dL), rhabdomyolysis, intravascular haemolysis and marked hepatic injury (AST 2505 U/L), yet preserved renal function.
Kelvin M. Musa, Auson Albert, Jane G. Zakaria, Ronald G. Mbwasi, Anorld David, Elton Meleki   +5 more
wiley   +1 more source

Melittin interaction with sulfated cell surface sugars

, 2008
Melittin is a 26-residue cationic peptide with cytolytic and antimicrobial properties. Studies on the action mechanism of melittin have focused almost exclusively on the membrane-perturbing properties of this peptide, investigating in detail the melittin-
Klocek, Gabriela, Seelig, Joachim, Seelig J, Klocek G   +3 more
core   +1 more source