Results 71 to 80 of about 18,137 (273)

Redox‐Responsive Polymeric Nanocapsules for Enhanced Tumor‐Targeted Delivery of Antimicrobial Peptides

Advanced Science, Volume 13, Issue 24, 27 April 2026.
This study presents a modular redox‐responsive nanocapsule platform that enables enhanced tumor‐targeted delivery of antimicrobial peptides. Using melittin as an example, the system achieves controlled activation within the tumor microenvironment, improving intratumoral accumulation while minimizing systemic toxicity.
Lin Tang, Yajian Li, Xiaoyin Lv, Jianmei Guo, Yijia Zhang, Yuqi Lin, Kaili Nie, Jian Zeng, Ming Zhang, Qiong Dai   +9 more
wiley   +1 more source

Calmodulin in Complex with Proteins and Small Molecule Ligands: Operating with the Element of Surprise. Implications for Structure-Based Drug Design [PDF]

, 2009
Calmodulin plays a role in several life processes, its flexibility allows binding of a number of different ligands from small molecules to amphiphilic peptide helices and proteins. Through the diversity of its functions, it is quite difficult to find new
Keserű, György Miklós, Menyhárd, D.K., Náray-Szabó, Gábor   +2 more
core  

Melittin Tryptophan Substitution with a Fluorescent Amino Acid Reveals the Structural Basis of Selective Antitumor Effect and Subcellular Localization in Tumor Cells

Toxins, 2022
Melittin is a membrane-active peptide with strong anticancer activity against various cancers. Despite decades of research, the role of the singular Trp in the anticancer activity and selectivity of melittin remains poorly understood.
Yonghui Lv, Xu Chen, Zhidong Chen, Zhanjun Shang, Yongxiao Li, Wanting Xu, Yuan Mo, Xinpei Wang, Daiyun Xu, Shengbin Li, Zhe Wang, Meiying Wu, Junqing Wang   +12 more
doaj   +1 more source

Recent Advances in Tetrahedral Framework Nucleic Acids for Multimodal Synergistic Cancer Therapy

Aggregate, Volume 7, Issue 4, April 2026.
This review summarizes recent advances in tFNA‐based multimodal cancer therapy, including structural features, delivery strategies, and therapeutic regimens addressing key challenges in cancer treatment. We outline design principles, address translational hurdles, and highlight intelligent response and immune regulation as promising directions to ...
Zishan Huang, Zhitong Chen, Zhiyu Zhang, Hong Sun, Xujuan Li, Zhaogang Sun, Hongqian Chu, Wenjing Liu   +7 more
wiley   +1 more source

3D-Printed Artificial Microfish [PDF]

, 2015
Hydrogel microfish featuring biomimetic structures, locomotive capabilities, and functionalized nanoparticles are engineered using a rapid 3D printing platform: microscale continuous ­optical printing (μCOP).
Chen, Shaochen, Chung, Peter H., Dong, Renfeng, Gao, Wei, Leong, Yew J., Li, Jinxing, Qu, Xin, Rozen, Isaac, Wang, Joseph, Wu, Zhiguang, Zhu, Wei   +10 more
core   +1 more source

Distinct Host Gene Expression Patterns Induced by Covert Deformed Wing Virus Infections in Honeybees (Apis mellifera)

Archives of Insect Biochemistry and Physiology, Volume 121, Issue 4, April 2026.
A transcriptome study was established in Ordu, Türkiye using genetically related A. mellifera anatoliaca colonies founded by super‐sister queens. Nurse bees were collected and high‐quality RNA was sequenced on an Illumina NovaSeq 6000 platform, and analyzed on the Sabancı University HPC cluster (1).
Ali Sinan Kara, Samet Okuyan, Hatice Nur Kaynak, Serap Sakarya, Zeynep Ebrar Yavuz, Salim Aktürk, Gökhan Akdeniz, Aydin Turkec, Stuart J. Lucas   +8 more
wiley   +1 more source

SiO2–alginate–melittin nano-conjugates suppress the proliferation of ovarian cancer cells: a controlled release approach leveraging alginate lyase

Cancer Nanotechnology
Background Ovarian cancer treatment is challenged by resistance and off-target effects. Melittin shows promise against cancer but is limited by its instability and harmful cellular interactions. Our study introduces SiO2–alginate–melittin nano-conjugates
Lihui Si, Shuli Yang, Ruixin Lin, Shiyu Gu, Chuhan Yan, Jia Yan   +5 more
doaj   +1 more source

Novel Molecules for Intra-Oral Delivery of Antimicrobials to Prevent and Treat Oral Infectious Diseases [PDF]

, 2008
New molecules were designed for efficient intra-oral delivery of antimicrobials to prevent and treat oral infection. The salivary statherin fragment, which has high affinity for the tooth enamel, was used as a carrier peptide. This was linked through the
Dentino, Andrew R., Raj, Periathamby A., Rajkumar, Latha   +2 more
core   +1 more source

A review of selected bee products as potential anti-bacterial, anti-fungal, and anti-viral agents [PDF]

, 2016
Antimicrobial resistance (AMR) is one of the greatest medical challenges the world faces. It was estimated recently that by 2050, AMR will account for 10 million extra deaths annually with additional economic costs in the region of $100 trillion.
Brown, Helen Louise, Cooper, Rose, Jenkins, Rowena, Roberts, Aled Edward Lloyd   +3 more
core   +1 more source

Multiple Membrane Interactions and Versatile Vesicle Deformations Elicited by Melittin

Toxins, 2013
Melittin induces various reactions in membranes and has been widely studied as a model for membrane-interacting peptide; however, the mechanism whereby melittin elicits its effects remains unclear. Here, we observed melittin-induced changes in individual
Kingo Takiguchi, Michio Homma, Yasunori Yokoyama, Yohko Tanaka-Takiguchi, Tomoyoshi Takahashi, Fumimasa Nomura   +5 more
doaj   +1 more source