Results 81 to 90 of about 7,897 (182)

Multi‐Omics Analyses Elucidate the Venom Components of the Wasp Vespa mandarinia

Ecology and Evolution, Volume 16, Issue 6, June 2026.
The wasp Vespa mandarinia was widely reared in Yunnan province. The venom was responsible for their aggressive behavior. Tweety proteases, hyaluronidase, venom dipeptidyl peptidase 4, and phospholipase A1 and A2 isozyme were identified. In addition, organic heterocyclic compounds, organic acids, and derivatives were found.
Yuan‐Chong Shi, Hai‐Feng Mo, Shu‐Hui Yu, Xiao‐Yun Niu, Pu Yang   +4 more
wiley   +1 more source

Targeting Middle East Respiratory Syndrome Coronavirus Spike Fusion Machinery With Antiviral Peptides: In Silico Exploration of the Heptad Repeat 2 Domain

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Griffithsin, Brevinin‐2, and CCL20 were identified as potent MERS‐CoV fusion inhibitor candidates targeting the HR2 domain through integrated molecular docking, MD simulations, and MM/PBSA analyses. These peptides demonstrated superior binding stability and favorable safety profiles compared to the standard inhibitor, supporting their potential as ...
Nasser Alotaiq, Doni Dermawan, Samir Chtita   +2 more
wiley   +1 more source

The membrane effects of melittin on gastric and colorectal cancer.

PLoS ONE, 2019
The cytotoxic effects of melittin, a bee-venom peptide, have been widely studied towards cancer cells. Typically, these studies have examined the effect of melittin over extended-time courses (6-24 hours), meaning that immediate cellular interactions ...
Caroline Soliman, Sarah Eastwood, Vi Khanh Truong, Paul A Ramsland, Aaron Elbourne   +4 more
doaj   +1 more source

Effects of Melittin Treatment in Cholangitis and Biliary Fibrosis in a Model of Xenobiotic-Induced Cholestasis in Mice

Toxins, 2015
Cholangiopathy is a chronic immune-mediated disease of the liver, which is characterized by cholangitis, ductular reaction and biliary-type hepatic fibrosis. There is no proven medical therapy that changes the course of the disease.
Kyung-Hyun Kim, Hyun-Jung Sung, Woo-Ram Lee, Hyun-Jin An, Jung-Yeon Kim, Sok Cheon Pak, Sang-Mi Han, Kwan-Kyu Park   +7 more
doaj   +1 more source

The Novel Fusion Protein Melittin‐MIL‐2 Exhibits Strong Antitumor Immune Effect in Lung Adenocarcinoma Cell A549

The Clinical Respiratory Journal
In previous studies, we developed a novel fusion protein named “melittin‐MIL‐2” which exhibited more anti‐tumor activity. However, it remains unclear whether melittin‐MIL‐2 possesses antitumor immune effect on lung adenocarcinoma.
Weize Gao, Wenshuai Li, Zhan Wang, Yongxin Li, Mingjun Liu   +4 more
doaj   +1 more source

Synthesis and Evaluation of Melittin-Modified Peptides for Antibacterial Activity

Toxins
Melittin, a naturally occurring antimicrobial peptide, demonstrates broad-spectrum activity, effectively suppressing and eliminating both Gram-positive and Gram-negative bacteria, including specific drug-resistant strains.
Xiangxiang Xu, Hongyi Fu, Weihui Wu, Liang Zong, Dan Li, Bo Zhuang, Yelin Qi, Xiuli Qi, Ting Liang   +8 more
doaj   +1 more source

Functional analysis of the Escherichia coli mrdA gene in melittin resistance

Frontiers in Microbiology
ObjectiveThe aim of this study is to examine the functional role and resistance mechanisms of the Escherichia coli (E. coli) peptidoglycan transpeptidase gene, mrdA, in resistance to melittin.MethodsThe resistance of E.
Chong-Yi Zhao, Xiao Li, Ting Zhao, Ying Liu, Xue-Shan Xia, Xiao-Mei Wu   +5 more
doaj   +1 more source

Isolation of Melittin from Iranian Honey Bee Venom and Investigation of Its Effect on Proliferation of Cervical Cancer- HeLa Cell Line

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2013
Introduction: Cervical cancer is the second prevalent cancer in developing countries and the sixth prevalent cancer in USA. Since conventional treatment methods are associated with detrimental side effects, searching for new drugs using natural ...
K Pooshang Bagheri, A Mahmoodzadeh, H Zarinnahad, M Mahdavi, D Shahbazzadeh, A Moradi   +5 more
doaj  

Effects of 1-butyl-3-methyl-imidazolium acetate on the solution behavior of melittin: A molecular dynamics study

Journal of Ionic Liquids
Ionic liquids posses efficiency as solvents, co-solvents or agents for applications involving biomolecules. Due to the increasing interest in systems containing proteins and ionic liquids, we hereby present results from molecular dynamics simulations on ...
Jessé Neumann, Hubert K. Stassen
doaj   +1 more source

Melittin alleviates sepsis-induced acute kidney injury by promoting GPX4 expression to inhibit ferroptosis

Redox Report
Objectives: Melittin, the main component of bee venom, is a natural anti-inflammatory substance, in addition to its ability to fight cancer, antiviral, and useful in diabetes treatment.
Hongyan Zan, Jizheng Liu, Meixia Yang, Honghui Zhao, Chunyan Gao, Yunyan Dai, Zhiming Wang, Hongxuan Liu, Yunfei Zhang   +8 more
doaj   +1 more source