Protective Effects of Apamin on Acetaminophen-Induced Hepatotoxicity in Mice
Current Issues in Molecular Biology, 2023 Acetaminophen (APAP) overdose can cause severe liver damage, but therapeutic options are limited. Apamin is a natural peptide present in bee venom and has antioxidant and anti-inflammatory properties.
Gyunmoo Kim +2 more
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Apamin Structure and Pharmacology Revisited
Frontiers in Pharmacology, 2022 Apamin is often cited as one of the few substances selectively acting on small-conductance Ca2+-activated potassium channels (KCa2). However, published pharmacological and structural data remain controversial.
Ernesto Lopes Pinheiro-Junior +2 more
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Therapeutic Effects of Apamin as a Bee Venom Component for Non-Neoplastic Disease
Toxins, 2020 Bee venom is a natural toxin produced by honeybees and plays an important role in defending bee colonies. Bee venom has several kinds of peptides, including melittin, apamin, adolapamine, and mast cell degranulation peptides. Apamin accounts for about 2%&
Kwan-Kyu Park, Sang Mi Han, Hyemin Gu
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Melittin- and Apamin-Standardized Bee Venom: UHPLC-ESI-MS Characterization, Antibacterial Activity, and Apoptosis Induction in Human Keratinocytes [PDF]
MoleculesBee venom (BV) is valued therapeutically mainly for its peptides, melittin and apamin. This study determined the dose-dependent biological activity of bee venom standardized to its melittin and apamin content by UHPLC-ESI-MS, as well as that of its ...
Anna Kurek-Górecka +9 more
doaj +2 more sources
Molecules, 2020 Sepsis is the major cause of acute kidney injury (AKI) in severely ill patients, but only limited therapeutic options are available. During sepsis, lipopolysaccharide (LPS), an endotoxin derived from bacteria, activates signaling cascades involved in ...
Jung-Yeon Kim +2 more
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Bilobalide increases SKCa current via 5-HT2BR-PLC–PKC pathway, causing hyperpolarization and enhanced EET production in human coronary artery endothelial cells [PDF]
BMC Complementary Medicine and TherapiesBackground Ginkgo biloba extract and its active component bilobalide induce endothelium-dependent vasodilation in coronary and other vascular beds. This effect is associated with increased Ca2+-activated K+ channel activity in endothelial cells. We aimed
Katesirin Ruamyod +4 more
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Toxins, 2015 While knowledge of the composition and mode of action of bee and wasp venoms dates back 50 years, the therapeutic value of these toxins remains relatively unexploded.
Ernest Giralt i Lledó
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Investigating the immunomodulatory effects of honeybee venom peptide apamin in Drosophila platforms [PDF]
Infection and ImmunityApamin, an 18-amino-acid honeybee venom peptide, although traditionally recognized for its neurotoxic effects, demonstrates potent antimicrobial properties in our research when genetically expressed in Drosophila.
Yanan Wei +8 more
doaj +2 more sources
Structural mechanisms for inhibition and activation of human small-conductance Ca2+-activated potassium channel SK2 [PDF]
Nature CommunicationsThe small-conductance calcium-activated potassium (SK1-3 or KCa2) channels regulate the intrinsic excitability and firing frequency of excitable cells.
Bao Ma +9 more
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Mechanism of SK2 channel gating and its modulation by the bee toxin apamin and small molecules [PDF]
eLifeSmall-conductance calcium-activated potassium channel 2 (SK2) serves a variety of biological functions by coupling intracellular calcium dynamics with membrane potential.
Samantha J Cassell +9 more
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