Apamin structure and pharmacology revisited [PDF]
Frontiers in Pharmacology, 2022 Apamin is often cited as one of the few substances selectively acting on small-conductance Ca2+-activated potassium channels (KCa2). However, published pharmacological and structural data remain controversial.
Alexey I Kuzmenkov +2 more
exaly +8 more sources
Protective Effects of Apamin on Acetaminophen-Induced Hepatotoxicity in Mice
Current Issues in Molecular Biology, 2023 Acetaminophen (APAP) overdose can cause severe liver damage, but therapeutic options are limited. Apamin is a natural peptide present in bee venom and has antioxidant and anti-inflammatory properties.
Hyo-Jeong Jang +2 more
exaly +4 more sources
Apamin Enhances Neurite Outgrowth and Regeneration after Laceration Injury in Cortical Neurons
Toxins, 2021 Apamin is a minor component of bee venom and is a polypeptide with 18 amino acid residues. Although apamin is considered a neurotoxic compound that blocks the potassium channel, its neuroprotective effects on neurons have been recently reported. However,
Hyunseong Kim +2 more
exaly +4 more sources
Therapeutic Effects of Apamin as a Bee Venom Component for Non-Neoplastic Disease
Toxins, 2020 Bee venom is a natural toxin produced by honeybees and plays an important role in defending bee colonies. Bee venom has several kinds of peptides, including melittin, apamin, adolapamine, and mast cell degranulation peptides. Apamin accounts for about 2%&
Hyemin Gu, Sang-Mi Han, Kwan-Kyu Park
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Molecules, 2020 Sepsis is the major cause of acute kidney injury (AKI) in severely ill patients, but only limited therapeutic options are available. During sepsis, lipopolysaccharide (LPS), an endotoxin derived from bacteria, activates signaling cascades involved in ...
Jung-Yeon Kim +2 more
exaly +4 more sources
Investigating the immunomodulatory effects of honeybee venom peptide apamin in Drosophila platforms [PDF]
Infection and ImmunityApamin, an 18-amino-acid honeybee venom peptide, although traditionally recognized for its neurotoxic effects, demonstrates potent antimicrobial properties in our research when genetically expressed in Drosophila.
Yanan Wei +8 more
doaj +2 more sources
Small-conductance Ca<sup>2</sup>⁺-activated K⁺ channels in cardiac excitation-contraction coupling: Bridging mitochondria, sarcolemma and antiarrhythmic therapy. [PDF]
J PhysiolAbstract figure legend Mitochondrial SK channel enhancement reduces cardiac arrhythmia trigger. Spontaneous sarcoplasmic reticulum (SR) Ca2+ release via hyperactive RyR2s underlies an increased arrhythmia trigger, promoting early and delayed afterdepolarizations during stress. Hyperactive RyR2s causes rise in cytosolic [Ca2+] during diastole. Clearance
Terentyev D +7 more
europepmc +2 more sources
Selectively Blocking Small Conductance Ca2+-Activated K+ Channels Improves Cognition in Aged Mice [PDF]
BiologyAging is associated with decreased neuronal sensitivity and activity that creates deficits in cognitive processes, including learning, memory, motivation, general activity, and other behaviors. These effects are due in part to decreased intracellular Ca2+
Jessie Ong +2 more
doaj +2 more sources
Mechanism of SK2 channel gating and its modulation by the bee toxin apamin and small molecules [PDF]
eLifeSmall-conductance calcium-activated potassium channel 2 (SK2) serves a variety of biological functions by coupling intracellular calcium dynamics with membrane potential.
Samantha J Cassell +9 more
doaj +2 more sources
Toxins, 2015 While knowledge of the composition and mode of action of bee and wasp venoms dates back 50 years, the therapeutic value of these toxins remains relatively unexploded.
MIGUEL Moreno +2 more
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