Results 21 to 30 of about 5,766 (207)
Ginsenoside Re increases human coronary artery endothelial SKCa current and nitric oxide release via glucocorticoid receptor-PI3K-Akt/PKB pathway [PDF]
Journal of Ginseng ResearchBackground: Ginsenoside Re (Re) has been shown to activate small-conductance calcium-activated potassium (SKCa) current in human coronary artery endothelial cells (HCAECs).
Kitinat Rodthongdee +6 more
doaj +2 more sources
A proposal for the structure of apamin [PDF]
FEBS Letters, 1980 Apamin is an octadecapeptide neurotoxin present in bee venom. It acts both centrally and peripherally, binding specifically to a protein in rat forebrain with high affinity (Kd 10-l’ M) [l] and acting as a potent noncompetitive inhibitor of a-adrenergic and purinergic agonists [2].
Hider, R.C., Ragnarsson, U.
openaire +2 more sources
Apamin-Conjugated Alendronate Sodium Nanocomplex for Management of Pancreatic Cancer
Pharmaceuticals, 2021 Pancreatic cancer has a low survival rate and has limited therapeutic options due to the peculiarity of the tumor tissue. Cancer nanotechnology provides several opportunities to resolve such difficulties as a result of the high surface-to-volume ratio of
Nabil A. Alhakamy +3 more
doaj +1 more source
The relationship between functional inhibition and binding for K(Ca)2 channel blockers. [PDF]
PLoS ONE, 2013 Small conductance calcium-activated potassium channels (KCa2.1,2.2,2.3) are blocked with high affinity by both peptide toxins (e.g. apamin) and small molecule blockers (e.g. UCL 1848). In electrophysiological experiments, apamin shows subtype selectivity
David Charles Hammond Benton +2 more
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COLCHICINE ALTERS APAMIN RECEPTORS, ELECTRICAL-ACTIVITY, AND SKELETAL-MUSCLE RELAXATION [PDF]
, 1993 A low conductance calcium-activated K+ channel is thought to regulate the rate of firing of several excitable cells. In skeletal muscle the expression of this channel is under nerve control. Previously, we reported that axonal flow blockade of rat nerves,
BEHRENS, MI, VERGARA, C, RAMIREZ, B
core +2 more sources
Pharmaceuticals, 2022 Sinus pacemaking is based on tight cooperation of intracellular Ca2+ handling and surface membrane ion channels. An important player of this synergistic crosstalk could be the small-conductance Ca2+-activated K+-channel (ISK) that could contribute to the
Gergő Bitay +6 more
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Allosteric Block of KCa2 Channels by Apamin [PDF]
Journal of Biological Chemistry, 2010 Activation of small conductance calcium-activated potassium (K(Ca)2) channels can regulate neuronal firing and synaptic plasticity. They are characterized by their high sensitivity to the bee venom toxin apamin, but the mechanism of block is not understood.
Lamy, Cédric +6 more
openaire +2 more sources
Inhibition of Small-Conductance, Ca2+-Activated K+ Current by Ondansetron
Frontiers in Pharmacology, 2021 Background: Small-conductance Ca2+-activated K+ channels (SK channels) have been proposed as antiarrhythmic targets for the treatment of atrial fibrillation.
Shuai Guo +4 more
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King Khalid University Journal of Health Sciences, 2023 Epithelial–mesenchymal transition (EMT) causes polarized and cohesive epithelial cells to become motile and join the extracellular matrix (ECM). Embryonic development, wound healing, and tissue repair need it.
Abdullah Alqarni
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Metabolites, 2020 Red blood cells (RBCs) are the most abundant cells in the human blood that have been extensively studied under morphology, ultrastructure, biochemical and molecular functions.
Agata Światły-Błaszkiewicz +7 more
doaj +1 more source