Results 21 to 30 of about 6,599 (204)

Human Foetal Neuroblasts Exhibit BK Channel-Dependent Membrane Voltage Oscillations upon Depolarization. [PDF]

Adv Sci (Weinh)
Primary cultures of neuroblasts isolated from the nucleus basalis of Meynert of 12‐weeks‐old human foetuses were prepared. Whole‐cell patch‐clamp recordings were performed by injecting a depolarizing stimulus current (+500 pA; 500 ms), and the membrane voltage recorded; this stimulus current evoked periodic‐like oscillations in membrane voltage ...
Coppi E, Cherchi F, Venturini M, Tommasi F, Gonzi S, Capacci C, Guarnieri G, Gallina P, Morelli A, Pugliese AM.   +9 more
europepmc   +2 more sources

Ginsenoside Re increases human coronary artery endothelial SKCa current and nitric oxide release via glucocorticoid receptor-PI3K-Akt/PKB pathway [PDF]

Journal of Ginseng Research
Background: Ginsenoside Re (Re) has been shown to activate small-conductance calcium-activated potassium (SKCa) current in human coronary artery endothelial cells (HCAECs).
Kitinat Rodthongdee, Wattana B. Watanapa, Katesirin Ruamyod, Namoiy Semprasert, Pimchanok Nambundit, Suwattanee Kooptiwut, Luecha Boontaveekul   +6 more
doaj   +2 more sources

Colchicine alters apamin receptors, electrical activity, and skeletal muscle relaxation [PDF]

, 1993
A low conductance calcium‐activated K+ channel is thought to regulate the rate of firing of several excitable cells. In skeletal muscle the expression of this channel is under nerve control. Previously, we reported that axonal flow blockade of rat nerves,
Behrens Pellegrino, María Isabel, Ramirez, Beatriz, Vergara Montecinos, Cecilia   +2 more
core   +2 more sources

Apamin-Conjugated Alendronate Sodium Nanocomplex for Management of Pancreatic Cancer

Pharmaceuticals, 2021
Pancreatic cancer has a low survival rate and has limited therapeutic options due to the peculiarity of the tumor tissue. Cancer nanotechnology provides several opportunities to resolve such difficulties as a result of the high surface-to-volume ratio of
Nabil A. Alhakamy, Osama A. A. Ahmed, Usama A. Fahmy, Shadab Md   +3 more
doaj   +1 more source

A proposal for the structure of apamin [PDF]

FEBS Letters, 1980
Apamin is an octadecapeptide neurotoxin present in bee venom. It acts both centrally and peripherally, binding specifically to a protein in rat forebrain with high affinity (Kd 10-l’ M) [l] and acting as a potent noncompetitive inhibitor of a-adrenergic and purinergic agonists [2].
Hider, R.C., Ragnarsson, U.
openaire   +2 more sources

The relationship between functional inhibition and binding for K(Ca)2 channel blockers. [PDF]

PLoS ONE, 2013
Small conductance calcium-activated potassium channels (KCa2.1,2.2,2.3) are blocked with high affinity by both peptide toxins (e.g. apamin) and small molecule blockers (e.g. UCL 1848). In electrophysiological experiments, apamin shows subtype selectivity
David Charles Hammond Benton, Monique Garbarg, Guy William John Moss   +2 more
doaj   +1 more source

EDNRB-dependent endothelin signaling reduces proliferation and promotes proneural-to-mesenchymal transition in gliomas. [PDF]

Mol Oncol
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Pineau D, Garcia L, Arnold H, Hanžek A, Arrieta M, Gauthier LR, Granotier-Beckers C, Boussin FD, Herbet A, Hautière M, Asei-Ceschino V, Jacques C, Brard L, Harnois T, Coronas V, Constantin B, Chatelier A, Chemin J, Urbach S, Seveno M, Hideg S, Ripoll C, Aguilar-Cázarez K, Zheng M, Huang GH, Lv SQ, Zhang L, Rondard P, Prezeau L, Pin JP, Duffau H, Bauchet L, Rigau V, Denat F, Truillet C, Boquet D, Hugnot JP.   +36 more
europepmc   +2 more sources

The Inhibition of the Small-Conductance Ca²⁺-Activated Potassium Channels Decreases the Sinus Node Pacemaking during Beta-Adrenergic Activation

Pharmaceuticals, 2022
Sinus pacemaking is based on tight cooperation of intracellular Ca2+ handling and surface membrane ion channels. An important player of this synergistic crosstalk could be the small-conductance Ca2+-activated K+-channel (ISK) that could contribute to the
Gergő Bitay, Noémi Tóth, Szilvia Déri, Jozefina Szlovák, Zsófia Kohajda, András Varró, Norbert Nagy   +6 more
doaj   +1 more source

Inhibition of Small-Conductance, Ca2+-Activated K+ Current by Ondansetron

Frontiers in Pharmacology, 2021
Background: Small-conductance Ca2+-activated K+ channels (SK channels) have been proposed as antiarrhythmic targets for the treatment of atrial fibrillation.
Shuai Guo, Zhenhui Chen, Peng-Sheng Chen, Michael Rubart, Michael Rubart   +4 more
doaj   +1 more source

Allosteric Block of KCa2 Channels by Apamin [PDF]

Journal of Biological Chemistry, 2010
Activation of small conductance calcium-activated potassium (K(Ca)2) channels can regulate neuronal firing and synaptic plasticity. They are characterized by their high sensitivity to the bee venom toxin apamin, but the mechanism of block is not understood.
Lamy, Cédric, Goodchild, Samuel J, Weatherall, Kate L, Jane, David E, Liégeois, Jean-François, Seutin, Vincent, Marrion, Neil V   +6 more
openaire   +2 more sources