The conformation of apamin [PDF]
FEBS Letters, 1986 Energy minimisation techniques are used as a tool to distinguish between different proposed models for the structure of the bee venom polypeptide apamin. The influence of electrostatic interactions on the resultant energies is noted. The model of Hider and Ragnarsson [(1980) FEBS Lett. 111, 189‐193] is found to be of consistently low energy.
Freeman, C. M. +3 more
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Toxins, 2017 Melittin and apamin are the main components of bee venom and they have been known to have anti-inflammatory and anti-fibrotic properties. The aim of this study was to evaluate the effect of melittin and apamin on airborne fungi-induced chemical mediator ...
Seung-Heon Shin +3 more
doaj +2 more sources
Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents. [PDF]
PLoS ONE, 2014 BackgroundApamin is commonly used as a small-conductance Ca2+-activated K+ (SK) current inhibitor. However, the specificity of apamin in cardiac tissues remains unclear.ObjectiveTo test the hypothesis that apamin does not inhibit any major cardiac ion ...
Chih-Chieh Yu +3 more
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Antimicrobial and antibiofilm effects of melittin and apamin bee venoms from apis mellifera l. on eskape pathogens and cytotoxic effects on l929 fibroblast cells [PDF]
Kafkas Universitesi Veteriner Fakültesi DergisiPublic health is facing a worldwide challenge due to the emergence of multiple antibiotic resistance in ESKAPE (Enterococcus faecalis, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Escherichia coli ...
Elif AYDIN +3 more
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Receptor‐mediated endocytosis of apamin by liver cells [PDF]
European Journal of Biochemistry, 1987 The binding and uptake of the bee venom toxin apamin, by guinea‐pig and rat liver were studied.Guinea‐pig liver plasma membranes contain inhibitable, high‐affinity binding sites for [125I]monoiodoapamin: Kd= 12.6±0.8 pM (SE); Bmax= 4.2±0.2 fmol/mg protein.
P N, Strong, W H, Evans
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Bee venom and its component apamin as neuroprotective agents in a Parkinson disease mouse model. [PDF]
PLoS ONE, 2013 Bee venom has recently been suggested to possess beneficial effects in the treatment of Parkinson disease (PD). For instance, it has been observed that bilateral acupoint stimulation of lower hind limbs with bee venom was protective in the acute 1-methyl-
Daniel Alvarez-Fischer +9 more
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Pravastatin Corrects Endothelial Dysfunction in Ex Vivo Uterine Radial Arteries in Preeclampsia. [PDF]
Acta Physiol (Oxf)ABSTRACT Aim Endothelium‐dependent relaxation in isolated uterine radial arteries from normotensive (NT) and preeclamptic (PE) pregnancies, and the acute effects of pravastatin in the latter vessels were assessed. Pravastatin is hypothesized to alleviate endothelial dysfunction in PE via modulating aspects of NO and endothelium‐derived ...
Luque NM +11 more
europepmc +2 more sources
Structural mechanisms for inhibition and activation of human small-conductance Ca2+-activated potassium channel SK2 [PDF]
Nature CommunicationsThe small-conductance calcium-activated potassium (SK1-3 or KCa2) channels regulate the intrinsic excitability and firing frequency of excitable cells.
Bao Ma +9 more
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Amiodarone inhibits apamin-sensitive potassium currents. [PDF]
PLoS ONE, 2013 Apamin sensitive potassium current (I KAS), carried by the type 2 small conductance Ca(2+)-activated potassium (SK2) channels, plays an important role in post-shock action potential duration (APD) shortening and recurrent spontaneous ventricular ...
Isik Turker +7 more
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Animal Venoms as Peptide Libraries for the Discovery of Antiglioblastoma Agents. [PDF]
Biochem Res IntGlioblastoma is one of the most aggressive and widely recognized types of brain tumors, characterized by significant cellular and molecular diversity and an inherently aggressive nature. The treatment remains highly challenging, with limited effectiveness and persistently low survival rates.
Santiago LR +5 more
europepmc +2 more sources