Apamin Enhances Neurite Outgrowth and Regeneration after Laceration Injury in Cortical Neurons
Toxins, 2021 Apamin is a minor component of bee venom and is a polypeptide with 18 amino acid residues. Although apamin is considered a neurotoxic compound that blocks the potassium channel, its neuroprotective effects on neurons have been recently reported. However,
Hyunseong Kim +4 more
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The conformation of apamin [PDF]
FEBS Letters, 1986 Energy minimisation techniques are used as a tool to distinguish between different proposed models for the structure of the bee venom polypeptide apamin. The influence of electrostatic interactions on the resultant energies is noted. The model of Hider and Ragnarsson [(1980) FEBS Lett. 111, 189‐193] is found to be of consistently low energy.
Freeman, C. M. +3 more
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Bee venom and its component apamin as neuroprotective agents in a Parkinson disease mouse model. [PDF]
PLoS ONE, 2013 Bee venom has recently been suggested to possess beneficial effects in the treatment of Parkinson disease (PD). For instance, it has been observed that bilateral acupoint stimulation of lower hind limbs with bee venom was protective in the acute 1-methyl-
Daniel Alvarez-Fischer +9 more
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Toxins, 2017 Melittin and apamin are the main components of bee venom and they have been known to have anti-inflammatory and anti-fibrotic properties. The aim of this study was to evaluate the effect of melittin and apamin on airborne fungi-induced chemical mediator ...
Seung-Heon Shin +3 more
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Antimicrobial and antibiofilm effects of melittin and apamin bee venoms from apis mellifera l. on eskape pathogens and cytotoxic effects on l929 fibroblast cells [PDF]
Kafkas Universitesi Veteriner Fakültesi DergisiPublic health is facing a worldwide challenge due to the emergence of multiple antibiotic resistance in ESKAPE (Enterococcus faecalis, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Escherichia coli ...
Elif AYDIN +3 more
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Novel Nanoconjugate of Apamin and Ceftriaxone for Management of Diabetic Wounds
Life, 2022 Diabetic hyperglycemia delays wound healing, leading to serious consequences. Topical antibiotics can reduce the risk of a wound infection during healing; nevertheless, the microbial fight against antibiotics brings about public health challenges.
Abdullah A. Alamoudi +9 more
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Receptor‐mediated endocytosis of apamin by liver cells [PDF]
European Journal of Biochemistry, 1987 The binding and uptake of the bee venom toxin apamin, by guinea‐pig and rat liver were studied.Guinea‐pig liver plasma membranes contain inhibitable, high‐affinity binding sites for [125I]monoiodoapamin: Kd= 12.6±0.8 pM (SE); Bmax= 4.2±0.2 fmol/mg protein.
P N, Strong, W H, Evans
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Apamin inhibits NO-induced relaxation of the spontaneous contractile activity of the myometrium from non-pregnant women [PDF]
Reproductive Biology and Endocrinology, 2003 There is now considerable evidence for the involvement of K+ channels in nitric oxide (NO) induced relaxation of smooth muscles including the myometrium.
Kleszczewski Tomasz +4 more
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Amiodarone inhibits apamin-sensitive potassium currents. [PDF]
PLoS ONE, 2013 Apamin sensitive potassium current (I KAS), carried by the type 2 small conductance Ca(2+)-activated potassium (SK2) channels, plays an important role in post-shock action potential duration (APD) shortening and recurrent spontaneous ventricular ...
Isik Turker +7 more
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Voltage-gated calcium channel activity of gonadotropin-releasing hormone (GnRH) neurons is altered by age and by prenatal androgen exposure in female mice. [PDF]
J NeuroendocrinolAbstract Polyendocrine metabolic ovarian syndrome (PMOS), a common cause of infertility, is marked by persistently high luteinizing hormone (LH) pulse frequency, presumably driven by high‐frequency GnRH pulses. Prenatally androgenized (PNA) mice mimic neuroendocrine PMOS symptoms including high LH‐pulse frequency.
Chen X, Jaime J, DeFazio RA, Moenter SM.
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