Results 41 to 50 of about 6,599 (204)
Factors Affecting Quality of Honey Bee Venom
Journal of Apicultural Science, 2022 Honeybee venom (HBV) is an important product of beehives, and its benefits for health have been rediscovered by modern medicine. Since HBV has the potential to treat some diseases, its quality and production conditions require a detailed investigation ...
Kekeçoğlu Meral +4 more
doaj +1 more source
Development of Relaxin-3 Agonists and Antagonists Based on Grafted Disulfide-Stabilized Scaffolds
Frontiers in Chemistry, 2020 Relaxin-3 is a neuropeptide with important roles in metabolism, arousal, learning and memory. Its cognate receptor is the relaxin family peptide-3 (RXFP3) receptor.
Han Siean Lee +7 more
doaj +1 more source
Apamin modulates ventricular repolarization during HF.
, 2014 Representative action potential of a 1 month (A) HF and 4 month HF(B) ventricular cell before and after apamin superfusion. C. Summary data of APD50 in control,1 month and 4 month HF before and after apamin treatment.
Ingrid M. Bonilla (474103) +14 more
core +1 more source
Small‐Conductance Calcium‐Activated Potassium Current in Normal Rabbit Cardiac Purkinje Cells
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 BackgroundPurkinje cells (PCs) are important in cardiac arrhythmogenesis. Whether small‐conductance calcium‐activated potassium (SK) channels are present in PCs remains unclear. We tested the hypotheses that subtype 2 SK (SK2) channel proteins and apamin‐
Thomas A. Reher +13 more
doaj +1 more source
Toxins, 2020 Natural products represent important sources for the discovery and design of novel drugs. Bee venom and its isolated components have been intensively studied with respect to their potential to counteract or ameliorate diverse human diseases.
Andreas Aufschnaiter +6 more
doaj +1 more source
Identification of TREK channels in mouse intracardiac ganglion neurons
The Journal of Physiology, EarlyView.Abstract figure legend Role of TWIK‐related K+ (TREK) channels in intracardiac ganglion neurons. CD‐1 mice were used to establish primary cultures of intracardiac neurons for immunochemical characterization and patch‐clamp electrophysiology. Intracardiac neurons express functional TREK channels, which modulate neuronal excitability by regulating ...
Ana Campos‐Rios +9 more
wiley +1 more source
The relationship between apamin binding and channel block in KCa2 potassium channels. [PDF]
, 2013 Small conductance calcium-activated potassium channels (KCa2.1,2.2,2.3) are widely distributed throughout the body and are involved in diverse physiological processes including the regulation of neuronal firing and smooth muscle contraction.
Jenkinson, DH +3 more
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Apamin, a highly specific Ca2+ blocking agent in heart muscle
, 1985 Apamin, a bee venom polypeptide, was recently reported to block specifically the Ca2+-dependent K+ channels that are not blocked by tetraethylammonium chloride in muscle cells.
N. Sperelakis +3 more
core +1 more source
, 2014 (A) An observation experiment without apamin treatment showing time-dependent rundown, obtained with the pulse protocol shown in the inset with chromanol 293B at the end.
Chih-Chieh Yu (127641) +3 more
core +2 more sources
The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines. [PDF]
, 2000 The pharmacology of hSK1, a small conductance calcium-activated potassium channel, was studied in mammalian cell lines (HEK293 and COS-7). In these cell types, hSK1 forms an apamin-sensitive channel with an IC(50) for apamin of 8 nM in HEK293 cells and ...
Shah, M, Haylett, DG
core