Results 41 to 50 of about 5,766 (207)
Toxins, 2020 Natural products represent important sources for the discovery and design of novel drugs. Bee venom and its isolated components have been intensively studied with respect to their potential to counteract or ameliorate diverse human diseases.
Andreas Aufschnaiter +6 more
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Apamin modulates ventricular repolarization during HF.
, 2014 Representative action potential of a 1 month (A) HF and 4 month HF(B) ventricular cell before and after apamin superfusion. C. Summary data of APD50 in control,1 month and 4 month HF before and after apamin treatment.
Ingrid M. Bonilla (474103) +14 more
core +1 more source
Small‐Conductance Calcium‐Activated Potassium Current in Normal Rabbit Cardiac Purkinje Cells
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 BackgroundPurkinje cells (PCs) are important in cardiac arrhythmogenesis. Whether small‐conductance calcium‐activated potassium (SK) channels are present in PCs remains unclear. We tested the hypotheses that subtype 2 SK (SK2) channel proteins and apamin‐
Thomas A. Reher +13 more
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The effect of Xenin25 on spontaneous circular muscle contractions of rat distal colon in vitro
Physiological Reports, 2021 Xenin25 has a variety of physiological functions in the Gastrointestinal (GI) tract, including ion transport and motility. However, the motility responses in the colon induced by Xenin25 remain poorly understood.
Yuko Kuwahara +4 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Angiotensin II induces vascular inflammation, senescence, extracellular matrix (ECM) degradation and endothelial dysfunction, thus impairing SK+/IK+ channel function and reducing endothelial‐dependent hyperpolarisation (EDH). Metformin activates AMPK, increasing SK+/IK+ channel function and restoring vasorelaxation.
Soroush Mohammadi Jouabadi +10 more
wiley +1 more source
Neuroprotection, Volume 4, Issue 2, Page 169-177, June 2026.Experimental design and behavioral outcomes of bee venom treatment in a murine model of Parkinson's disease. Mice received an intrastriatal injection of 6‐OHDA into the right hemisphere to induce dopaminergic degeneration. Animals were subsequently treated with l‐DOPA/carbidopa, with or without bee venom (BV) administered intraperitoneally.
Silvia Josefina López‐Pérez +2 more
wiley +1 more source
Apamin, a highly specific Ca2+ blocking agent in heart muscle
, 1985 Apamin, a bee venom polypeptide, was recently reported to block specifically the Ca2+-dependent K+ channels that are not blocked by tetraethylammonium chloride in muscle cells.
N. Sperelakis +3 more
core +1 more source
Reproductive Biology and Endocrinology, 2003 There is now considerable evidence for the involvement of K+ channels in nitric oxide (NO) induced relaxation of smooth muscles including the myometrium.
Kleszczewski Tomasz +4 more
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Metaplastic effect of apamin on LTP and paired-pulse facilitation
, 2007 peer reviewedIn area CA1 of hippocampal slices, a single 1-sec train of 100-Hz stimulation generally triggers a short-lasting long-term potentiation (S-LTP) of 1-2 h. Here, we found that when such a train was applied 45 min after application of the small
Capron, B. +9 more
core +1 more source
An evaluation of the chemical content and microbiological contamination of Anatolian bee venom.
PLoS ONE, 2021 Bee venom is a natural substance produced by worker bees. The aim of this research paper is to determine the characteristics of Anatolian bee venom by evaluating its chemical content and microbiological properties.
Aslı Elif Tanuğur-Samanc +1 more
doaj +1 more source