Results 61 to 70 of about 6,599 (204)

AMPK‐mediated prevention of vascular dysfunction with metformin: Experimental and population‐based evidence

British Journal of Pharmacology, Volume 183, Issue 17, Page 5389-5406, September 2026.
Angiotensin II induces vascular inflammation, senescence, extracellular matrix (ECM) degradation and endothelial dysfunction, thus impairing SK+/IK+ channel function and reducing endothelial‐dependent hyperpolarisation (EDH). Metformin activates AMPK, increasing SK+/IK+ channel function and restoring vasorelaxation.
Soroush Mohammadi Jouabadi, Annika A. Jüttner, Annique Claringbould, Rene de Vries, Ingrid M. Garrelds, Usha Musterd‐Bhaggoe, Bruno H. Stricker, Maryam Kavousi, A. H. Jan Danser, Fariba Ahmadizar, Anton J. M. Roks   +10 more
wiley   +1 more source

Venom composition and pain-causing toxins of the Australian great carpenter bee Xylocopa aruana

Scientific Reports, 2022
Most species of bee are capable of delivering a defensive sting which is often painful. A solitary lifestyle is the ancestral state of bees and most extant species are solitary, but information on bee venoms comes predominantly from studies on eusocial ...
Naiqi Shi, Tibor G. Szanto, Jia He, Christina I. Schroeder, Andrew A. Walker, Jennifer R. Deuis, Irina Vetter, György Panyi, Glenn F. King, Samuel D. Robinson   +9 more
doaj   +1 more source

Therapeutic Potential and Mechanisms of Bee Venom Therapy: A Comprehensive Review of Apitoxin Applications and Safety Enhancement Strategies

Pharmaceuticals
Apitoxin therapy (BVT—bee venom therapy) is an emerging complementary treatment utilizing bee venom for various medical conditions. This review explores the potential and therapeutic mechanisms of bee venom, focusing on its chemical composition and the ...
Maksymilian Stela, Natalia Cichon, Aleksandra Spławska, Monika Szyposzynska, Michal Bijak   +4 more
doaj   +1 more source

The BK channel antagonist, apamin, blocked the facilitating action of EtOH on network bursts.

, 2013
A, sample recording of 3 neurons in the field of view, demonstrating that apamin at low concentration (40 nM) produces a transient facilitatory action on network activity.
Tatyana Bombela (485670), Tatiana Odegova (485671), Petr Zubov (485672), Menahem Segal (342544), Eduard Korkotian (201761)   +4 more
core   +1 more source

Apamin-sensitive SK channels are responsible for the main effect of NO on membrane potential.

, 2013
A: Representative recording of a B19 neuron before and after treatment with apamin (5 µM). Note that apamin application led to a sustained depolarization.
Stephen Estes (484038), Vincent Rehder (484040), Lei Ray Zhong (484037), Liana Artinian (484039)   +3 more
core   +1 more source

Small‐conductance Ca2⁺‐activated K⁺ channels in cardiac excitation–contraction coupling: Bridging mitochondria, sarcolemma and antiarrhythmic therapy

The Journal of Physiology, Volume 604, Issue 16, Page 6691-6703, 15 August 2026.
Abstract figure legend Mitochondrial SK channel enhancement reduces cardiac arrhythmia trigger. Spontaneous sarcoplasmic reticulum (SR) Ca2+ release via hyperactive RyR2s underlies an increased arrhythmia trigger, promoting early and delayed afterdepolarizations during stress. Hyperactive RyR2s causes rise in cytosolic [Ca2+] during diastole. Clearance
Dmitry Terentyev, Alexey V. Glukhov, Vladimir Bogdanov, Aleksei S. Averin, Roland Veress, Bum‐Rak Choi, Shanna Hamilton, Andriy E. Belevych   +7 more
wiley   +1 more source

Selectively Blocking Small Conductance Ca²⁺-Activated K⁺ Channels Improves Cognition in Aged Mice

Biology
Aging is associated with decreased neuronal sensitivity and activity that creates deficits in cognitive processes, including learning, memory, motivation, general activity, and other behaviors. These effects are due in part to decreased intracellular Ca2+
Jessie Ong, H. Craig Heller, Elsa Pittaras   +2 more
doaj   +1 more source

Bee venom enhances dopaminergic function and behavioral recovery in a murine model of Parkinson's disease

Neuroprotection, Volume 4, Issue 2, Page 169-177, June 2026.
Experimental design and behavioral outcomes of bee venom treatment in a murine model of Parkinson's disease. Mice received an intrastriatal injection of 6‐OHDA into the right hemisphere to induce dopaminergic degeneration. Animals were subsequently treated with l‐DOPA/carbidopa, with or without bee venom (BV) administered intraperitoneally.
Silvia Josefina López‐Pérez, Marco Antonio Noriega‐Ruiz, Alma Karen Lomeli‐Lepe   +2 more
wiley   +1 more source

Cells and ionic conductances contributing to spontaneous activity in bladder and urethral smooth muscle

The Journal of Physiology, Volume 604, Issue 9, Page 3611-3632, 1 May 2026.
Abstract figure legend Cells and conductances contributing to spontaneous activity in the lower urinary tract. Bladder and urethra exhibit spontaneous contractions at both cellular and tissue levels. Both detrusor and urethral smooth muscle cells display activity that is regular and rhythmic.
Bernard T. Drumm, Neha Gupta, Alexandru Mircea, Caoimhin S. Griffin   +3 more
wiley   +1 more source

Apamin Reduces the Late Afterhyperpolarization of Lamprey Spinal Neurons, with Little Effect on Fictive Swimming

, 1992
The role of the late afterhyperpolarization (late AHP) in the firing properties of lamprey spinal neurons was tested by bath application of apamin, a selective blocker of the sk calcium-dependent potassium current.
Meer, Daniel P., Buchanan, James T.
core   +1 more source