Results 81 to 90 of about 6,599 (204)

Participation of ATP in Nonadrenergic, Noncholinergic Relaxation of Longitudinal Muscle of Wistar Rat Jejunum

Journal of Pharmacological Sciences, 2005
A role of ATP in nonadrenergic, noncholinergic (NANC) relaxations was examined in the Wistar rat jejunum. Electrical field stimulation (EFS) induced NANC relaxation of longitudinal muscle of the jejunal segments in a frequency-dependent manner.
Kaori Waseda, Tadayoshi Takeuchi, Mayuko Ohta, Yutaka Okishio, Akikazu Fujita, Fumiaki Hata, Tadashi Takewaki   +6 more
doaj   +1 more source

Rapamycin prevents apamin-stimulated S6rp phosphorylation but not cellular activity in striatal CINs.

, 2013
(A) Cell-attached recording of a CIN in the presence of synaptic blockers picrotoxin (Pic, 100 µM), CNQX (10 µM) and DL-AP5 (AP5, 100 µM) showing changes in firing after application of rapamycin (dark gray) and apamin (black).
Billy C. Chieng (291650), Vincent Laurent (291651), Jesus Bertran-Gonzalez (266422), Bernard W. Balleine (291653), Emmanuel Valjent (73148)   +4 more
core   +1 more source

Quantification of 2-disulfide bonded isomers of apamin, a peptidic toxin, leads to the observation of a structural rearrangement

, 2021
Apamin (APA1) interacts strongly with SK channels and blocks corresponding SK currents. Apamin is an octadecapeptide with four cysteine residues assembled in two disulfide bridges.
Liégeois, Jean-François, Damblon, Christian, Vitello, Romain, Wanko Nembot, Alexis Marius, Hayen, Jean-Luc   +4 more
core   +1 more source

Apamin-Mediated Actively Targeted Drug Delivery for Treatment of Spinal Cord Injury: More Than Just a Concept

, 2016
Faced with the complex medical challenge presented by spinal cord injuries (SCI) and considering the lack of any available curative therapy, the development of a novel method of delivering existing drugs or candidate agents can be perceived to be as ...
Jin Wu (216487), Hong Jiang (79543), Qiuyan Bi (1757350), Yan Zhang (8098), Jianjun Li (139837), Qingsong Luo (1757347), Zhangbao Chen (396432), Chong Li (120471)   +7 more
core   +1 more source

Novel approaches for neuroprotection: Focus on neurodegenerative and ischemic central nervous system diseases

Neuroprotection, Volume 4, Issue 2, Page 95-98, June 2026.
Shen Li, Xunming Ji, Piotr Walczak, Johannes Boltze   +3 more
wiley   +1 more source

Apamin, a highly potent fetal L-type Ca2+ current blocker in single heart cells

, 1992
Apamin, a bee venom polypeptide, was reported to block the naturally occurring Ca2+ slow action potentials (APs) in cultured cell reaggregates from old chick hearts [Bkaily, G. et al. Am. J. Physiol. 248 (Heart Circ. Physiol.
D. Economos, D. Menard, A. Sculptoreanu, D. Jacques, G. Bkaily   +4 more
core   +1 more source

Cell-Cycle-Dependent Regulation of Ca2+-Activated K+ Channel in Jurkat T-Lymphocyte

Journal of Pharmacological Sciences, 2007
Small-conductance Ca2+-activated K+ (SK2) channel plays an important role in the activation of Jurkat T-lymphocytes by maintaining electrical gradients for the sustained Ca2+ influx. Apamin-sensitive K+ current was significantly decreased with cell-cycle
Takashi Morimoto, Susumu Ohya, Hidetoshi Hayashi, Kikuo Onozaki, Yuji Imaizumi   +4 more
doaj   +1 more source

Bicuculline methiodide potentiates NMDA-dependent burst firing in rat dopamine neurons by blocking apamin-sensitive Ca2+-activated K+ currents.

, 1997
peer reviewedApamin, a bee venom toxin which blocks a Ca2+-dependent K+ current, potentiates N-methyl-D-aspartate (NMDA)-induced burst firing in dopamine neurons. We now report that burst firing is also potentiated by an apamin-like effect of bicuculline
Seutin, Vincent, Steven W Johnson, Johnson, S. W., Vincent Seutin   +3 more
core   +1 more source

Activity-Dependent Plasticity of Spike Pauses in Cerebellar Purkinje Cells

Cell Reports, 2016
The plasticity of intrinsic excitability has been described in several types of neurons, but the significance of non-synaptic mechanisms in brain plasticity and learning remains elusive. Cerebellar Purkinje cells are inhibitory neurons that spontaneously
Giorgio Grasselli, Qionger He, Vivian Wan, John P. Adelman, Gen Ohtsuki, Christian Hansel   +5 more
doaj   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source