Results 101 to 110 of about 5,766 (207)

Bicuculline methiodide potentiates NMDA-dependent burst firing in rat dopamine neurons by blocking apamin-sensitive Ca2+-activated K+ currents.

, 1997
peer reviewedApamin, a bee venom toxin which blocks a Ca2+-dependent K+ current, potentiates N-methyl-D-aspartate (NMDA)-induced burst firing in dopamine neurons. We now report that burst firing is also potentiated by an apamin-like effect of bicuculline
Seutin, Vincent, Steven W Johnson, Johnson, S. W., Vincent Seutin   +3 more
core   +1 more source

Effects of different concentrations of apamin on the rundown course of I_Ks in transfected HEK 293 cells.

, 2014
(A) An observation experiment without apamin treatment showing time-dependent rundown, obtained with the pulse protocol shown in the inset with chromanol 293B at the end.
Chih-Chieh Yu (127641), Peng-Sheng Chen (438895), Tomohiko Ai (438896), James N. Weiss (228015)   +3 more
core   +1 more source

Quantification of 2-disulfide bonded isomers of apamin, a peptidic toxin, leads to the observation of a structural rearrangement

, 2021
Apamin (APA1) interacts strongly with SK channels and blocks corresponding SK currents. Apamin is an octadecapeptide with four cysteine residues assembled in two disulfide bridges.
Liégeois, Jean-François, Damblon, Christian, Vitello, Romain, Wanko Nembot, Alexis Marius, Hayen, Jean-Luc   +4 more
core  

Fast, But Not Slow, Effects of Olivocochlear Activation Are Resistant to Apamin

, 2001
Olivocochlear (OC) efferent suppression of auditory-nerve responses comprises a fast effect lasting tens of milliseconds and a slow effect building and decaying over tens of seconds.
M. Charles Liberman, William F. Sewell, M. Christian Brown, Naohiro Yoshida   +3 more
core   +1 more source

Polypeptide components of the apamin receptor associated with a calcium activated potassium channel

, 1990
Photoaflinity labeling of rat brain membraines with [125l]ANPAA-apamin incorporated radioactivity into polypeptides of 86 and 59 kDa and occasionally a more weakly labeled component of 45 kDa.
Leveque, Christian, Seagar, Michael, Beatrice Marqueze, Francois Couraud, Michael Seagar, Marqueze, Beatrice, Christian Leveque, Couraud, Francois   +7 more
core   +1 more source

Apamin boosts EPSPs in Ca_V2.3^-/- mice.

, 2015
(A) Time course of the normalized EPSP amplitude (mean ± s.e.m.) for baseline in control aCSF (Ctrl) and during wash-in of apamin (100 nM) as indicated above (n = 18) in CaV2.3-/- (blue symbols) and WT (black symbols) mice.
James Maylie (801465), Melissa H. Kelley (801462), Wendy W. Wu (801463), Kang Wang (415359), John P. Adelman (801464)   +4 more
core   +1 more source

Solubilization of the apamin receptor associated with a calcium- activated potassium channel from rat brain

, 1987
The apamin binding protein was solubilized from rat brain synaptic membranes using sodium cholate. Receptor yield and stability depended closely on the detergent/protein ratio.
F Couraud, B Marqueze, MJ Seagar
core   +1 more source

Apamin distinguishes two types of relaxation mediated by enteric nerves in the guinea-pig gastrointestinal tract

, 1986
Apamin distinguishes two types of relaxation mediated by enteric nerves in the guinea-pig gastrointestinal ...
CMS Humphreys (19465861), M Costa (7774499), John Furness (13070439)   +2 more
core  

Charybdotoxin and iberiotoxin but not apamin abolish the slow after-hyperpolarization in myenteric plexus neurons

, 1994
Charybdotoxin and iberiotoxin but not apamin abolish the slow after-hyperpolarization in myenteric plexus ...
DSH Stephenson (19465888), JC Bornstein (14474907), R Hendriks (13415667), John Furness (13070439), WAA Kunze (19187167)   +4 more
core  

A K_Ca 2.2/2.3 Opener Reverses ET-1-Induced NLRP3 Activation in Hypertensive Mice Corpora Cavernosa. [PDF]

Biomolecules
Sobrano Fais R, Comerma-Steffensen SG, Pinilla E, Matchkov VV, Tostes R, Silva Carneiro F, Simonsen U.   +6 more
europepmc   +1 more source