Results 91 to 100 of about 6,599 (204)

Effects of apamin on I_Ca and I_Na in rabbit cardiomyocytes.

, 2014
(A) The representative ICa tracings obtained by a pulse protocol shown in the inset before apamin (a), after apamin (b) and after nifedipine (c) at time points indicated by arrows a through c, respectively, in (B).
Chih-Chieh Yu (127641), Peng-Sheng Chen (438895), Tomohiko Ai (438896), James N. Weiss (228015)   +3 more
core   +1 more source

The Electrochemical and Statistical Evaluation of Isolation of Mellitin and Apamin from Honey Bee (Apis Mellifera) Venom

International Journal of Electrochemical Science, 2015
We present in this manuscript for the first time the electrochemical and statistical evaluation of FPLC isolation of mellitin and apamin from honey bee (Apis mellifera) venom. Venoms are extremely complex blends of diverse substances that target a myriad
Hoai Viet Nguyen, Zbynek Heger, Marketa Kominkova, Petr Michalek, Jaromir Gumulec, Roman Guran, Antonin Pridal, Carlos Fernandez, David Hynek, Vojtech Adam, Rene Kizek   +10 more
doaj   +1 more source

Bladder Contractility Is Mediated by Different K+ Channels in the Urothelium and Detrusor Smooth Muscle

Journal of Pharmacological Sciences, 2011
The roles played by K+ channels in the urothelium (UE) and detrusor smooth muscle (DSM) in regulating agonist-induced bladder contraction is not known at present. Thus, the effects in carbachol (CCh)-induced contraction in UE-intact (+UE) and UE-denuded (
Aneira Gracia Hidayat Santoso, Willmann Liang   +1 more
doaj   +1 more source

The disulphide bridges of apamin [PDF]

FEBS Letters, 1968
Callewaert, G.L., Shipolini, R., Vernon, C.A.   +2 more
openaire   +2 more sources

Apamin induces early afterdepolarizations and torsades de pointes ventricular arrhythmia from failing rabbit ventricles exhibiting secondary rises in intracellular calcium [PDF]

, 2013
BackgroundA secondary rise of intracellular Ca(2+) (Cai) and an upregulation of apamin-sensitive K(+) current (I(KAS)) are characteristic findings of failing ventricular myocytes. We hypothesize that apamin, a specific I(KAS) blocker, may induce torsades
Weiss, James N, Lin, Shien-Fong, Hsieh, Yu-Cheng, Chen, Peng-Sheng, Weiss, James N., Chang, Po-Cheng, Hsueh, Chia-Hsiang   +6 more
core   +1 more source

Potencial antiviral e virucida da melitina e apamina contra herpesvírus bovino tipo 1 e vírus da diarreia viral bovina

Pesquisa Veterinária Brasileira
RESUMO: A busca por alternativa aos fármacos sintéticos têm revelado descobertas no campo da farmacologia e, nesse sentido, melitina e apamina, dois constituintes do veneno de abelhas, foram descritas com várias ações farmacológicas.
Tony Picoli, Cristina M. Peter, Gilberto D. Vargas, Silvia O. Hübner, Marcelo de Lima, Geferson Fischer   +5 more
doaj   +1 more source

The Asparagine-Stabilized β-Turn of Apamin:  Contribution to Structural Stability from Dynamics Simulation and Amide Hydrogen Exchange Analysis^†

, 2016
Molecular dynamics simulations of bee venom apamin, and an analogue having an Asn to Ala substitution at residue 2 (apamin-N2A), were analyzed to explore the contribution of hydrogen bonds involving Asn2 to local (β-turn residues N2, C3, K4, A5) and ...
Nicole V. Lamble (2945463), Richard B. Sessions (87066), Christopher E. Dempsey (1308879), Stephen J. Campbell (2160841)   +3 more
core   +1 more source

Apamin suppresses the elevated network activity produced by exposure to low EtOH.

, 2013
A, the progress of the experiment; initially the culture was exposed to 0.25% and then to 0.5% EtOH, which produced a sustained rise in network activity. Further, the addition of 40 nM apamin caused a return to baseline network activity.
Tatyana Bombela (485670), Tatiana Odegova (485671), Petr Zubov (485672), Menahem Segal (342544), Eduard Korkotian (201761)   +4 more
core   +1 more source

Charybdotoxin and apamin block EDHF in rat mesenteric artery if selectively applied to the endothelium

, 1999
In rat mesenteric artery, endothelium-derived hyperpolarizing factor (EDHF) is blocked by a combination of apamin and charybdotoxin (ChTX). The site of action of these toxins has not been established.
Frances Plane, Joanne M. Doughty, Philip D. Langton   +2 more
core   +1 more source

The therapeutic potential of bee venom-derived Apamin and Melittin conjugates in cancer treatment: A systematic review

Pharmacological Research
The therapeutic potential of bee venom-derived peptides, particularly apamin and melittin, in cancer treatment has garnered significant attention as a promising avenue for advancing oncology.
Lucas Fornari Laurindo, Enzo Pereira de Lima, Lívia Fornari Laurindo, Victória Dogani Rodrigues, Eduardo Federighi Baisi Chagas, Ricardo de Alvares Goulart, Adriano Cressoni Araújo, Elen Landgraf Guiguer, Karina Torres Pomini, Rose Eli Grassi Rici, Durvanei Augusto Maria, Rosa Direito, Sandra Maria Barbalho   +12 more
doaj   +1 more source