Results 91 to 100 of about 5,766 (207)

Polypeptide constitution of receptors for apamin, a neurotoxin which blocks a class of Ca2+-activated K+ channels

, 1989
Affinity labelling experiments with different azido-125I-apamin derivatives were carried out to identify polypeptide components of the apamin-sensitive Ca2+-activated K+ channel in brain and pheochromocytoma cell membranes.
Michel Hugues, Lazdunski, Michel, Patrick Auguste, Michel Lazdunski, Hugues, Michel, Auguste, Patrick   +5 more
core   +1 more source

Effects of apamin on I_Ca and I_Na in rabbit cardiomyocytes.

, 2014
(A) The representative ICa tracings obtained by a pulse protocol shown in the inset before apamin (a), after apamin (b) and after nifedipine (c) at time points indicated by arrows a through c, respectively, in (B).
Chih-Chieh Yu (127641), Peng-Sheng Chen (438895), Tomohiko Ai (438896), James N. Weiss (228015)   +3 more
core   +1 more source

Bladder Contractility Is Mediated by Different K+ Channels in the Urothelium and Detrusor Smooth Muscle

Journal of Pharmacological Sciences, 2011
The roles played by K+ channels in the urothelium (UE) and detrusor smooth muscle (DSM) in regulating agonist-induced bladder contraction is not known at present. Thus, the effects in carbachol (CCh)-induced contraction in UE-intact (+UE) and UE-denuded (
Aneira Gracia Hidayat Santoso, Willmann Liang   +1 more
doaj   +1 more source

Potencial antiviral e virucida da melitina e apamina contra herpesvírus bovino tipo 1 e vírus da diarreia viral bovina

Pesquisa Veterinária Brasileira
RESUMO: A busca por alternativa aos fármacos sintéticos têm revelado descobertas no campo da farmacologia e, nesse sentido, melitina e apamina, dois constituintes do veneno de abelhas, foram descritas com várias ações farmacológicas.
Tony Picoli, Cristina M. Peter, Gilberto D. Vargas, Silvia O. Hübner, Marcelo de Lima, Geferson Fischer   +5 more
doaj   +1 more source

Effect of apamin on the responses to VIP, ATP and NANC neurone stimulation in the rat and cat gastric fundus

, 1991
1 The influence of apamin on non-adrenergic non-cholinergic (NANC) relaxation and on the effect of the putative transmitters VIP and ATP was examined in the rat and cat gastric fundus.
De Beurme, Freya A, Sas, Steven, Lefebvre, RomainGE338010003811850000-0003-2356-3714F3E60310-F0ED-11E1-A9DE-61C894A0A6B4, Lefebvre, Romain   +3 more
core   +1 more source

Boosting of EPSPs by SNX in the presence of apamin requires Ca_V2.3 R-type Ca²⁺ channels.

, 2015
(A) Time course of the normalized EPSP amplitude (mean ± s.e.m.) for baseline in apamin (100 nM) and during wash-in of SNX (300 nM) in the presence of apamin (n = 19).
James Maylie (801465), Melissa H. Kelley (801462), Wendy W. Wu (801463), Kang Wang (415359), John P. Adelman (801464)   +4 more
core   +1 more source

Effects of apamin and known K_Ca2 inhibitors on K_Ca2.2 current.

, 2013
A Typical current record from a HEK 293 cell transiently transfected with KCa2.2. In control solution (left panel) robust, time-independent currents are seen. Application of 10 nM apamin causes a very substantial reduction (right panel).
David Charles Hammond Benton (456734), Guy William John Moss (456736), Monique Garbarg (456735)   +2 more
core   +1 more source

The therapeutic potential of bee venom-derived Apamin and Melittin conjugates in cancer treatment: A systematic review

Pharmacological Research
The therapeutic potential of bee venom-derived peptides, particularly apamin and melittin, in cancer treatment has garnered significant attention as a promising avenue for advancing oncology.
Lucas Fornari Laurindo, Enzo Pereira de Lima, Lívia Fornari Laurindo, Victória Dogani Rodrigues, Eduardo Federighi Baisi Chagas, Ricardo de Alvares Goulart, Adriano Cressoni Araújo, Elen Landgraf Guiguer, Karina Torres Pomini, Rose Eli Grassi Rici, Durvanei Augusto Maria, Rosa Direito, Sandra Maria Barbalho   +12 more
doaj   +1 more source

The disulphide bridges of apamin [PDF]

FEBS Letters, 1968
Callewaert, G.L., Shipolini, R., Vernon, C.A.   +2 more
openaire   +2 more sources

Spontaneous Apamin-Sensitive Hyperpolarizations in Dopaminergic Neurons of Neonatal Rats

, 1998
peer reviewedSpontaneous apamin-sensitive hyperpolarizations in dopaminergic neurons of neonatal rats. J. Neurophysiol. 80: 3361-3364, 1998. Intracellular recordings from substantia nigra slices revealed the existence of spontaneous hyperpolarizations ...
Scuvée-Moreau, Jacqueline, Seutin, Vincent, Laurent Massotte, Jacqueline Scuvée-Moreau, Dresse, Albert, Albert Dresse, Vincent Seutin, Massotte, Laurent   +7 more
core   +1 more source