Results 71 to 80 of about 6,599 (204)

Pharmacology of airways and vessels in lung slices in situ: role of endogenous dilator hormones

Respiratory Research, 2006
Small airway and vessels play a critical role in chronic airway and pulmonary vascular diseases, but their pharmacology has not been well characterised.
Barnes PJ, Sturton G, Faro R, Harrington L, Perez-Vizcaino F, Moreno L, Mitchell JA   +6 more
doaj   +1 more source

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +1 more source

Effect of apamin on the responses to VIP, ATP and NANC neurone stimulation in the rat and cat gastric fundus

, 1991
1 The influence of apamin on non-adrenergic non-cholinergic (NANC) relaxation and on the effect of the putative transmitters VIP and ATP was examined in the rat and cat gastric fundus.
De Beurme, Freya A, Sas, Steven, Lefebvre, RomainGE338010003811850000-0003-2356-3714F3E60310-F0ED-11E1-A9DE-61C894A0A6B4, Lefebvre, Romain   +3 more
core   +1 more source

Distinct Host Gene Expression Patterns Induced by Covert Deformed Wing Virus Infections in Honeybees (Apis mellifera)

Archives of Insect Biochemistry and Physiology, Volume 121, Issue 4, April 2026.
A transcriptome study was established in Ordu, Türkiye using genetically related A. mellifera anatoliaca colonies founded by super‐sister queens. Nurse bees were collected and high‐quality RNA was sequenced on an Illumina NovaSeq 6000 platform, and analyzed on the Sabancı University HPC cluster (1).
Ali Sinan Kara, Samet Okuyan, Hatice Nur Kaynak, Serap Sakarya, Zeynep Ebrar Yavuz, Salim Aktürk, Gökhan Akdeniz, Aydin Turkec, Stuart J. Lucas   +8 more
wiley   +1 more source

Apamin-induced alterations in J774 1.6 macrophage metabolism [PDF]

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Among the immune system cells, macrophages have an important role. Apamin, a bee venom constituent, is important in the defense of these insects. Thus, we aimed to evaluate the metabolism of J774 1.6 macrophage cell line when exposed to isolated and ...
T. Picoli, C.M. Peter, M.G. Lopes, L.S. Barcelos, A.S. Varela Júnior, C.D. Corcini, M. Lima, S.O. Hübner, G.D.A. Vargas, G. Fischer   +9 more
doaj   +2 more sources

Pravastatin Corrects Endothelial Dysfunction in Ex Vivo Uterine Radial Arteries in Preeclampsia

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Aim Endothelium‐dependent relaxation in isolated uterine radial arteries from normotensive (NT) and preeclamptic (PE) pregnancies, and the acute effects of pravastatin in the latter vessels were assessed. Pravastatin is hypothesized to alleviate endothelial dysfunction in PE via modulating aspects of NO and endothelium‐derived ...
Nathan M. Luque, Leo Leader, Sandra M. Lowe, Steven D. Horrowitz, Marianne Tare, Victoria Hinkley, Vladimir V. Matchkov, Maged M. Costantine, Irit Markus, Lu Liu, Shaun L. Sandow, Timothy V. Murphy   +11 more
wiley   +1 more source

Health Effects of Bee Products: A Comprehensive Review

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Nutritional composition of bee products and some health effects. ABSTRACT Honey, bee pollen, propolis, bee bread, royal jelly, bee venom, beeswax, and apilarnil are among the bee‐derived products that may serve health‐related purposes, as they exhibit various biological activities such as antibacterial, antiviral, antifungal, antioxidant, anti ...
Nevin Sanlier, Elif Yildiz Kaya, Ikbal Irem Yucel   +2 more
wiley   +1 more source

Enhancing Selective Brain Cancer Therapy: Integrating Nanomedicine and Molecular Dynamics to Target the Cancerous Lipid Composition

Nano Select, Volume 7, Issue 2, February 2026.
Improving selectivity within therapeutic design is critical to ensure targeted delivery to brain tumors. Targeting the cellular membrane composition distinctive of the blood–brain barrier and brain cancer cells is explored in this review. Nanomedicine can be utilized for precise tumor recognition, and detailed mechanistic interactions of therapeutics ...
Mahnoor Kadri, Dominique de Jong‐Hoogland, Martin B. Ulmschneider   +2 more
wiley   +1 more source

Effect of apamin on I_SK2 in transfected HEK 293 cells.

, 2014
(A) The representative ISK2 tracings obtained by the descending voltage ramp protocol shown in the inset before (a) and after (b) apamin at time points indicated by arrows a and b in (B). (B) The time course of ISK2 at 0 mV.
Chih-Chieh Yu (127641), Peng-Sheng Chen (438895), Tomohiko Ai (438896), James N. Weiss (228015)   +3 more
core   +1 more source

Apamin as a BBB Shuttle and Its Effects on T Cell Population During the Experimental Autoimmune Encephalomyelitis-Induced Model of Multiple Sclerosis

, 2021
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system presented by autoimmune manifestations. This study aimed at investigating the effects of apamin administration on the activated T cell population in an experimental ...
Esmaeil, N., Fattahi, H., Aliomrani, M.
core   +1 more source