Results 71 to 80 of about 5,766 (207)
, 2013 (A) Cell-attached recording of a CIN in the presence of synaptic blockers picrotoxin (Pic, 100 µM), CNQX (10 µM) and DL-AP5 (AP5, 100 µM) showing changes in firing after application of rapamycin (dark gray) and apamin (black).
Billy C. Chieng (291650) +4 more
core +1 more source
Apamin-induced alterations in J774 1.6 macrophage metabolism [PDF]
Arquivo Brasileiro de Medicina Veterinária e ZootecniaAmong the immune system cells, macrophages have an important role. Apamin, a bee venom constituent, is important in the defense of these insects. Thus, we aimed to evaluate the metabolism of J774 1.6 macrophage cell line when exposed to isolated and ...
T. Picoli +9 more
doaj +2 more sources
Cardiovascular effects of apamin and BRL 34915 in rats and rabbits [PDF]
British Journal of Pharmacology, 1988 The cardiovascular effects of apamin, a selective blocker of certain calcium‐activated potassium channels, and BRL 34915, a vasodilator thought to act by opening of potassium channels, have been investigated in vivo in rats and rabbits. In anaesthetized normotensive rats, apamin (0.05 and 0.15 mg kg−1, i.v.) potentiated angiotensin II pressor ...
N S, Cook, R P, Hof
openaire +2 more sources
From Hive to Health: Anti‐Influenza Properties of Bee Products
International Journal of Microbiology, Volume 2026, Issue 1, 2026.Bee products have been long adapted as a natural remedy since centuries ago and studied for their bioactive properties including antimicrobial, anti‐inflammatory, antioxidant, and anticancer effects. Viral infections, including influenza, remain a significant global public health complication signifying the urgency for the development of alternative ...
Wei Wei Loo +3 more
wiley +1 more source
Mediators of Inflammation, Volume 2026, Issue 1, 2026.Background Rheumatoid arthritis (RA) is a long‐term inflammatory disease linked to higher mortality, joint degeneration, and long‐term disability. This study evaluated the anti‐inflammatory, antioxidant, and immunomodulatory effects of Capsicum annuum (CAP) hydroethanolic extract and bee venom (BV) in Freund’s complete adjuvant (FCA)‐induced RA in rats.
Ahmed Hussain +8 more
wiley +1 more source
The relationship between apamin binding and channel block in KCa2 potassium channels.
, 2013 Small conductance calcium-activated potassium channels (KCa2.1,2.2,2.3) are widely distributed throughout the body and are involved in diverse physiological processes including the regulation of neuronal firing and smooth muscle contraction.
Jenkinson, DH +3 more
core
The Concise Guide to PHARMACOLOGY 2025/26: Ion channels
British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +86 more
wiley +1 more source
The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines.
, 2000 The pharmacology of hSK1, a small conductance calcium-activated potassium channel, was studied in mammalian cell lines (HEK293 and COS-7). In these cell types, hSK1 forms an apamin-sensitive channel with an IC(50) for apamin of 8 nM in HEK293 cells and ...
Shah, M, Haylett, DG
core
Calcium regulation of muscle spindle mechanosensory afferent function
Experimental Physiology, Volume 110, Issue 10, Page 1457-1472, October 1, 2025.Abstract Extracellular calcium is crucial for the normal function of muscle spindle sensory afferents. They express multiple calcium buffering proteins. Extracellular calcium is essential for recycling of synaptic‐like vesicles (SLVs) in the terminals and for the stretch‐evoked inward calcium current of the receptor potential.
Anna Simon +5 more
wiley +1 more source
, 1999 In rat mesenteric artery, endothelium-derived hyperpolarizing factor (EDHF) is blocked by a combination of apamin and charybdotoxin (ChTX). The site of action of these toxins has not been established.
Frances Plane +2 more
core +1 more source