Results 21 to 30 of about 15,825 (230)
Breathing Life into Polycations [PDF]
, 2008 The lack of efficient delivery systems is still limiting the full therapeutic potential of siRNA. For the purpose of nucleic acid transfer, among other synthetic carrier systems, polycations have been applied.
Meyer, Martin +4 more
core +1 more source
Exploitation of proteomics strategies in protein structure-function studies [PDF]
, 2003 Mass spectrometry plays a central role in structural proteomics, particularly in highly intensive structural genomics projects. This review paper reports some examples taken from recent work from the authors' laboratory and is aimed at showing that modem
BIROLO, LEILA +3 more
core +1 more source
Helical Structure of Recombinant Melittin [PDF]
The Journal of Physical Chemistry B, 2018 Melittin is an extensively studied, 26-residue toxic peptide from honey bee venom. Because of its versatility in adopting a variety of secondary (helix or coil) and quaternary (monomer or tetramer) structures in various environments, melittin has been the focus of numerous investigations as a model peptide in protein folding studies as well as in ...
Lisa S. Ramirez +2 more
openaire +2 more sources
Conformational changes in melittin upon complexation with an anionic melittin analog
FEBS Letters, 1991 Melittin and its Glu‐(7,21,22,23,24) analog upon mixing in equimolar concentrations form a hybrid oligomer with significant helical structure, in conditions in which each peptide separately adopts a largely disordered structure. The hybrid exhibits both cold‐ and heat‐induced denaturations similar to the phenomena exhibited by proteins. The hybrid also
Ramalingam, Kalaiyarasi +2 more
openaire +2 more sources
Melittin‐induced fusion of acidic liposomes [PDF]
FEBS Letters, 1983 Melittin‐induced fusion of acidic liposomes. Fusion was observed in the electron‐microscope and assayed as intermixing of both liposomes' contents and membranes. The melittin concentrations required for fusion induction were in the μM range compared to over 10 mM Ca2+ required for a comparable effect.
Eytan, Gera D., Almary, Taiser
openaire +2 more sources
BMC Pharmacology and Toxicology, 2021 Background Melittin is one of the most studied antimicrobial peptides, and several in vitro experiments have demonstrated its antibacterial efficacy. However, there is evidence showing melittin has non-promising effects such as cytotoxicity and hemolysis.
Parvin Askari +3 more
doaj +1 more source
Protein flexibility is key to cisplatin crosslinking in calmodulin [PDF]
, 2012 Chemical crosslinking in combination with Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS) has significant potential for studying protein structures and proteinprotein interactions.
Jimenez-Roldan, J. Emilio +6 more
core +1 more source
Structural Dynamics, 2015 Trifluoroacetic acid (TFA) may be the cause of the bottleneck in high resolution structure determination for protein-peptide complexes. Fragment based drug design often involves the use of synthetic peptides which contain TFA (excipient). Our goal was to explore the effects of this excipient on a model complex: centrin-melittin-TFA.
Pastrana Rios, Belinda +2 more
openaire +4 more sources
Interdroplet bilayer arrays in millifluidic droplet traps from 3D-printed moulds [PDF]
, 2014 In droplet microfluidics, aqueous droplets are typically separated by an oil phase to ensure containment of molecules in individual droplets of nano-to-picoliter volume.
Abbyad +43 more
core +1 more source
Import of honeybee prepromelittin into the endoplasmic reticulum [PDF]
, 1987 Honeybee prepromelittin is correctly processed and imported by dog pancreas microsomes. Insertion of prepromelittin into microsomal membranes, as assayed by signal sequence removal, does not depend on signal recognition particle (SRP) and docking protein.
Müller, Günter, Zimmermann, Richard
core +5 more sources