Results 31 to 40 of about 15,825 (230)
Journal of Apicultural Science, 2015 Two enzyme-linked immunosorbent assay (ELISA) - based detection systems: indirect competitive ELISA and biotinylated double antibody sandwich ELISA (DAS-ELISA) were developed to determine the melittin concentration in honeybee (Apis mellifera) venom and ...
Suh Lindsey Y. K. +5 more
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Molecules, 2019 Malignant melanoma is the deadliest form of skin cancer and highly chemoresistant. Melittin, an amphiphilic peptide containing 26 amino acid residues, is the major active ingredient from bee venom (BV).
Haet Nim Lim +2 more
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Structural studies of bee melittin
Biophysical Journal, 1980 The question of how proteins refold in passing from an aqueous phase to an amphipathic environment such as a membrane is beig addressed by a structural study of bee melittin. Melittin is the toxic, main protein of bee venom, and has been shown by others to integrate into natural and synthetic membranes and to lyse a variety of cells.
Eisenberg, David +2 more
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Journal of Pharmacological Sciences, 2019 Melittin is a major peptide component of sweet bee venom that possesses anti-allergic, anti-inflammatory, anti-arthritis, anti-cancer, and neuroprotective properties. However, the therapeutic effects of melittin on muscle injury have not been elucidated.
Jae Eun Lee +4 more
doaj +1 more source
Development of a peptide-siRNA nanocomplex targeting NF- κB for efficient cartilage delivery [PDF]
, 2019 Delivery of therapeutic small interfering RNAs (siRNAs) in an effective dose to articular cartilage is very challenging as the cartilage dense extracellular matrix renders the chondrocytes inaccessible, even to intra-articular injections. Herein, we used
Akk, Antonina +7 more
core +3 more sources
Nucleic Acid Carriers Based on Precise Polymer Conjugates [PDF]
, 2011 Polymer polydispersity, random conjugation of functional groups, and poorly understood structure–activity relationships have constantly hampered progress in the development of nucleic acid carriers.
Troiber, Christina, Wagner, Ernst
core +1 more source
Molecules, 2016 Renal fibrosis is the principal pathological process underlying the progression of chronic kidney disease that leads to end-stage renal disease. Melittin is a major component of bee venom, and it has anti-bacterial, anti-viral, and anti-inflammatory ...
Hyun-Jin An +4 more
doaj +1 more source
Antioxidants, 2021 Melittin, a 26-amino acid peptide, is the main component of the venom of four honeybee species and exhibits neuroprotective actions. However, it is unclear how melittin ameliorates neuronal cells in oxidative stress and how it affects memory impairment ...
Cong Duc Nguyen, Gihyun Lee
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Nature of Melittin-Phospholipid Interaction
Biophysical Journal, 1982 Melittin, the major protein component of bee venom that possesses a strong hemolytic activity (1), is an amphipathic protein whose amino acid residues 1-20 are predominantly hydrophobic; residues 21-26 are hydrophilic. Determination of the molecular basis and specificity of the attractive forces involved in its interaction with membranes is essential ...
Georghiou, S. +2 more
openaire +2 more sources
The current landscape of the antimicrobial peptide melittin and its therapeutic potential
Frontiers in ImmunologyMelittin, a main component of bee venom, is a cationic amphiphilic peptide with a linear α-helix structure. It has been reported that melittin can exert pharmacological effects, such as antitumor, antiviral and anti-inflammatory effects in vitro and in ...
Hai-Qian Zhang +3 more
doaj +1 more source