Results 51 to 60 of about 15,825 (230)

A Perspective of Multi‐Reflecting TOF MS

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Time‐of‐flight mass spectrometry (TOF MS) excels in rapid and high‐sensitivity analysis, making it a cornerstone of analytical chemistry. But as sample complexity explodes in omics studies, so does the need for higher resolving power to ensure accurate results.
A. N. Verenchikov, V. V. Makarov, A. V. Vorobyev, S. N. Kirillov   +3 more
wiley   +1 more source

Antimicrobial and antibiofilm effects of melittin and apamin bee venoms from apis mellifera l. on eskape pathogens and cytotoxic effects on l929 fibroblast cells [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi
Public health is facing a worldwide challenge due to the emergence of multiple antibiotic resistance in ESKAPE (Enterococcus faecalis, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Escherichia coli ...
Elif AYDIN, Sema CETİNKAYA, Meliha KOLDEMİR GÜNDÜZ, Ayşe KOÇAK SEZGİN   +3 more
doaj   +1 more source

Impact of Honeybee Venom Melittin on Cell Viability of Different Prostate Cancer Lineages

Креативная хирургия и онкология, 2022
Background. Melittin is a major constituent of honeybee venom and comprises a water-soluble surfactant peptide with cytolytic effects potentially applicable in anticancer therapy.
R. R. Khalikov, D. D. Gromenko, S. Sh. Galimova, K. V. Danilko, I. D. Gromenko, Sh. N. Galimov, P. F. Litvitsky   +6 more
doaj   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, EarlyView.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

A biomimetic nanoparticle-enabled toxoid vaccine against melittin

International Journal of Nanomedicine, 2018
 Tianyi Kang,1 Chenyang Li,1,2 Ting Du,1 Yujiao Wu,1 Yuping Yang,1 Xuan Liu,1 Qianqian Zhang,1 Xiaoping Xu,3 Maling Gou1,4 1State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, People&rsquo ...
Kang T, Li C, Du T, Wu Y, Yang Y, Liu X, Zhang Q, Xu X, Gou M   +8 more
doaj  

Survey of probable synergism between melittin and ciprofloxacin, rifampicin, and chloramphenicol against multidrug-resistant Pseudomonas aeruginosa

Frontiers in Microbiology
BackgroundThe emergence of multidrug-resistant bacteria and also biofilm-associated infections is a great health concern due to the failure of available antibiotics. This has alerted scientists to developing alternative antibiotics.
Mahsa Sedaghati, Reza Akbari, Lida Lotfollahi Hagghi, Saber Yousefi, Tahere Mesbahi, Mahdieh Delfi   +5 more
doaj   +1 more source

Melittin as a safe compound to BALB/c mice immune system; a tiered approach immunotoxicity screening

BMC Complementary Medicine and Therapies, 2023
Background Maintenance of immune system integrity is a vital requirement to protect human body against pathogens/cancers. Natural compounds have long been used due to their benefits for the immune system. One of which is bee venom that contains a peptide
Gholamreza Karimi, Sina Fatemi, Bahram Memar, Mohammad-Bagher Khorrami, Arian Amali, Mahmood Sadeghi, Seyed-Alireza Esmaeili, Bamdad Riahi-Zanjani   +7 more
doaj   +1 more source

Effects of melittin on laying performance and intestinal barrier function of quails

Poultry Science, 2023
: To study the effects of melittin on egg-laying performance and intestinal barrier of quails, 240 quails (aged 70 d) were randomly divided into 4 groups with 6 replicates (10 quails per replicate). They were fed with basal diet (group B), basal diet + 0.
Zhili Li, Rongxu Liu, Xuehan Wang, Haigang Wu, Xianguo Yi, Li Huang, Qingming Qin   +6 more
doaj   +1 more source

Recent Advances in Bioconjugation of Aromatic Amino Acid Residues by a Reactivity‐Guided Approach

The Chemical Record, EarlyView.
This review highlights recent advances in the bioconjugation of aromatic amino acids residues, focusing on strategies that leverage their inherent chemical reactivity to enable precise and versatile modifications of biomacromolecules, illustrating relevant applications.
Bruno M. da S. Santos, Lívia C. R. M. da Frota, Thais G. Silva, Fernanda G. Finelli   +3 more
wiley   +1 more source

Melittin Tryptophan Substitution with a Fluorescent Amino Acid Reveals the Structural Basis of Selective Antitumor Effect and Subcellular Localization in Tumor Cells

Toxins, 2022
Melittin is a membrane-active peptide with strong anticancer activity against various cancers. Despite decades of research, the role of the singular Trp in the anticancer activity and selectivity of melittin remains poorly understood.
Yonghui Lv, Xu Chen, Zhidong Chen, Zhanjun Shang, Yongxiao Li, Wanting Xu, Yuan Mo, Xinpei Wang, Daiyun Xu, Shengbin Li, Zhe Wang, Meiying Wu, Junqing Wang   +12 more
doaj   +1 more source