Results 21 to 30 of about 25,852 (227)

Hyperthermic Intraperitoneal Chemotherapy with Melphalan: A Summary of Clinical and Pharmacological Data in 34 Patients

Gastroenterology Research and Practice, 2012
Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is a treatment option for peritoneal metastases. The optimal agents for HIPEC have not been established.
Lana Bijelic, Paul H. Sugarbaker, O. Anthony Stuart   +2 more
doaj   +1 more source

Diagnosis and the treatment of primary amyloidosis [PDF]

Vojnosanitetski Pregled, 2010
Backgraund. Primary amyloidosis belongs to a group of monoclonal plasma cell disorders, characterized by extracellular deposition of immunoglobulin light chain fibrils in various tissues and subsequent multiorgan dysfunction. Case report. We present a 51-
Đunić Irena, Tomin Dragica, Peruničić Maja, Vidović Ana, Čemerikić Vesna, Đurašinović Vladislava, Jaković Ljubomir, Janković Gradimir   +7 more
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Long-term outcomes of innovator versus generic melphalan formulation in autologous hematopoietic cell transplantation for multiple myeloma

Hematology/Oncology and Stem Cell Therapy, 2021
Background: Most data on autologous hematopoietic cell transplantation (auto-HCT) in myeloma are based on the use of innovator formulation of melphalan. Comparative bioequivalence and efficacy studies of generic melphalan are lacking.
Deepesh P. Lad, Pankaj Malhotra, Amol N. Patil, Ram V. Nampoothiri, Kripa Shanker Kasudhan, Alka Khadwal, Gaurav Prakash, Arihant Jain, Samir Malhotra, Neelam Varma, Savita Verma Attri, Subhash Varma   +11 more
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Melphalan as a Promising Treatment for BRCA-Related Ovarian Carcinoma [PDF]

, 2021
Introduction: Melphalan, as a bifunctional alkylating agent has been shown to be selectively efficient in BRCA-deficient case reports of epithelial ovarian cancer (EOC).
Rossi L., Virga A, Farolfi A., Bleve S., Conteduca V, Gianni C., Virga A., Gurioli G, Rossi L, Schepisi G, Brighi N., Burgio S. L., De Giorgi U., Menna C, Menna C., Lolli C., Brighi N, Lolli C, Farolfi A, Gianni C, Gurioli G., Altavilla A, Scarpi E., Bleve S, Conteduca V., Scarpi E, Schepisi G., Altavilla A., Burgio SL   +28 more
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Melphalan modifies the bone microenvironment by enhancing osteoclast formation [PDF]

, 2017
Melphalan is a cytotoxic chemotherapy used to treat patients with multiple myeloma (MM). Bone resorption by osteoclasts, by remodeling the bone surface, can reactivate dormant MM cells held in the endosteal niche to promote tumor development.
Rachael L. Terry, Quinn, JMW, Gillespie, M.T., Terry, Rachael L., McDonald, MM, Pettitt, JA, Gillespie, Matthew T., Pettitt, J.A., Shah, Shruti, Xu, J, Kovačić, Nataša, Down, J.M., Haffari, G., Xu, J., Haffari, Gholamreza, Michael J. Rogers, Jiake Xu, Rogers, M.J., Rogers, MJ, Peter I. Croucher, Rogers, Michael J., Kovačić, N, Quinn, Julian M W, Terry, RL, McDonald, M.M., Matthew T. Gillespie, McDonald, Michelle M., Shah, S, Croucher, Peter I., Price, John, Gillespie, MT, Down, JM, Croucher, PI, Jenny M. Down, Sindhu T. Mohanty, Nataša Kovačić, Chai, Ryan C., Down, Jenny M., Quinn, Julian M.W., Julian M.W. Quinn, Price, John T., Chai, RC, Chai, R.C., Mohanty, Sindhu T., Kovačić, N., Mohanty, S.T., Price, JT, Haffari, G, Ryan C. Chai, Shah, S., Jessica A. Pettitt, Michelle M. McDonald, John T. Price, Pettitt, Jessica A., Croucher, P.I., Quinn, J.M.W., Shruti Shah, Terry, R.L., Xu, Jiake, Mohanty, ST, Price, J.T., Gholamreza Haffari   +61 more
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Hepatic response after high-dose melphalan and stem cell transplantation in patients with AL amyloidosis associated liver disease

Haematologica, 2009
High-dose melphalan chemotherapy and autologous peripheral blood stem cell transplantation has been shown to result in durable hematologic response and prolonged overall survival in systemic AL amyloidosis.
Saulius Girnius, David C. Seldin, Martha Skinner, Kathleen T. Finn, Karen Quillen, Gheorghe Doros, Vaishali Sanchorawala   +6 more
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Repair of DNA interstrand crosslinks as a mechanism of clinical resistance to melphalan in multiple myeloma

, 2002
Melphalan is widely used as a preparative agent in patients with multiple myeloma (MM) undergoing autologous stem cell transplantation (SCT). Although disease relapse is the major cause of death after a melphalan-conditioned autograft, the mechanism ...
Mahendra, P, Hochhauser, D, Hockhauser, D, Spanswick, VJ, Shankaranarayana, P, Mahendra, Premini, Hughes, RG, Craddock, Charles; id_orcid, Craddock, C, Sekhar, M, Hartley, JA, Spanswick, V   +11 more
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Knockdown of Linc00515 Inhibits Multiple Myeloma Autophagy and Chemoresistance by Upregulating miR-140-5p and Downregulating ATG14

Cellular Physiology and Biochemistry, 2018
Background/Aims: The purpose of our experiments was to investigate the targeting relationship of linc00515, miR-140-5p and ATG14 and to explore the roles of linc00515, miR-140-5p and ATG14 in autophagy and chemoresistance of melphalan-resistant multiple ...
Daifeng Lu, Chuandong Yang, Zhitao Zhang, Yu Cong, Mochao Xiao   +4 more
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Isolated limb perfusion with melphalan activates interferon-stimulated genes to induce tumor regression in patients with melanoma in-transit metastasis

OncoImmunology, 2020
Hyperthermic isolated limb perfusion (ILP) with high-dose melphalan is a treatment option for melanoma patients with metastasis confined to limbs (in-transit metastasis). The therapy entails a complete response (CR) rate of 50–70%.
Junko Johansson, Roberta Kiffin, Ebru Aydin, Malin S. Nilsson, Kristoffer Hellstrand, Per Lindnér, Peter Naredi, Roger Olofsson Bagge, Anna Martner   +8 more
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The XPF-ERCC1 endonuclease and homologous recombination contribute to the repair of minor groove DNA interstrand crosslinks inmammalian cells produced by the pyrrolo[2,1-c][1,4]benzodiazepine dimer SJG-136

, 2005
SJG-136, a pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimer, is a highly efficient interstrand crosslinking agent that reacts with guanine bases in a 5'-GATC-3' sequence in the DNA minor groove.
Hartley, J.A., Ghadessy, Farid J, De Silva, I.U., Thurston, DE, Thurston, D.E., Clingen, PH, Ghadessy, FJ, Tilby, M.J., De Silva, IU, De Silva, Inusha U, Tilby, Michael J, Hartley, JA, McHugh, Peter J, Ghadessy, F.J., Clingen, Peter H, McHugh, P.J., Tilby, MJ, Hartley, John A, Thurston, David E, Clingen, P.H., McHugh, PJ   +20 more
core   +1 more source